Lipoxygenase inhibitory activity of crude bark extracts and isolated compounds from Commiphora berryi

Kumari, Ramesh; Arumugam, Meyyappan; Selvamani, P.; Mukherjee, Joydeep; Jaisankar, Parasuraman

doi:10.1016/j.jep.2011.09.007

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…Ten Commiphora species were evaluated for their anti-inflammatory activity using a 5-lipoxygenase (5-LOX) assay, and the stem extract of C. pyracanthoides was most active with IC 50 of 27.86 mg/ mL (Paraskeva et al, 2008). The petroleum ether bark extract of C. berryi and the purified friedelin showed soybean lipoxygenase inhibitory effects with IC 50 values of 15.3 mg/mL and 35.8 mM (Kumari et al, 2011b).…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

Shen

Wang

et al. 2012

Journal of Ethnopharmacology

203

161

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

Shen

Wang

et al. 2012

Journal of Ethnopharmacology

203

161

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“…Estimation of Beta-Carotene and Lycopene Contents of CMJE. Beta-carotene and lycopene contents of CMJE were estimated using a slightly modified method of that described by Kumari et al [14]. Briefly, 100 mg of the extract was mixed with 10 mL of the acetone-hexane mixture (4 : 6) for 1 minute and filtered.…”

Section: Gas Chromatography-mass Spectroscopy (Gc-ms)mentioning

confidence: 99%

The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes

Das

Al-Araby

et al. 2021

Oxidative Medicine and Cellular Longevity

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The purpose of this study was to look into the effects of green coconut mesocarp juice extract (CMJE) on diabetes-related problems in streptozotocin- (STZ-) induced type 2 diabetes, as well as the antioxidative functions of its natural compounds in regulating the associated genes and biochemical markers. CMJE’s antioxidative properties were evaluated by the standard antioxidant assays of 1,1-diphenyl-2-picrylhydrazyl (DPPH), superoxide radical, nitric oxide, and ferrous ions along with the total phenolic and flavonoids content. The α-amylase inhibitory effect was measured by an established method. The antidiabetic effect of CMJE was assayed by fructose-fed STZ-induced diabetic models in albino rats. The obtained results were verified by bioinformatics-based network pharmacological tools: STITCH, STRING, GSEA, and Cytoscape plugin cytoHubba bioinformatics tools. The results showed that GC-MS-characterized compounds from CMJE displayed a very promising antioxidative potential. In an animal model study, CMJE significantly ( P < 0.05 ) decreased blood glucose, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, uric acid, and lipid levels and increased glucose tolerance as well as glucose homeostasis (HOMA-IR and HOMA-b scores). The animal’s body weights and relative organ weights were found to be partially restored. Tissue architectures of the pancreas and the kidney were remarkably improved by low doses of CMJE. Compound-protein interactions showed that thymine, catechol, and 5-hydroxymethylfurfural of CMJE interacted with 84 target proteins. Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease. The data demonstrate the highly prospective use of CMJE in the regulation of tubulointerstitial tissues of patients with diabetic nephropathy.

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“…Oliveira-Junior et al very recently demonstrated that lupeol ( 18 ) (0.1 μM) exhibited anti-neuroinflammatory and neuroprotective activity in cerebellar cells [97]. Friedelin ( 19 ) can also possibly contribute to anti-inflammatory action [98], as shown by its lipoxygenase inhibitory activity [99] and several in vivo assays on mice [100]. On the other hand, cyclooxygenase was inhibited only slightly and lipoxygenase not at all in another study [101], and no inhibition of the platelet-activating factor (PAF)-stimulated release of β-glucuronidase from polymorphonuclear leukocytes was observed [102].…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Maytenus macrocarpa (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity

et al. 2019

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Maytenus macrocarpa (Celastraceae) is a tree native to Amazonia. Its roots, leaves, bark, and combinations of these are used in traditional medicine mainly to treat rheumatism and, to a lesser extent, to heal wounds and to combat bronchitis and diarrhea. To date, mainly triterpenes and dihydro-β-agarofuran sesquiterpenes were isolated from M. macrocarpa. Extracts and selected pure compounds isolated from the leaves, roots, and stem bark showed antibacterial, antiviral, antiparasitic, anti-inflammatory, and cytotoxic activities in vitro. The aim of this review is to summarize the available ethnobotanical, phytochemical, and pharmacological information about this traditional Amazonian medicinal tree, as well as to attract the attention of phytochemists and pharmacognosists to this potentially interesting source of ethnopharmaceuticals.

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Lipoxygenase inhibitory activity of crude bark extracts and isolated compounds from Commiphora berryi

Cited by 11 publications

References 22 publications

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes

Maytenus macrocarpa (Ruiz & Pav.) Briq.: Phytochemistry and Pharmacological Activity

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