Anti-inflammatory activity of clove (
            <i>Eugenia caryophyllata</i>
            ) essential oil in human dermal fibroblasts

Han, Xuesheng; Parker, Tory L.

doi:10.1080/13880209.2017.1314513

Cited by 139 publications

(87 citation statements)

References 15 publications

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“…Han and Parker [37] have revealed the antiviral, antimicrobial, antifungal, anticancer, antioxidant, and anti-inflammatory activities of the CEO and its main active constituent eugenol, and they revealed that CEO influenced the cancer biology and cell cycle control. The problems of pathogen resistance, as well as the toxic residues to most of the commercially available antimicrobial drugs severely weaken their effective curative and protective approaches [37][38][39]. Therefore, it is clear that the development of new and effective antimicrobial treatment options is vital for improving disease treatment and control.…”

Section: Biological/biochemical Properties Of S Aromaticummentioning

confidence: 99%

“…Pharmacologically, clove oil is used in a wide range as an antiseptic in oral diseases and for the treatment of toothaches, allergy disorders, asthma, acne, scars, and rheumatoid arthritis, and it showed antispasmodic and acaricidal effects toward Dermatophagoides pteronyssinus and Dermatophagoides farina [43,44]. Moreover, the CEO has shown aphrodisiac, antipyretic, appetizer, hypnotic, anxiolytic, antiemetic, analgesic, decongestant, antimicrobial, antiepileptic, myorelaxant, anti-inflammatory, and expectorant properties as well as has a medicinal influence against trophic disorder [37,45]. Notably, tannins, ellagic acid, gallic acid, flavonoids and their glycosides isolated from alcoholic and aqueous clove buds extracts were reported to have antithrombotic, antiprotozoal, hypoglycemic, anti-inflammatory, gastroprotective, and aphrodisiac efficacy [46][47][48][49][50].…”

Section: Biological/biochemical Properties Of S Aromaticummentioning

confidence: 99%

“…Clove exerted anti-inflammatory and immunomodulatory activities by suppressing the lipopolysaccharide (LPS) action as well as the nuclear factor-κB (NF-κB) pathway. Han and Parker [37] reported that the anti-inflammatory activity of clove may be related to the active compound, eugenol.…”

Section: Efficacy In Diseasesmentioning

confidence: 99%

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Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities

et al. 2020

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Herbal medicinal products have been documented as a significant source for discovering new pharmaceutical molecules that have been used to treat serious diseases. Many plant species have been reported to have pharmacological activities attributable to their phytoconstituents such are glycosides, saponins, flavonoids, steroids, tannins, alkaloids, terpenes, etc. Syzygium aromaticum (clove) is a traditional spice that has been used for food preservation and possesses various pharmacological activities. S. aromaticum is rich in many phytochemicals as follows: sesquiterpenes, monoterpenes, hydrocarbon, and phenolic compounds. Eugenyl acetate, eugenol, and β-caryophyllene are the most significant phytochemicals in clove oil. Pharmacologically, S. aromaticum has been examined toward various pathogenic parasites and microorganisms, including pathogenic bacteria, Plasmodium, Babesia, Theileria parasites, Herpes simplex, and hepatitis C viruses. Several reports documented the analgesic, antioxidant, anticancer, antiseptic, anti-depressant, antispasmodic, anti-inflammatory, antiviral, antifungal, and antibacterial activity of eugenol against several pathogenic bacteria including methicillin-resistant Staphylococcus epidermidis and S. aureus. Moreover, eugenol was found to protect against CCl4−induced hepatotoxicity and showed a potential lethal efficacy against the multiplication of various parasites including Giardia lamblia, Fasciola gigantica, Haemonchus contortus, and Schistosoma mansoni. This review examines the phytochemical composition and biological activities of clove extracts along with clove essential oil and the main active compound, eugenol, and implicates new findings from gas chromatography-mass spectroscopy (GC-MS) analysis.

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Section: Biological/biochemical Properties Of S Aromaticummentioning

confidence: 99%

Section: Biological/biochemical Properties Of S Aromaticummentioning

confidence: 99%

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Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities

et al. 2020

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show abstract

“…Clove, a spice obtained from the dried flower of the tree Syzygium aromaticum L., has been used in traditional medicine for centuries as an antiseptic, analgesic, or in dental care [1]. Nowadays, several studies document a broad range of biological effects of clove including antibacterial [2,3], antifungal [4], antimutagenic [5], antihistaminic [6], antiinflammatory [7], or antioxidant [8]. Moreover, the antiproliferative activity of clove essential oil or eugenol, its main component, has also been described [9,10].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells

et al. 2020

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In recent decades, several spices have been studied for their potential in the prevention and treatment of cancer. It is documented that spices have antioxidant, anti-inflammatory, immunomodulatory, and anticancer effects. The main mechanisms of spices action included apoptosis induction, proliferation, migration and invasion of tumour inhibition, and sensitization of tumours to radiotherapy and chemotherapy. In this study, the ability of clove buds extract (CBE) to induce oxidative stress, DNA damage, and stress/survival/apoptotic pathways modulation were analysed in MCF-7 cells. We demonstrated that CBE treatment induced intrinsic caspase-dependent cell death associated with increased oxidative stress mediated by oxygen and nitrogen radicals. We showed also the CBE-mediated release of mitochondrial pro-apoptotic factors, signalling of oxidative stress-mediated DNA damage with modulation of cell antioxidant SOD (superoxide dismutase) system, and modulation activity of the Akt, p38 MAPK, JNK and Erk 1/2 pathways.

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“…The individual essential oils in the EOB that we have studied previously include frankincense and clove oils (Han & Parker, 2017c, 2017d. It was interesting to observe that certain biomarker effects from the individual essential oils were conserved in the blend, while others were lost.…”

Section: Bioactivity Profile Of Eob In Hdf3cgf Systemmentioning

confidence: 96%

Biological Activity of an Essential Oil Blend in Human Dermal Fibroblasts

2019

ARJDG

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Research on the biological activities of essential oilsin human skin cells is limited. This study first analyzed the effect of an essential oil blend (EOB) on 17 important protein biomarkers in cytokine-stimulated human dermal fibroblasts. The EOB was composed of essential oils of frankincense resin, sweet orange peel, litsea fruit, thyme plant, clove bud, summer savory plant, and niaouli leaf. The results showed that EOB had excellent antiproliferative activity. It significantly increased vascular cell adhesion molecule 1 levels and slightly increased the monocyte chemoattractant protein 1 and epidermal growth factor receptor production. We then studied the effect of the EOB on the expression levels of 21,224 genes in the same cells. We found that the EOB markedly affected genome-wide gene expression. Further analysis revealed that the EOB pleiotropically regulated multiple signaling pathways in human cells including hepatic fibrosis activation, antigen presentation, mitotic roles of the polo-like kinase, and cyclin and cell cycle regulation. Many pathways significantly affected by the EOB are closely related to inflammatory and immune responses. The results suggest that the EOB may affect biological processes and global gene expression in human skin cells. Further research into the underlying mechanism of action of the EOB is needed.

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Anti-inflammatory activity of clove ( Eugenia caryophyllata ) essential oil in human dermal fibroblasts

Cited by 139 publications

References 15 publications

Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities

Syzygium aromaticum L. (Myrtaceae): Traditional Uses, Bioactive Chemical Constituents, Pharmacological and Toxicological Activities

Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells

Biological Activity of an Essential Oil Blend in Human Dermal Fibroblasts

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