Anti-inflammatory activity of Chinese medicinal vine plants

Li, Rachel; Lin, G. David; Myers, Stephen P; Leach, D. L.

doi:10.1016/s0378-8741(02)00339-2

Cited by 172 publications

(109 citation statements)

References 13 publications

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“…Obtained results were comparable with the inhibitory effect of the PLA2 activity by various extracts from Aloe vera L. (Aloeaceae), which possess an interesting anti-inflammatory potential (Habeeb et al 2007;Kammoun et al 2011). Li et al (2003) studied the effect of ethanol extracts from various plants, used in traditional Chinese medicine to treat inflammatory conditions, against a panel of key enzymes related to inflammation process such as phospholipase A2, cyclooxygenases and lipoxygenases. In fact, all the plant extracts showed inhibitory activities against at least one of these enzymes.…”

Section: Inhibition Of Phospholipase A2 Activitymentioning

confidence: 62%

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous:Diplotaxis simplex

Jdir

Khemakham

Najjaa

et al. 2016

Pharmaceutical Biology

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Context The present study deals with new biological properties of the wild edible Diplotaxis simplex (Viv.) Spreng (Brassicaceae). Objectives The current study evaluates the antioxidant, the anti-inflammatory and the anti-cancer properties of ethyl acetate and ethanol extracts from D. simplex flowers. Materials and methods The anti-proliferative activity of the extracts (10-70 mg/mL) was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) against human colon cancer cell line Caco-2. The anti-inflammatory potential was evaluated by the inhibitory effect of the extracts (1.5-7.5 mg/mL) on phospholipase A2 activity as well as on carrageenan-induced paw oedema in mice. Extracts (200 mg/kg) or indomethacin (50 mg/kg) as positive control were injected intraperitoneally for albino mice prior to the induction of the oedema by carrageenan. Antioxidant activities were investigated using various complementary methods.Results Flower extracts contained a high level of polyphenolics (17.10-52.70 mg GAE/g) and flavonoids (74.20-100.60 mg QE/g), which correlate with its appreciable antioxidant potential in b-carotene peroxidation (IC 50 value: 12.50-27.10 mg/mL), DPPH radical-scavenging (IC 50 value: 0.20-0.40 mg/mL), Fe 3+ reducing (EC 50 value: 0.10-0.14 mg/mL) and Fe 2+ chelating (IC 50 value: 0.20-0.60 mg/mL) assays. These extracts were effective in inhibiting cancer cell growth (IC 50 value: 62.0-63.25 mg/mL). Besides, the ethyl acetate extract inhibited phospholipase A2 activity (IC 50 value: 2.97 mg/mL) and reduced the paw oedema in mice (from 0.38 ± 0.01 to 0.24 ± 0.01 cm), 4 h postcarrageenan challenge. Conclusion These data suggest that D. simplex may be useful as a candidate in the treatment of inflammation and the colon cancer.ARTICLE HISTORY

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Section: Inhibition Of Phospholipase A2 Activitymentioning

confidence: 62%

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous:Diplotaxis simplex

Jdir

Khemakham

Najjaa

et al. 2016

Pharmaceutical Biology

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“…This, or differences in the methods used to prepare the plant extracts, could also account for the inconsistent results reported concerning inhibition of COX-1 and COX-2 activity. In one study, an extract did not inhibit the activity of either enzyme (Maekawa et al, 1999); in another, an extract inhibited activity of COX-1 more strongly than that of COX-2 (Li et al, 2003a).…”

Section: Proinflammatory Enzymes-nitric Oxide Synthase (Nos) Catalyzementioning

confidence: 91%

“…Suppression of prostaglandin E 2 (PGE 2 ) synthesis was observed (Chang et al, 1997;Tao et al, 1998;Maekawa et al, 1999), but the mechanism of the suppression was not determined. Inhibition of lipoxygenase was also noted (Li et al, 2003a). However, in some studies the effects varied depending on the cell line used .…”

Section: Proinflammatory Enzymes-nitric Oxide Synthase (Nos) Catalyzementioning

confidence: 99%

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

et al. 2007

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Plants in the genus Tripterygium, such as Tripterygium wilfordii Hook. f., have a long history of use in traditional Chinese medicine. In recent years there has been considerable interest in the use of Tripterygium extracts and of the main bioactive constituent, the diterpene triepoxide triptolide (1), to treat a variety of autoimmune and inflammation-related conditions. The main mode of action of the Tripterygium extracts and triptolide (1) is the inhibition of expression of proinflammatory genes such as those for interleukin-2 (IL-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-2) and interferon-gamma (IFN-γ). The efficacy and safety of certain types of Tripterygium extracts were confirmed in human clinical trials in the US and abroad. Over 300 compounds have been identified in the genus Tripterygium, and many of these have been evaluated for biological activity. The overall activity of the extract is based on the interaction between its components. Therefore, the safety and efficacy of the extract cannot be fully mimicked by any individual constituent. This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components.

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“…This study was able to justify the potential effect and social value in the use of vines in the management of inflammatory conditions. These similar effects are potential in the management of rheumatoid Arthritis's [55].…”

Section: Herbal Remedies With Potential Anti-arthritic Activitiesmentioning

confidence: 77%

Evidence Based Targeting of Cytokines for Conventional and the Potential Phytotherapies in Management of Rheumatoid Arthritis

Mutua¹,

Kk²,

Mr³

et al. 2017

J Arthritis

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Rheumatoid arthritis is an autoimmune disease that leads to chronic, systemic inflammatory reaction that primarily affects synovial joints. Current cytokine based therapies are effective and safe. However, they have a challenge of having short plasma half-life and even higher doses are required to manage the conditions. The processes involved in production using phage and viral technologies are expensive. Herbal medicines have been used for long and are considered safe and effective as medicines for many inflammatory related diseases. Many plants also posit as a potent anti-inflammatory agents. Evidence for use of herbal plants in both human and animal trials in studies suggest significant potential of application in herbal formulation in management of rheumatoid arthritis. Specifically, many studies suggest the direct effect of managing the agents of inflammation as a way of managing rheumatoid arthritis. Most evidence links the involvement of pro-inflammatory cytokines (interleukin-1, TNF-α, IFN-α, and NF-кB) to the long term. It has also been suggested that the use of protective cytokines such as (Interleukin-4, Interleukin-6, Interleukin-8). Key pathways involve cyclooxygenase 1 and 2, 5-Lipooxygenase, formations of metalloproteinases, and inhibition of formation of prostaglandin E2. Use of herbal medicines has potential of improving joint conditions in rheumatoid arthritis. Use of herbal extracts offers better, cheap and affordable solution for long term management of rheumatoid arthritis in patients. They also show potential of offering multifunctional approaches to the management of the conditions through their anti-oxidative and anti-inflammatory mechanisms. Further studies are required to demonstrate the mechanisms involved in activation of protective cytokines in the management of rheumatoid arthritis.

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Anti-inflammatory activity of Chinese medicinal vine plants

Cited by 172 publications

References 13 publications

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous:Diplotaxis simplex

Anti-inflammatory and anti-proliferative activities of the wild edible cruciferous:Diplotaxis simplex

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)

Evidence Based Targeting of Cytokines for Conventional and the Potential Phytotherapies in Management of Rheumatoid Arthritis

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