Anti-inflammatory activity of a new triterpenoid saponin from <i>carthamus tinctorius</i> linn

Yadava, R. N.; Chakravarti, Nitin

doi:10.1080/14756360701715422

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…Saponins are phytochemicals and natural glycosides with a wide range of pharmacological properties. The bioactive triterpenoid saponin, 3β- O -[β- d -xylopyranosyl(1→3)- O -β- d -galactopyra-nosyl]-lup-12-ene-28 oic acid-28- O -α- l -rhamnopyranosyl ester compound in methanolic fraction, was reported in roots of C. tinctorius [ 43 ]. Furthermore, recent studies reported two alkaloid–saponins compounds ( N -coumaroylserotonin and N -feruloylserotonin) in C. tinctorius seeds [ 20 ].…”

Section: Safflower Chemical Compositionmentioning

confidence: 99%

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A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

et al. 2020

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Safflower (Carthamus tinctorius L.) has long been grown as a crop due to its commercial utility as oil, animal feed, and pharmacologically significant secondary metabolites. The integration of omics approaches, including genomics, transcriptomics, metabolomics, and proteomics datasets, has provided more comprehensive knowledge of the chemical composition of crop plants for multiple applications. Knowledge of a metabolome of plant is crucial to optimize the evolution of crop traits, improve crop yields and quality, and ensure nutritional and health factors that provide the opportunity to produce functional food or feedstuffs. Safflower contains numerous chemical components that possess many pharmacological activities including central nervous, cardiac, vascular, anticoagulant, reproductive, gastrointestinal, antioxidant, hypolipidemic, and metabolic activities, providing many other human health benefits. In addition to classical metabolite studies, this review focuses on several metabolite-based working techniques and updates to provide a summary of the current medical applications of safflower.

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Section: Safflower Chemical Compositionmentioning

confidence: 99%

“…-[β-d-xylopyranosyl(1→3)-O-β-d-galactopyra-nosyl]-lup-12-ene-28 oicacid-28-O-α-lrhamnopyranosyl ester compound in methanolic fraction, was reported in roots of C. tinctorius[43]. Furthermore, recent studies reported two alkaloid-saponins compounds (N-coumaroylserotonin and N-feruloylserotonin) in C. tinctorius seeds[20].…”

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confidence: 98%

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

et al. 2020

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“…324 Lupane saponins with known genins include stallatoside B and erucasaponin A from the cactus Stenocereus eruca 325 and a saponin from roots of Carthamus tinctorius. 326 Gouanic acids A 697 and B 698 from aerial parts of Gouania ulmifolia 327 and 1-epi-ceanothic acid 699 from Gleditsia sinensis 328 are 3(2/1)-abeo-lupane derivatives. Elephanmollen 700 is a D:C-friedolupane derivative from Elephantopus mollis that shows cytotoxic properties.…”

Section: Tetranortriterpenoidsmentioning

confidence: 99%

Triterpenoids

Connolly

Hill

2010

Nat. Prod. Rep.

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“…Saponins are known to have interesting activities, e.g., as anti-inflammatory and diuretic agents [1][2][3][4][5]. In addition, saponins inhibit the growth of certain types of tumors in animals, particularly lung and blood cancers, without killing normal cells [6,7].…”

Section: Introductionmentioning

confidence: 99%

Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines

Kim

Hong

2010

Apoptosis

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In this study, we investigated the signaling pathways implicated in SSa-induced apoptosis of human colon carcinoma (HCC) cell lines. SSa-induced apoptosis of HCC cells was associated with proteolytic activation of caspase-9, caspase-3, and PARP cleavages and decreased levels of IAP family members, such as XIAP and c-IAP-2, but not of survivin. The fluorescence intensity of DiOC6 was significantly reduced after SSa treatment. CsA significantly inhibited SSa-induced loss of mitochondrial transmembrane potential and moderately inhibited SSa-induced cell death. SSa treatment also enhanced the activities of caspase-2 and caspase-8, Bid cleavage, and the conformational activation of Bax. Additionally, SSa-induced apoptosis was inhibited by both the selective caspase-2 inhibitor z-VDVAD-fmk and the selective caspase-8 inhibitor z-IETD-fmk and also by si-RNAs against caspase-2 and caspase-8. The selective caspase-9 inhibitor, z-LEHD-fmk, also inhibited SSa-induced apoptosis, albeit to a lesser extent compared to z-VDVAD-fmk and z-IETD-fmk, indicating that both mitochondria-dependent and mitochondria-independent pathways are associated with SSa-induced apoptosis. Both z-VDVAD-fmk and z-IETD-fmk significantly attenuated the colony-inhibiting effect of SSa. Moreover, inhibition of caspase-2 activation by the pharmacological inhibitor z-VDVAD-fmk, or by knockdown of protein levels using a si-RNA, suppressed SSa-induced caspase-8 activation, Bid cleavage, and the conformational activation of Bax. Although caspase-8 is an initiator caspase like caspase-2, the inhibition of caspase-8 activation by knockdown using a si-RNA did not suppress SSa-induced caspase-2 activation. Altogether, our results suggest that sequential activation of caspase-2 and caspase-8 is a critical step in SSa-induced apoptosis.

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Anti-inflammatory activity of a new triterpenoid saponin from carthamus tinctorius linn

Abstract: , was isolated from the methanolic fraction of the roots of this plant by various colour reactions, chemical degradations and spectral analysis. Compound (A) showed anti-inflammatory activity.

Cited by 9 publications

References 16 publications

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

A Metabolic Perspective and Opportunities in Pharmacologically Important Safflower

Triterpenoids

Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinoma cell lines

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