Anti-inflammatory activity and QSAR studies of compounds isolated from Hyacinthaceae species and Tachiadenus longiflorus Griseb. (Gentianaceae)

Toit, Karen du; Elgorashi, E.E.; Malan, Sarel F.; Drewes, Siegfried E.; Staden, J. Van; Crouch, Neil R.; Mulholland, Dulcie A.

doi:10.1016/j.bmc.2005.01.036

Cited by 40 publications

(24 citation statements)

References 18 publications

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“…Inflammation is a complex process and many different mediators are involved including enzymes (cyclooxygenase, nitric oxide synthase, and protease) and their intermediate products and end products. Cyclooxygenase enzymes (COX-1/COX-2) convert arachidonic acid to the unstable prostaglandin intermediates PGG 2 and PGH 2 , which involve in inflammation [35] . Nitric oxide (NO) a toxic gas has been related with various diseases such as atherosclerosis, inflammation and carcinogenesis.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Nirmal

Rajput

Prasad³

et al. 2015

Asian Pacific Journal of Tropical Medicine

227

153

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Caesalpinia sappan L. (CS) is a plant of Leguminosae family, commonly known as Brazil or Sappan wood. CS is distributed in Southeast Asia and its dried heartwood has been used as traditional ingredient of food or beverages and has a wide variety of medicinal properties. Higher extraction yield of CS wood was achieved with 95% ethanol for 2 h. Chemical constituent's investigation of sappan wood resulted in the isolation of various structural types of phenolic components including one xanthone, one coumarin, three chalcones, two flavones three homoisoflavonoids and brazilin. Brazilin [(6a S-cis)-7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)- tetrol], a major and active compound found in CS heartwood. Most of the folkloric uses of brazilin were validated by the scientific studies such as antioxidant, antibacterial, anti-inflammatory, anti-photoaging, hypoglycemic, vasorelaxant, hepatoprotective and anti-acne activity. CS heartwood extract is safe and did not produce any acute or subacute toxicity in both male and female rats. Brazilin is the safe natural compound having potential to develop as a medicinal compound with application in food, beverage, cosmetics and pharmaceutical industries to screen its clinical use in modern medicine. The information gained could provide the important and potential approach for pharmaceutical researcher to implicate the knowledge of brazilin in the formulation of new drug and to reveal therapeutic and gaps requiring future research opportunities. More studies are needed to evaluate the potential application of brazilin as preservative and coloring agent in food processing industries.

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Nirmal

Rajput

Prasad³

et al. 2015

Asian Pacific Journal of Tropical Medicine

227

153

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“…The experiments were performed using an assay originally described by Noreen et al (1998), with some modification by Du Toit et al (2005). For the COX-1 assay, commercial COX-1 (from ram seminal vesicles, Sigma-Aldrich) (10 ml/sample) enzymes and haematin (co-factor) (50 ml/sample) were pre-incubated for 5 min on ice.…”

Section: Ferric Reducing Antioxidant Power (Frap)mentioning

confidence: 99%

The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhoea

Ahmed

Elgorashi

Moodley

et al. 2012

Journal of Ethnopharmacology

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“…Antimony (III) chloride (SbCl3) reagent was used to identify cardiac glycosides, speci�cally the bufadienolide type with a high probability of Proscillaridin A to be present in M. natalensis bulbs [103]. Most of the Hyacinthaceae species also contain homoiso�avanones, which possess antibacterial activity [108,109]. Homoiso�avanones were also detected in M. natalensis by Crouch et al [110], and this is one of the components that are responsible for the antiin�ammatory properties [103].…”

Section: Phytochemistry and Biological Activitymentioning

confidence: 99%

Commercially Important Medicinal Plants of South Africa: A Review

Street

Prinsloo

2012

Journal of Chemistry

137

114

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ere is a growing interest in natural plant-based remedies as a source for commercial products. Around 80% of the South African population use traditional medicines to meet their primary health care needs; however, only a few South African medicinal plants have been exploited to their full potential in terms of commercialization. e opportunity for bioprospecting of plant compounds for novel pharmaceuticals remains largely untapped. Certain renowned medicinal plants of international acclaim including buchu and rooibos are currently contributing to local enterprise; however, other exciting opportunities exist for commonly used plants which have not yet reached the international arena. is paper focuses on the key research and development contributions of 10 commercially important medicinal plants of South Africa. �raditional uses, scienti�c validation, commercialisation developments, as well as both potential opportunities and setbacks are discussed.

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Anti-inflammatory activity and QSAR studies of compounds isolated from Hyacinthaceae species and Tachiadenus longiflorus Griseb. (Gentianaceae)

Cited by 40 publications

References 18 publications

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review

The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhoea

Commercially Important Medicinal Plants of South Africa: A Review

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