The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhoea

Ahmed, Aroke Shahid; Elgorashi, E.E.; Moodley, Nivan; McGaw, Lyndy Joy; Naidoo, Vinny; Eloff, Jacobus Nicolaas

doi:10.1016/j.jep.2012.08.004

Cited by 78 publications

(54 citation statements)

References 52 publications

(52 reference statements)

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“…Two Gram positive strains of Bacillus subtilis (ATCC 6633), Staphylococcus aureus (ATCC 29737) and two Gram negative bacterial strains of Escheria coli (ATCC 10536) and Pseudomonas aeruginosa (ATCC 9027) were chosen. The MIC was carried out by serial broth microdilution with slight modification (Kaikabo and Eloff, 2011;Ahmed et al, 2012;Perumal et al, 2012;Sarikurkcu et al, 2015;Sufian et al, 2013). The sample stock solution (1000 µg/mL) was prepared in 5% DMSO in nutrient broth (NB) supplemented with 0.02% (v/v) Tween 80.…”

Section: Antibacterial Assaymentioning

confidence: 99%

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

et al. 2016

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Calophyllum symingtonianum is a rare species from the Calophyllum genus that belongs to the Guttiferae family. Calophyllum has been recognized as a potential medicinal plant due to its many bioactive phytochemicals especially coumarins and chromanone acids. In this study, the cytotoxic activities against MCF-7 and A-549 and antibacterial activities towards S. aureus, B. subtilis, P. aeruginosa and E. Coli of three coumarins known as inophyllum D, inophyllum H and calanone as well as chromanone acid identified as isocordato-oblongic acid isolated from this plant were evaluated. Inophyllum H exhibited the highest IC50 values against MCF-7 at 25.56 µg/mL and A-549 at 26.41µg/mL. Isocordato-oblongic acid showed moderate antibacterial activity against S. aureus and B. subtilis at 125µg/mL and 62.5µg/mL, respectively. This study suggests C. symingtonianum as a potential plant for cytotoxic and antibacterial phytochemicals.

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Section: Antibacterial Assaymentioning

confidence: 99%

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

et al. 2016

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“…A study by Luseba et al (2007) identified the anti-inflammatory (cyclo-oxygenase-1 and -2 inhibition) effects of some of the South African medicinal plants used to treat skin diseases such as; C. quadrangularis, R. communis and Ziziphus mucronata. A study by Ahmed et al (2012) also identified the anti-inflammatory effects of four South African Bauhinia species, where the ability of Bauhinia petersiana to inhibit COX-1 and COX-2 was identified. Marnewick et al (2005) identified the anti-oxidant, anti-inflammatory and antitumour properties of Aspalathus linearis and the respective chemical compounds.…”

Section: Anti-inflammatory Effects Of Medicinal Plants Used To Treat mentioning

confidence: 99%

Southern African medicinal plants used to treat skin diseases

Mabona

Vuuren

2013

South African Journal of Botany

116

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a b s t r a c tThis overview of southern African medicinal plants of dermatological relevance explores the fundamental knowledge available on the antimicrobial, anti-inflammatory, and wound healing properties of medicinal plants used to treat skin ailments. Also included is an overview undertaken on the phytochemistry and toxicity of plants used in treatments related to diseases of the skin. Some findings include the predominance of leaf material used (48%), as well as the frequent use of decoctions (35%). Dermatological skin pathogens such as Propionibacterium acnes, Microsporum canis, Trichophyton mentagrophytes and Epidermophyton floccosum are recommended for study in future antimicrobial research. Attention to these aspects should lead to new directives for commercialization and provide insight towards the understanding of some neglected plant species used for the treatment of skin diseases.

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“…The toxicity of medicinal plants depends on many factors such as the part of plant and the extraction solvent used, which will determine the composition and biological activity of the extracts as well as the bioavailability of their components. Moreover, poor handling of raw or processed materials may produce exogenous toxic contaminants, not inherent as plant phytochemicals (9).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

et al. 2016

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The antimicrobial, antioxidative, anti-inflammatory activity and cytotoxicity of different fractions of four South African Bauhinia species used traditionally to treat diarrhoea

Cited by 78 publications

References 52 publications

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

Cytotoxic and Antibacterial Evaluation of Coumarins and Chromanone Acid from Calophyllum symingtonianum

Southern African medicinal plants used to treat skin diseases

Hepatoprotective and antidiabetic activities of Fraxinus angustifolia Vahl extracts in animal models: characterization by high performance liquid chromatography analysis

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