Anti-inflammatory actions of a taurine analogue, ethane β-sultam, in phagocytic cells, in vivo and in vitro

Abstract

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Ethane-β-Sultam Modifies the Activation of the Innate Immune System Induced by Intermittent Ethanol Administration in Female Adolescent Rats

“…In our recent studies [25], we clearly showed that the anti-inflammatory property of taurine was mediated via stabilisation of IkaBa, thus preventing activation of NFkappaB. Although taurine can be synthesised intracellularly from cysteine and methionine, the diet is the main source for human nutrition.…”

“…Although taurine can be synthesised intracellularly from cysteine and methionine, the diet is the main source for human nutrition. Taurine uptake from the plasma is tightly controlled by the taurine transporter, TauT, such that supplementation with taurine will only transiently increase taurine levels within the liver and to a lesser extent in the brain [25].…”

“…Since we had shown the anti-inflammatory action of ethane-β-sultam in vitro in macrophages and microglia in our earlier cell culture studies [25], it was of interest to ascertain whether it would have an anti-inflammatory action in an animal model of binge drinking. In addition, since β-lactams antibiotics alter glutamate transporter 1, it was of interest to ascertain whether extracellular glutamate content might be influenced by ethane-β-sultam.…”

Synthesis, conformation and antiproliferative activity of isothiazoloisoxazole 1,1-dioxides

“…The field is dominated by the β-lactams (1) [ Figure 1] due to the importance that they have acquired as anti-infective agents. [1][2][3] The corresponding β-sultams (2) are also known and have attracted attention as taurine precursors, 4,5 β-lactamase inhibitors, 6 D,D-peptidase inhibitors, 7 human neutrophil elastase inhibitors, [8][9][10] azoreductase inhibitors, 11 anti-inflammatory agents, 12 potential treatments for alcohol dependency, 13 SPase I inhibitors 14 and ClpP protease inhibitors, 15 and have attracted other mechanistic 16,17 and synthetic efforts. [18][19][20] β-Sultam chemistry been a focus of our research for some time.…”

“…[18][19][20] β-Sultam chemistry been a focus of our research for some time. [6][7][8][9][10]12,13,17 …”