Anti-Inflammatory Action and Mechanisms of Resveratrol

Meng, Tiantian; Xiao, Dingfu; Muhammed, Arowolo; Deng, Juying; Chen, Liang; He, Jianhua

doi:10.3390/molecules26010229

Cited by 333 publications

(235 citation statements)

References 138 publications

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“…We, therefore, conclude that our low dose of 5 mg/kg was not sufficient to increase gene expression of Sirt1 and therefore the results seen in our cohort are likely attributed to effects on inflammation and are therefore not mediated by Sirt1. This effect was also observed for NF-κB1 and NF-κB2 which were unchanged by resveratrol treatment in the mdx mice again suggesting that resveratrol's effects in mdx mice are due to its ability to suppress inflammation, perhaps through its effects on other signalling targets such as the p38 MAPK pathways [34]. Overall resveratrol has shown potential to reduce pathology in the mdx mouse model of DMD and highlights the need for this to be tested clinically.…”

Section: Discussionmentioning

confidence: 69%

Resveratrol Promotes Hypertrophy in Wildtype Skeletal Muscle and Reduces Muscle Necrosis and Gene Expression of Inflammatory Markers in Mdx Mice

et al. 2021

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Duchenne muscular dystrophy (DMD) is a progressive fatal neuromuscular disorder with no cure. Therapies to restore dystrophin deficiency have been approved in some jurisdictions but long-term effectiveness is yet to be established. There is a need to develop alternative strategies to treat DMD. Resveratrol is a nutraceutical with anti-inflammatory properties. Previous studies have shown high doses (100–400 mg/kg bodyweight/day) benefit mdx mice. We treated 4-week-old mdx and wildtype mice with a lower dose of resveratrol (5 mg/kg bodyweight/day) for 15 weeks. Voluntary exercise was used to test if a lower dosage than previously tested could reduce exercise-induced damage where a greater inflammatory infiltrate is present. We found resveratrol promoted skeletal muscle hypertrophy in wildtype mice. In dystrophic muscle, resveratrol reduced exercise-induced muscle necrosis. Gene expression of immune cell markers, CD86 and CD163 were reduced; however, signalling targets associated with resveratrol’s mechanism of action including Sirt1 and NF-κB were unchanged. In conclusion, a lower dose of resveratrol compared to the dosage used by other studies reduced necrosis and gene expression of inflammatory cell markers in dystrophic muscle suggesting it as a therapeutic candidate for treating DMD.

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Section: Discussionmentioning

confidence: 69%

Resveratrol Promotes Hypertrophy in Wildtype Skeletal Muscle and Reduces Muscle Necrosis and Gene Expression of Inflammatory Markers in Mdx Mice

et al. 2021

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“…Resveratrol also shows in vitro and in vivo anti-inflammatory activity against Aβtriggered microglial activation, via downregulation of the TLR4/NF-κB/STAT signaling cascade [20,39]. The findings described above illustrate how the beneficial effects of resveratrol are largely associated with its anti-inflammatory activity, in decreasing the serum levels of inflammatory factors such as TNF-α, IL-1β, and IL-6, and suppressing the p38-MAPK and NF-κB pathways [40]. Nevertheless, current research on the benefits of resveratrol for eye health have proven to be inconclusive.…”

Section: Discussionmentioning

confidence: 84%

Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model

Hsu

Chen

Wang

et al. 2021

CIMB

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Resveratrol is a key component of red wine and other grape products. Recent studies have characterized resveratrol as a polyphenol, and shown its beneficial effects on cancer, metabolism, and infection. This study aimed to obtain insights into the biological effects of resveratrol on myopia. To this end, we examined its anti-inflammatory influence on human retinal pigment epithelium cells and in a monocular form deprivation (MFD)-induced animal model of myopia. In MFD-induced myopia, resveratrol increased collagen I level and reduced the expression levels of matrix metalloproteinase (MMP)2, transforming growth factor (TGF)-β, and nuclear factor (NF)-κB expression levels. It also suppressed the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. Resveratrol exhibited no significant cytotoxicity in ARPE-19 cells. Downregulation of inflammatory cytokine production, and inhibition of AKT, c-Raf, Stat3, and NFκB phosphorylation were observed in ARPE-19 cells that were treated with resveratrol. In conclusion, the findings suggest that resveratrol inhibits inflammatory effects by blocking the relevant signaling pathways, to ameliorate myopia development. This may make it a natural candidate for drug development for myopia.

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“…Resveratrol has many different healing and preventive properties, including antioxidant, anti-inflammatory, antimicrobial, chemopreventive, and immunomodulatory effects [25][26][27][28][29][30]. It may affect the activity of the nicotine adenine dinucleotide (NAD)+dependent histone/protein deacetylases (sirtuins) involved in modulating numerous cellular pathways which are related to stress responses and aging, e.g.…”

Section: Biological Activity Of Resveratrolmentioning

confidence: 99%

The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases—A Literature Review

Szulc-Musioł

Sarecka-Hujar

2021

Pharmaceutics

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In recent years, polyphenols have been extensively studied due to their antioxidant, anticancer, and anti-inflammatory properties. It has been shown that anthocyanins, flavonols, and flavan-3-ols play an important role in the prevention of bacterial infections, as well as vascular or skin diseases. Particularly, resveratrol, as a multi-potent agent, may prevent or mitigate the effects of oxidative stress. As the largest organ of the human body, skin is an extremely desirable target for the possible delivery of active substances. The transdermal route of administration of active compounds shows many advantages, including avoidance of gastrointestinal irritation and the first-pass effect. Moreover, it is non-invasive and can be self-administered. However, this delivery is limited, mainly due to the need to overpassing the stratum corneum, the possible decomposition of the substances in contact with the skin surface or in the deeper layers thereof. In addition, using resveratrol for topical and transdermal delivery faces the problems of its low solubility and poor stability. To overcome this, novel systems of delivery are being developed for the effective transport of resveratrol across the skin. Carriers in the micro and nano size were demonstrated to be more efficient for safe and faster topical and transdermal delivery of active substances. The present review aimed to discuss the role of resveratrol in the treatment of skin abnormalities with a special emphasis on technologies enhancing transdermal delivery of resveratrol.

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Anti-Inflammatory Action and Mechanisms of Resveratrol

Cited by 333 publications

References 138 publications

Resveratrol Promotes Hypertrophy in Wildtype Skeletal Muscle and Reduces Muscle Necrosis and Gene Expression of Inflammatory Markers in Mdx Mice

Resveratrol Promotes Hypertrophy in Wildtype Skeletal Muscle and Reduces Muscle Necrosis and Gene Expression of Inflammatory Markers in Mdx Mice

Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model

The Use of Micro- and Nanocarriers for Resveratrol Delivery into and across the Skin in Different Skin Diseases—A Literature Review

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