Anti-infective mechanisms induced by a probiotic Lactobacillus strain against Salmonella enterica serovar Typhimurium infection

LeBlanc, Alejandra de Moreno de; Castillo, Natalia Alejandra; Perdigón, Gabriela

doi:10.1016/j.ijfoodmicro.2010.01.020

Cited by 86 publications

(64 citation statements)

References 44 publications

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“…Some probiotics stimulated the immune system (de Moreno de LeBlanc et al, 2010) and other had anti-allergic or anti-inflammatory effects (Mileti et al, 2009). However, till now, no reports of the effects of probiotics on the immune system in rams have been documented.…”

Section: Cd25mentioning

confidence: 99%

Effect of probiotic strains mixture administration on serum interleukins concentration, lymphocyte proliferation and DNA damage in rams

Abdelrazek¹,

Yusuf²,

Ismail³

et al. 2015

J. Anim. Feed Sci.

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Section: Cd25mentioning

confidence: 99%

Effect of probiotic strains mixture administration on serum interleukins concentration, lymphocyte proliferation and DNA damage in rams

Abdelrazek¹,

Yusuf²,

Ismail³

et al. 2015

J. Anim. Feed Sci.

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“…In a previous study, live ingestion of probiotics in sufficient amounts was shown to have a positive effect on the host via stimulation of the non-immune response and through the enhancement of immune protection (Böhmer et al, 2006). Probiotics use has also been linked to the enhancement of gut microflora, resulting in improved health status, gut microflora balance and increased resistance to pathogenic agents (Böhmer et al, 2006;de Moreno de LeBlanc et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…During this process, a protective effect was exerted via multiple immune and nonimmune mechanisms and by direct antimicrobial activity against pathogens. This resulted in increased phagocytosis and modified cytokine levels via different cell populations (de Moreno de LeBlanc et al, 2010;Latvala et al, 2008;Vizoso Pinto et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Influence of Probiotics on Coccidia, <i>H</i>. Contortus and Markers of Infection in Goats

Gyenai¹,

Worku²,

Tajkarimi³

et al. 2016

American Journal of Animal and Veterinary Sciences

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Immunostimulants can induce nonspecific resistance against parasites. The use of probiotics to control development of animal gastrointestinal parasites could help reduce the risks of infestation. In this study, we investigated the effects of probiotics administration on gastrointestinal parasites coccidia, H. contortus and markers of infection. A cocktail of probiotics mix including Bifidobacterium longum, Bifidobacterium breve, Lactobacillus acidophilus, Lactobacillus reuteri and Lactobacillus rhamnosus (8.5 log CFU/mL) was drenched daily to three months-old male Spanish Boer kid-goats (n = 3) till four weeks of age. Control group of age matched kid-goats received sterile water daily for a 4-week period. Body weight, Fecal Egg Count, FAMACHA scores, Packed Cell Volume (PCV) and White Blood Cell Differential Count was determined weekly. Denaturing Gradient Gel Electrophoresis (DGGE) was used to monitor fecal bacteria using bacteria 16 sec rDNA primers. Proinflammatory cytokines, Prostaglandin2 (PGE2) and Immunoglobulin E levels in plasma were evaluated using commercial ELISAs. Results showed no significant difference in PCV, body weight, White Blood Cell Differential Count, FAMACHA score, PGE2 and IgE levels between probiotic drenched and control. However, eggs per gram were increased significantly (p<0.05) probiotics drenched 100, 90 and 120% at weeks 2, 3 and 4 for haemonchus and 70% for coccidia at week 3 respectively. An increase of 50 to 300% in pro-inflammatory cytokines was observed for probiotic drenched over control at weeks 2, 3 and 4. Pro inflammatory cytokine levels were significantly highest (p<0.05) for IFNr, G-CSF and IL-1α when pre-treatment levels were compared to week 4 for probiotic drenched. Results from PCR-DGGE analysis showed significantly increased fecal microbial DNA for probiotics drenched (p<0.05), with no difference in band pattern and staining intensity. Although increases in H. contortus count and Pro-inflammatory cytokine levels were observed, probiotics drenching had no effect against coccidia or H. contortus. This study supports the idea that use of probiotics in ruminants may be impacted by lack of microbial retention in the rumen. Further studies on establishment and retention are needed.

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“…40 In vivo study using a mouse model demonstrated that continued administration of L. casei CRL diminished Salmonella counts in the intestine and extraintestinal dissemination. 41 L. casei Shirota strain also protected mice against lethal infection with multi-drug resistant S. Typhimurium DT104. 42 Besides the antimicrobial effects, probiotics also increased the performance employed to create bioengineered probiotics.…”

Section: Recombinant Bioengineered Probioticsmentioning

confidence: 96%

Bioengineered probiotics, a strategic approach to control enteric infections

Amalaradjou

Bhunia

2013

Bioengineered

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Anti-infective mechanisms induced by a probiotic Lactobacillus strain against Salmonella enterica serovar Typhimurium infection

Cited by 86 publications

References 44 publications

Effect of probiotic strains mixture administration on serum interleukins concentration, lymphocyte proliferation and DNA damage in rams

Effect of probiotic strains mixture administration on serum interleukins concentration, lymphocyte proliferation and DNA damage in rams

Influence of Probiotics on Coccidia, <i>H</i>. Contortus and Markers of Infection in Goats

Bioengineered probiotics, a strategic approach to control enteric infections

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