Anti‐infective Agents: The Example of Antibacterial Drug Leads

Macedo, Maíra Bidart de; Clais, Sofie; Lanckacker, Ellen; Maes, Louis; Lima, Émerson Silva; Cos, Paul

doi:10.1002/9781118930717.ch11

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…The World Health Organization reported that infectious diseases are responsible for one third of global mortality and that they still pose a major threat to public health in numerous countries (WHO, 2017). Their impact is more evident in developing countries due to the limited accessibility to medicines and the emergence of widespread drug resistance (Macedo et al, 2015). The plant kingdom represents the source of various medicines.…”

Section: Introductionmentioning

confidence: 99%

ANTIBACTERIAL ACTIVITY OF WATER AND ETHANOLIC EXTRACTS OF Bauhinia variegata LEAVES

El-Moula

Awad

El-Sayed

et al. 2019

Zagazig Journal of Agricultural Research

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Phytochemicals isolated from medicinal plants are known to be effective in treating bacterial infections. The antibacterial activities of the ethanol and water leaf extracts of Bauhinia variegata were tested. Antibacterial effects of crude extracts were performed using modified Kirby-Bauer disc diffusion technique to determine the zone of inhibition. The extracts were tested for the antibacterial activities against Gram-positive bacteria (Sarcina ventriculi) and Gram-negative bacteria (Serratia marcescens). The results demonstrated that both ethanol and water leaf extracts of Bauhinia variegata have shown strong inhibition zone against Serratia marcescens and Sarcina ventriculi compared to control). This medicinal plant could be developed into affordable and safe standardized herbal products and may serve as a source of new molecules for broad-spectrum antimicrobial agents. Our results revealed that Bauhinia variegata leaves contains total phenolic contents (453 mgGAE/ g), flavonoid 166 mg QE/g and total alkaloid 1.674 g/100g. Also Bauhinia variegata leaf extracts showed highly antioxidant activity.

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Section: Introductionmentioning

confidence: 99%

ANTIBACTERIAL ACTIVITY OF WATER AND ETHANOLIC EXTRACTS OF Bauhinia variegata LEAVES

El-Moula

Awad

El-Sayed

et al. 2019

Zagazig Journal of Agricultural Research

View full text Add to dashboard Cite

show abstract

“…The World Health Organization reported that infectious diseases are responsible for one third of global mortality and that they still pose a major threat to public health in numerous countries (WHO, 2017). Their impact is more evident in developing countries due to the limited accessibility to medicines and the emergence of widespread drug resistance (Macedo et al, 2015). The increasing resistance of microorganisms to available antimicrobial agents is one of the major concerns for scientists and clinicians worldwide, and has become a global problem in the last years (Abad et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Over the past decade, interest in the search for antimicrobial natural products has risen (Ahmad et al, 2006). From all possible sources of natural products, plants are considered as the most promising product (Macedo et al, 2015). Croton is the second most extensive genus of Euphorbiaceae with approximately 1250 species (Costa et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITY OF Codiaeum variegatum LEAVES

mohamed

El-Masry

Awad

et al. 2019

Zagazig Journal of Agricultural Research

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Natural substances of botanical origin have been important in African traditional medical practice. They have been used for various illnesses such as infections. Infectious diseases caused by pathogenic bacteria affect many communities and the treatment was made difficult partly because of antibiotic resistant strains. Phytochemicals isolated from medicinal plants are known to be effective in treating bacterial infections. The antibacterial activities of the ethanol and water leaf extracts of Codiaeum variegatum were tested. Antibacterial effects of crude extracts were performed using modified Kirby-Bauer disc diffusion technique to determine the zone of inhibition. The extracts were tested for the antibacterial activities against Gram-positive bacteria (Bacillus subtilis) and Gramnegative bacteria (Serratia marcescens). The results demonstrated that both of ethanol and water leaf crude extracts of Codiaeum variegatum have shown strong zone of inhibition against Serratia marcescens (20 mm) and Bacillus subtilis (12 mm) compared to control. This medicinal plant could be developed into affordable and safe standardized herbal products and may serve as a source of new molecules for broad-spectrum antimicrobial agents.

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Anti‐infective Agents: The Example of Antibacterial Drug Leads

Cited by 2 publications

References 30 publications

ANTIBACTERIAL ACTIVITY OF WATER AND ETHANOLIC EXTRACTS OF Bauhinia variegata LEAVES

ANTIBACTERIAL ACTIVITY OF WATER AND ETHANOLIC EXTRACTS OF Bauhinia variegata LEAVES

CHEMICAL COMPOSITION AND ANTIBACTERIAL ACTIVITY OF Codiaeum variegatum LEAVES

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