Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials

Mousavi, Seyed Mohammad; Karimi, Elmira; Hajishafiee, Maryam; Milajerdi, Alireza; Amini, Mohammad Reza; Esmaillzadeh, Ahmad

doi:10.1080/10408398.2019.1678012

Cited by 29 publications

(29 citation statements)

References 55 publications

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“…ZSHLF, a traditional Chinese compound formulated according to clinical experience, has been used clinically to treat hypertensive LVH for more than 10 years. Much evidence suggests that ZSHLF has many biological properties, including antihypertensive properties; for example, it improves hemorheology and cardiac function, and reverses LVH (Liu et al, 2013;Zhang et al, 2016;Lu et al, 2019;Mousavi et al, 2019;Yang and Lao, 2019).…”

Section: Discussionmentioning

confidence: 99%

Zi Shen Huo Luo Formula Enhances the Therapeutic Effects of Angiotensin-Converting Enzyme Inhibitors on Hypertensive Left Ventricular Hypertrophy by Interfering With Aldosterone Breakthrough and Affecting Caveolin-1/Mineralocorticoid Receptor Colocalization and Downstream Extracellular Signal-Regulated Kinase Signaling

et al. 2020

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ALD-induced cardiomyocytes (H9c2 cells) and cardiac fibroblasts were treated with ZSHLF-containing serum, which suppressed ALD-induced cardiomyocyte hypertrophy and cardiac fibroblast proliferation, increased mineralocorticoid receptor (MR) and Cav-1 colocalization and decreased phosphorylated epidermal growth factor receptor (pEGFR) and phosphorylated extracellular signal-regulated kinase (pERK) protein expression the cells. In conclusion, ZSHLF can interfere with ABT and affect the pathological role of ALD by affecting MR and Cav-1 interactions and EGFR/ERK signaling pathway. These effects represent a possible mechanism by which ZSHLF improves the efficacy of angiotensinconverting enzyme inhibitors (ACEIs) in hypertensive LVH treatment. However, the major bioactive components or metabolites responsible for the effects and the implications of these findings in patients need further verification.

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Section: Discussionmentioning

confidence: 99%

Zi Shen Huo Luo Formula Enhances the Therapeutic Effects of Angiotensin-Converting Enzyme Inhibitors on Hypertensive Left Ventricular Hypertrophy by Interfering With Aldosterone Breakthrough and Affecting Caveolin-1/Mineralocorticoid Receptor Colocalization and Downstream Extracellular Signal-Regulated Kinase Signaling

et al. 2020

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“…A study conducted on MetS patients, showed a significant reduction in BP after cinnamon assumption with consequent decrease in MetS prevalence compared to the control group [111]. A recent meta-analysis evaluating the effects of oral cinnamon supplementation on BP, confirmed its hypotensive effect on both systolic and diastolic BP [218].…”

Section: Endothelial Dysfunctionmentioning

confidence: 95%

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

et al. 2021

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Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient’s compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.

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“…One systematic review from Mousavi et al (76) discussed nine trials that enrolled a total of 641 subjects. Cinnamon induced drop in SBP (Weighted Mean Differences (WMD): −6.23 mmHg and DBP (WMD: −3.93 mmHg), which were optimally detected in trials using < 2 g cinnamon, more than 12 weeks length of experimentation, and < 50 years-old participants.…”

Section: Effects Of Cinnamon Mangosteen and Curcumin On Blood Pressmentioning

confidence: 99%

“…However, no non-linear association was concluded between study duration and cinnamon supplementation dosage in the aforementioned systolic blood pressure value. Although cinnamon shows potential effects in controlling hypertension, further studies are necessary to be conducted in order to confirm its reviewed therapeutic effectiveness (76).…”

Section: Effects Of Cinnamon Mangosteen and Curcumin On Blood Pressmentioning

confidence: 99%

Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies

Arozal

Louisa

Soetikno

2020

Front. Cardiovasc. Med.

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Increased prevalence of metabolic syndrome (MetS) in the world influences quality of health in all respective countries, including Indonesia. Data from Indonesian Family Life Survey reported in 2019 showed that the prevalence of MetS in Indonesia currently is 21.66%, estimated with the provincial incidence ranging up to 50%; additionally, the most common components of MetS discovered in Indonesia were poor high-density lipoprotein (HDL) cholesterol and hypertension. Management treatment of MetS involves a combination of lifestyle changes and pharmacological interventions to decrease cerebrovascular disease. Various natural substances have been shown to govern any cardiovascular or metabolic disorders through different mechanisms, such as triggering anti-inflammation, lipid profile correction, sensitization of insulin reception, or blood glucose control. In Indonesia, the utilization of natural compounds is part of the nation's culture. The community widely uses them; even though in general, their effectiveness and safety have not been thoroughly assessed by rigorous clinical trials. Scientific evidence suggested that cinnamon, mangosteen, and curcumin, as well as their derived components possess a broad spectrum of pharmacological activity. In this review, an enormous potential of cinnamon, mangosteen, and curcumin, which originated and are commonly used in Indonesia, could be treated against MetS, such as diabetes, hyperlipidemia, hypertension, and obesity. The findings suggested that cinnamon, mangosteen, curcumin and their derivatives may reflect areas of promise in the management of MetS.

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Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials

Cited by 29 publications

References 55 publications

Natural Bioactive Compounds Useful in Clinical Management of Metabolic Syndrome

Selected Indonesian Medicinal Plants for the Management of Metabolic Syndrome: Molecular Basis and Recent Studies

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