Anti-hypertensive and vasodilatory effects of amended Banxia Baizhu Tianma Tang

Tan, Chu Shan; Loh, Yean Chun; Ng, Chiew Hoong; Ch’ng, Yung Sing; Asmawi, Mohd Zaini; Ahmad, Mariam; Yam, Mun Fei

doi:10.1016/j.biopha.2017.11.021

Cited by 23 publications

(10 citation statements)

References 18 publications

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“…Furthermore, this TCM formula demonstrated optimal blood pressure lowering effect in in vivo spontaneous hypertensive rat (SHR) models. According to the results shown, the systolic (SBP) and diastolic blood pressure (DBP) as well as the mean arterial pressure (MAP) were successfully decreased after 28 days of sub-chronic oral administration of this TCM formula combination, and this formula was then termed as Banxia Baizhu Tianma Tang [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

Orthogonal Stimulus-Response as a Tool to Formulate Traditional Chinese Medicinal Herbal Combination

Loh

Tan

et al. 2018

J Pharmacopuncture

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Section: Resultsmentioning

confidence: 99%

Orthogonal Stimulus-Response as a Tool to Formulate Traditional Chinese Medicinal Herbal Combination

Loh

Tan

et al. 2018

J Pharmacopuncture

Self Cite

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“…The production of these second messengers are strictly dependent on the activation of various types of the receptors that are located on the vasculature including EDRFs, enzyme-linked, G-protein-coupled, and channel-linked receptors. According to literatures, the vasodilative receptors are more frequently being included in the experimental study on mechanisms of actions of test compounds rather than vasoconstrictive receptors [ 86 , 87 , 88 , 89 , 90 , 91 ]. Therefore, following the current trend of pharmacological research, all the vasodilation-mediated receptors pathways that should be investigated during the mechanisms of actions study of test compounds were suggested at this section.…”

Section: General Integration Of Vasodilative Receptorsmentioning

confidence: 99%

“…Furthermore, PGI 2 produced by COX in the vascular endothelium will bind to the IP receptor that located on the membrane of the adjacent VSMCs, and causes the activation of AC and up-regulation of cAMP; hence, this results in vasodilation. Therefore, NO/sGC/cGMP and COX are major pathways that should be investigated during the mechanisms of actions study on vasodilatory effects of test compounds [ 5 , 86 ].…”

Section: General Integration Of Vasodilative Receptorsmentioning

confidence: 99%

“…The activation of IP 3 R is strictly dependent on the activation of G q α-protein-coupled receptors, which allows the Ca 2+ ions released from the store of sacroplasmic reticulum into the cytosol. Therefore, all these channel-linked pathways should be investigated during the mechanisms of actions study on vasodilatory effects of test compounds [ 5 , 86 , 87 , 88 , 89 , 90 , 91 ].…”

Section: General Integration Of Vasodilative Receptorsmentioning

confidence: 99%

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Overview of the Microenvironment of Vasculature in Vascular Tone Regulation

Loh

Tan

Ch’ng

et al. 2018

IJMS

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Hypertension is asymptomatic and a well-known “silent killer”, which can cause various concomitant diseases in human population after years of adherence. Although there are varieties of synthetic antihypertensive drugs available in current market, their relatively low efficacies and major application in only single drug therapy, as well as the undesired chronic adverse effects associated, has drawn the attention of worldwide scientists. According to the trend of antihypertensive drug evolution, the antihypertensive drugs used as primary treatment often change from time-to-time with the purpose of achieving the targeted blood pressure range. One of the major concerns that need to be accounted for here is that the signaling mechanism pathways involved in the vasculature during the vascular tone regulation should be clearly understood during the pharmacological research of antihypertensive drugs, either in vitro or in vivo. There are plenty of articles that discussed the signaling mechanism pathways mediated in vascular tone in isolated fragments instead of a whole comprehensive image. Therefore, the present review aims to summarize previous published vasculature-related studies and provide an overall depiction of each pathway including endothelium-derived relaxing factors, G-protein-coupled, enzyme-linked, and channel-linked receptors that occurred in the microenvironment of vasculature with a full schematic diagram on the ways their signals interact. Furthermore, the crucial vasodilative receptors that should be included in the mechanisms of actions study on vasodilatory effects of test compounds were suggested in the present review as well.

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“…BBTT has been often used in the treatment of H-type hypertension in clinical practice in China with uncertain effects. [ 19 , 20 ] However, to our knowledge, there is no systematic review of its efficacy and safety in the treatment of H-type hypertension. Therefore, we propose the current protocol to evaluate the effectiveness and safety of BBTT on H-type hypertension, providing a reference for clinical use.…”

Section: Introductionmentioning

confidence: 99%