Anti-hyperlipidemic Activity of Cucumis Melo Fruit Peel Extracts in High Cholesterol Diet Induced Hyperlipidemia in Rats

Bidkar, Jayant S.; Ghanwat, Dhanaji Dadaso; Bhujbal, Madhuri D.; Dama, Ganesh

doi:10.1515/1553-3840.1580

Cited by 24 publications

(11 citation statements)

References 9 publications

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“…SD are most common cause of CHDs and occur sporadic or familial forms [20,21]. Familial forms may follow atypical patterns of inheritance resulting in variable phenotype, such that TBX5 gene ; detected in the recruited subjects with SD.…”

Section: Discussionmentioning

confidence: 99%

A Tbx5 Nonsense Mutation in Siblings With Divergent Phenotypes Associated With Isolated Septal Defects

Borkar

Nayak

Shetty

et al. 2017

Asian J Pharm Clin Res

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Objective: Heart septal defects (HSD) account for 50% of the congenital heart malformations and are characterized by the hole in the wall of tissue which separates the heart chambers. The known causes of the SD are multifactorial and complex inheritance.Methods: Isolated 15 subjects with ostium secundum atrial SD (OS-ASD) and one subject with perimembranous ventricular SD (VSD) among 125 clinically diagnosed SD were included in the study. Sanger sequencing was performed for all the exons of TBX5 genes using genomic DNA of these patients.Results: Sequence variation c.444 G>A substitution, leads to the alteration of tryptophan residue into premature stop codon at codon 148. We observed a divergent phenotype within a family of four, where one sibling and the mother had OS-ASD, another sibling had phenotype of perimembranous VSD, and the father had normal genotype. Conclusion:We believe that this novel sequence variant in TBX5 gene is one of the factors in the SD and may hold a key determining the role of TBX5 gene in the heart development.

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Section: Discussionmentioning

confidence: 99%

A Tbx5 Nonsense Mutation in Siblings With Divergent Phenotypes Associated With Isolated Septal Defects

Borkar

Nayak

Shetty

et al. 2017

Asian J Pharm Clin Res

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“…Dixit and Kar () reported that peels from three melon varieties nearly reversed alloxan‐induced diabetes in mice. Bidkar, Ghanwat, Bhujbal, and Dama () showed that the observed anticholesterol activity of methanolic melon peel extracts in rats on a high‐fat diet was equivalent to that observed with the drug atorvastatin. Finally, Rolim et al.…”

Section: Resultsmentioning

confidence: 92%

Phenolic Content and Antioxidant Activity of Extracts of 12 Melon (Cucumis melo) Peel Powders Prepared from Commercial Melons

Ganji

Singh

Friedman

2019

Journal of Food Science

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Melons are a diverse group of fresh, dessert fruits that includes orange flesh cantaloupe, green flesh honeydew, and mixed hybrid melons. As part of an effort to discover potential health benefits of fruit and vegetable peels that are considered to be byproducts of food processing, we determined the total phenolic content and antioxidative activities of methanolic extracts of the powdered peels of the following commercial melon (Cucumis melo) varieties sold at retail markets in California that were imported from Mexico and Honduras: nonorganic Canary, Charentias, Hani Gold, Vine ripened, and Santa Claus; and organic Ambrosia, Cantaloupe, Galia, Goddess, Ham, Honeydew, and Tuscan. The total phenolic content (in mg gallic acid equivalents/g extract) ranged from 0.69 (Tuscan) to 2.96 (Galia) or 4.3‐fold variation from lowest to highest value. The antioxidative activity (in mg ascorbic acid equivalents/mL extract) ranged from 0.13 (organic Tuscan) to 0.26 (organic Galia). Similar results were observed using the ABTS antioxidative assay. The content of the phenolic and flavonoid compounds 3‐hydroxybenzoic acid, chlorogenic acid, neochlorogenic acid, isovanillic acid, apigenin‐7‐α‐glucoside, luteolin‐7‐o‐glucoside, and quercetin‐3‐galactoside in three melon flesh samples (nonorganic and organic Galia from Honduras and organic Galia from Mexico and two peel samples (Mexican organic peel and flesh) were analyzed using HPLC. The results suggest that the peel from the Honduran Galia melon with the highest antioxidative activity merits further study to investigate potential health properties. Potential nutritional and health benefits of melon peels, Seeds, and their bioactive compounds are discussed. Practical Application The peel from the Honduran Galia melon variety merits further study for potential health benefits, including antioxidative, anticholesterol, and antidiabetic activities, and stimulation of thyroid function, as reported for peels from other melon varieties, as well as antibiotic activities against pathogenic bacteria, protozoa, and viruses.

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“…Antimicrobial activity [101] , Antioxidative and cytotoxic activity [102][103][104] , Anti-hyperlipidemic activity [105] , Thyroid stimulatory and antiperoxidative activity [106] , Anthelmintic property [107] 4.…”

Section: Diuretic Activitymentioning

confidence: 99%

A Review on Medicinal Plants Used as Diuretics From Karnataka State

Paarakh¹

2017

WJPPS

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Medicinal herbs are the significant source for treatment of number of diseases, one such is Diuretics. Mono and poly-herbal preparations have been used as diuretics. According to estimate, more than 650 mono and poly-herbal preparations in the form of decoction, tincture, tablets and capsules are from more than 75 plants that are in clinical use. There exist a large number of studies which supports the diuretic effects of traditional herbal medicines. Herbal medicine have been the most commonly prescribed medications for diuretics. They inhibit electrolyte reabsorption from the lumen of the nephron, increasing osmolarity, enhancing water and electrolyte excretion. It is important to note that there is a delicate balance between dietary sodium intake and sodium loss. If the balance is compromised and there is a greater intake of sodium into the body, but not enough sodium removal, complications of fluid overload occur, such as oedema, pulmonary oedema or high blood pressure. When there is greater removal of sodium, but not enough sodium intake, complications of fluid depletion take place, such as renal failure or reduced output of blood from the heart. The ability to induce a negative fluid balance has made diuretics useful in the treatment of a variety of conditions, particularly in hypertension and oedematous states. This review gives information about few herbal plants which are used traditionally in Karnataka as diuretics. There are a large number of studies which supports the diuretic effects of traditional herbal medicines which is presented along with chemical constituents and other pharmacological action of the plants.

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Anti-hyperlipidemic Activity of Cucumis Melo Fruit Peel Extracts in High Cholesterol Diet Induced Hyperlipidemia in Rats

Cited by 24 publications

References 9 publications

A Tbx5 Nonsense Mutation in Siblings With Divergent Phenotypes Associated With Isolated Septal Defects

A Tbx5 Nonsense Mutation in Siblings With Divergent Phenotypes Associated With Isolated Septal Defects

Phenolic Content and Antioxidant Activity of Extracts of 12 Melon (Cucumis melo) Peel Powders Prepared from Commercial Melons

A Review on Medicinal Plants Used as Diuretics From Karnataka State

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