Anti-Hyperglycemic, Anti-Hyperlipidemic and Antioxidant Potential of Alcoholic-Extract of Sida cordifolia (Areal Part) in Streptozotocin-Induced-Diabetes in Wistar-Rats

Abstract

Sida cordifolia is a shrub found throughout the tropical and sub-tropical plains. All parts of the plant are used as anti-rheumatic, antipyretic, anti-asthmatic, laxative, diuretic, vasorelaxative, hypotensive, central nervous system depressant, antioxidant, analgesic and hypoglycemic. The present study was aimed to evaluate the hypoglycemic, anti-hyperlipidemic and antioxidant potential of alcoholic-extract obtained from areal part of S. cordifolia in streptozotocin-induced-diabetes in wistar-rats. Diabetes was induced with streptozotocin at the intra-peritoneal dose of 55 mg/kg. Diabetic rats were treated with alcoholic extract of S. cordifolia at dosage of 200, 400 mg/kg and glibenclamide (5 mg/kg) after sub-acute administration for 28 days. Alcoholic extract of S. cordifolia at 400 mg/kg significantly improved the body-weight whereas significantly decreased the blood glucose level in diabetic rats. However at 400 mg/kg, the alcoholic extract of S. cordifolia showed beneficial effect indicating significant decrease in total cholesterol, triglycerides, low density lipids, plasma-creatinine, plasma-urea nitrogen and lipidperoxidation and a significant increase in high density lipid-level in diabetic rats. Interestingly at 400 mg/kg, a significant increase in antioxidant enzymes such as catalase and superoxide-dismutase-activity was seen in the diabetic rats. The dose 200 mg/kg of alcoholic extract of S. cordifolia showed non-significant change in diabetic rats. The above therapeutic-potential of alcoholic extract of areal parts of plant may be because of the presence of bioactive compounds such as glycosides, resins, alkaloids, sterols, saponins and flavonoids. Thus, the findings of the present study indicate that the alcoholic extract of S. cordifolia at dosage level of 400 mg/kg produces anti-diabetic effect in the streptozotocin-induced diabetes in wistar-rats.

Secondary metabolite compounds from Sida genus and their bioactivity

“… Ahmad et al. (2014) documented that the alcoholic extract of S. cordifolia displayed antihyperglycemic action when administered to streptozotocin-induced diabetic rats.…”

“…The MIC (minimal inhibitory concentration) and MFC (minimal fungicidal concentration) were identified toward Candida krusei isolates. Ahmad et al (2014) documented that the alcoholic extract of S. cordifolia displayed antihyperglycemic action when administered to streptozotocin-induced diabetic rats. 4.12.…”

Phyto-Pharmacological Properties of Sida Cordifolia: A Review of Folklore Use and Pharmacological Activities

“…Mahrukh et al [43] evaluated hypoglycemic, anti-hyperlipidemic, and antioxidant potential of alcoholic extract of S. cordifolia at a dose of (200 and 400 mg/kg) in streptozotocin-induced diabetes rats at the dose of 55 mg/kg. At a dose of 400 mg/kg S. cordifolia extracts showed significant reduction of the blood glucose level in diabetic rats and there was a decrease in total cholesterol, triglycerides, low-density lipid, plasma creatine, plasma-urea nitrogen.…”

Hypoglycemic, hypolipidemic, and wound healing potential of quercetin in streptozotocin-induced diabetic rats

“…[ 1 ] Diabetes is the third killer of humankind after tumor, and cardiovascular ailments as a result of its high pervasiveness, morbidity, and mortality. [ 2 ] The prevalence of diabetes has risen steeply with an increase of mortality and morbidity rates. [ 3 ] Diabetes is a worldwide epidemic with an expected worldwide prevalence of 246 million people in 2007 and is predicted to rise to 300 million by 2025.…”