Anti-hyperglycemic activity of Commelina communis L.: inhibition of α-glucosidase

Youn, Ji-Youn; Park, Hyo-Young; Cho, Kyung‐Hea

doi:10.1016/j.diabres.2003.08.015

Cited by 102 publications

(63 citation statements)

References 13 publications

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“…No significant difference (p > 0.05) of the IC 50 values were found between quercetagetin (180.11 ± 3.68 μmol/L) and quercetin (163.44 ± 3.44 μmol/L) for α-glucosidase inhibitory activity, but they were greatly higher than that of rutin (99.13 ± 1.99 μmol/L) and significantly (p < 0.05) lower than that of acarbose (810.85 ± 5.96 μmol/ L). The IC 50 value of acarbose (positive control) for α-glucosidase inhibitor was observed to be much higher, which was similar to the result from Youn et al (2004). In this study, quercetin and rutin were found to be about 5 and 8 times more effective than acarbose in inhibiting α-glucosidase inhibitory activity, respectively.…”

Section: Abtssupporting

confidence: 75%

In vitro antioxidant, anti-diabetic and antilipemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues

Wang

Chen

et al. 2016

J Food Sci Technol

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Quercetagetin, the major flavonoid in marigold (Tagetes erecta L.) inflorescence residues was extracted and purified. The content of quercetagetin after the purification was 89.91 ± 0.26 %. The in vitro antioxidant activity of quercetagetin and its potential in controlling diabetes mellitus and obesity were investigated and compared to quercetin and rutin. The 50 % inhibitory concentration (IC 50 ) values of quercetagetin on scavenging 1, 1-diphenyl-2-picrylhydrazyl (DPPH), 2,2-azinobis-(3-ethylbenzothiazolin-6-sulfonic acid) (ABTS) and hydroxyl radicals were 27.12 ± 1.31 μmol/L, 12.16 ± 0.56 μmol/L and 1833.97 ± 6.66 μmol/L, respectively. The IC 50 values of quercetagetin on α-glucosidase, α-amylase and pancreatic lipase were 180.11 ± 3.68 μmol/L, 137.71 ± 3.55 μmol/L and 2327.58 ± 12.37 μmol/L, respectively. These results indicated that quercetagetin exhibited strong in vitro antioxidant, anti-diabetic and antilipemic activities. Lineweaver-Burk plots analysis elucidated that quercetagetin inhibited α-glucosidase and α-amylase non-competitively, while its inhibition against pancreatic lipase was involved in a mixed-type pattern. Moreover, strong correlations were found between ABTS ·+ /DPPH · scavenging activities and lipase inhibitory activity (R 2 > 0.90), as well as ·OH scavenging activity and α-amylase inhibitory activity (R 2 = 0.8967).

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Section: Abtssupporting

confidence: 75%

In vitro antioxidant, anti-diabetic and antilipemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues

Wang

Chen

et al. 2016

J Food Sci Technol

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“…However, excessive free radical generation and/or depleted endogenous antioxidant defense system have been implicated (27).…”

Section: Discussionmentioning

confidence: 99%

“…Since most of the antidiabetic medications could have side effects (8), many studies have been conducted to identify natural substances that show antidiabetic activity with less side effects (22,27). Garlic and its products could be suitable candidates for antidiabetic agents via antioxidant effects (23).…”

Section: Discussionmentioning

confidence: 99%

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

Naderi

Mohaddes

Mohammadi

et al. 2015

Acta Physiologica Hungarica

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Since some complications of diabetes mellitus may be caused or exacerbated by an oxidative stress, the protective effects of garlic (Allium sativum) were investigated in the blood and heart of streptozotocin-induced diabetic rats. Twenty-eight male Wistar rats were randomly divided into four groups: control, garlic, diabetic, and diabetic+garlic. Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (50 mg/kg) in male rats. Rats were fed with raw fresh garlic homogenate (250 mg/kg) six days a week by gavage for a period of 6 weeks. At the end of the 6th week blood samples and heart tissues were collected and used for determination of glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA) and histological evaluation. Induction of diabetes increased MDA levels in blood and homogenates of heart. In diabetic rats treated with garlic, MDA levels decreased in blood and heart homogenates. Treatment of diabetic rats with garlic increased SOD, GPX and CAT in blood and heart homogenates. Histopathological finding of the myocardial tissue confirmed a protective role for garlic in diabetic rats. Thus, the present study reveals that garlic may effectively modulate antioxidants status in the blood and heart of streptozotocin induced-diabetic rats.

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“…Since most of antidiabetic medications could have side effects (2 7), many studies have been conducted to identify natural substances that show potent hypoglycemic activity with fewer side effects (28)(29)(30)(31). Eucommia ulmoides Oliver (Du-zhong) leaf (28,29), touchi extract (30), and Commelina communis (31) showed hypoglycemic activity in animal model of diabetes. Consumption of Du-zhong leaf extract for 6 weeks decreased blood glucose by 18.4% in db/db mice.…”

Section: Glycemic Controlmentioning

confidence: 99%

Effect of Garlic and Aged Black Garlic on Hyperglycemia and Dyslipidemia in Animal Model of Type 2 Diabetes Mellitus

Seo¹,

Gweon²,

Im³

et al. 2009

JFN

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Control of hyperglycemia and dyslipidemia is strongly correlated with decreased risk for cardiovascular disease, the most common and fatal diabetic complication. The purpose of this study is to determine the effects of garlic and aged black garlic on glycemic control and blood lipid profile in animal model of type 2 diabetes. Three week-old db/db mice (C57BL/Ks, n=21) were fed AIN-93G semipurified diet or diet containing 5% freeze-dried garlic or aged black garlic for 7 weeks after 1 week of adaptation. Fasting serum glucose, insulin, triglyceride, total cholesterol, and HDL-cholesterol and blood glycated hemoglobin were measured. Body weight and food intake of garlic and aged black garlic group were not significantly different from those of the control group. Fasting serum glucose and blood glycated hemoglobin levels were significantly decreased and insulin level was significantly increased in garlic group compared with control group (p<0.05). Consumption of aged black garlic significantly decreased homeostasis model assessment for insulin resistance (HOMA-IR) and tended to decrease serum glucose. Garlic consumption significantly decreased total cholesterol, while aged black garlic significantly reduced serum total cholesterol and triglyceride and increased HDL-cholesterol levels. These results suggest that garlic exerts hypoglycemic and hypocholesterolemic effect and aged black garlic improved insulin sensitivity and dyslipidemia in db/db mice.

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Anti-hyperglycemic activity of Commelina communis L.: inhibition of α-glucosidase

Cited by 102 publications

References 13 publications

In vitro antioxidant, anti-diabetic and antilipemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues

In vitro antioxidant, anti-diabetic and antilipemic potentials of quercetagetin extracted from marigold (Tagetes erecta L.) inflorescence residues

Preventive effects of garlic (Allium sativum) on oxidative stress and histopathology of cardiac tissue in streptozotocin-induced diabetic rats

Effect of Garlic and Aged Black Garlic on Hyperglycemia and Dyslipidemia in Animal Model of Type 2 Diabetes Mellitus

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