Anti-hypercholesterolemic impacts of barley and date palm fruits on the ovary of Wistar albino rats and their offspring

El‐Sayyad, Hassan I.; El-Shershaby, Effat M.; El‐Mansi, Ahmed A.; El-Ashry, Nermeen E.

doi:10.1016/j.repbio.2018.07.003

Cited by 17 publications

(14 citation statements)

References 112 publications

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“…T. gondii leads to a significant depletion in the glutathione level that can be an important factor in the T. gondii toxicity. The mechanism of hepatoprotection by AgNPs against T. gondii toxicity might be due to restoration of the GSH level, date seed and nabka have the potential to be used as a supplement for antioxidants, and this is agreement with the previous reports [39,52].…”

Section: Discussionsupporting

confidence: 92%

Anti-Toxoplasmaactivity of silver nanoparticles green synthesized withPhoenix dactyliferaandZiziphus spina-christiextracts which inhibits inflammation through liver regulation of cytokines in Balb/c mice

et al. 2019

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Toxoplasmosis constitutes a global infection caused by oblige intracellular apicomplexan protozoan parasite Toxoplasma gondii. Although often asymptomatic, infection can result in more severe, potentially life threatening symptoms particularly in immunocompromised individuals. The present study evaluated the anti-Toxoplasma effects in experimental animals of silver nanoparticles synthesized in combination with extracts of natural plants (Phoenix dactylifera and Ziziphus spina-christi) as an alternative method to standard sulfadiazine drug therapy. Liver functions estimated by and AST and ALT were significantly increased in T. gondii-infected mice compared with the control group as well as hepatic nitric oxide (NO), lipid peroxidation (LPO) levels and caused significant decrease in superoxide dismutase (SOD), catalase (CAT) and glutathione activities in the liver homogenates. Nanoparticles pretreatment prevented liver damage as determined by enzyme activity inhibition, in addition to significant inhibition of hepatic NO levels and significant elevation in liver SOD and CAT activities. Moreover, nanoparticle treatment significantly decreased hepatic LPO and NO concentrations and proinflammatory cytokines but significantly boosted the antioxidant enzyme activity of liver homogenate. In addition, histological examinations showed distinct alterations in the infected compared with untreated control groups. Conversely, nanoparticles pretreatment showed improvement in the histological features indicated by slight infiltration and fibrosis, minimal pleomorphism and less hepatocyte and degeneration. Furthermore, nanoparticles treatment induced a reduction in immunoreactivity to TGF-β and NF-κB in hepatic tissues. Therefore, the present study provides new insights into various natural plants that are used traditionally for the treatment of toxoplasmosis and other parasitic infections, which may be useful as alternative treatment option for T. gondii infections.

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Section: Discussionsupporting

confidence: 92%

Anti-Toxoplasmaactivity of silver nanoparticles green synthesized withPhoenix dactyliferaandZiziphus spina-christiextracts which inhibits inflammation through liver regulation of cytokines in Balb/c mice

et al. 2019

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“…All of the three clinical studies were conducted on PCOS patients, which supports the possibility of the natural products as protective agents against PCOS related infertility [ 106 , 107 , 108 ]. On the other hand, other materials were discovered to normalize ovarian function and menstrual cycle, and increase implantation success rate [ 12 , 98 ]. The natural products that were reviewed in this study showed elevation in FSH and LH, as well as significant increases in estrogen and progesterone which supported the overall promotion of reproductive activity [ 20 , 106 , 130 , 166 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, increased integrin and LIF were observed, and these mechanisms were found to be effective in alleviating existing diseases, recovering menstrual cycles, ovarian function, and creating optimal conditions for implantation. As in male infertility, a decrease in free radicals and an increase in antioxidant enzymes were observed in reports with natural products such as barley and royal jelly [ 98 , 102 ]. In addition, there have been experiments that showed that natural substances that helped control cholesterol and increase insulin sensitivity, which include cinnamon and Ficus asperifolia aqueous extract [ 13 , 99 ].…”

Section: Discussionmentioning

confidence: 99%

“…Administration of this natural product to SPF/ICR mice 5% of powder diet for 56 days upregulated the expression of PPAR, mDECR, and increased blood estradiol level. El-Sayyad, Hassan I H, et al demonstrated that barley ( Hordeum vulgare ) and date palm fruits ( Phoenix dactylifera ) protected the ovarian function from high cholesterol diet in Rattus rattus [ 98 ]. Supplement of those natural products, 10% of daily diet for 120 days, resulted in a considerable decline in MDA level associated with elevated CAT, SOD, and GST levels, which showed its antioxidative effects.…”

Section: Plant Extract and Infertilitymentioning

confidence: 99%

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Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Noh

Kim

et al. 2020

Antioxidants

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Infertility, a couple’s inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional therapies. The present study aimed to investigate the effects and the mechanisms of various natural products on infertility. We collected articles regarding infertility and natural products using the research databases PubMed and Google Scholar. Several natural products possess antioxidant properties and androgenic activities on productive factors and hormones. Antioxidants are the first defense barrier against free radicals produced by oxidative stress (OS). They remove reactive oxygen stress (ROS), reducing insulin resistance, total cholesterol, fat accumulation, and cancer growth. Moreover, various natural products increase endometrial receptivity and fertility ability showing androgenic activities on productive factors and hormones. For example, Angelica keiskei powder and Astragalus mongholicus extract showed anti-infertility efficacies in males and females, respectively. On the other hand, adverse effects and acute toxicity of natural products were also reported. Tripterygium glycoside decreased fertility ability both in males and females. Results indicate that management of infertility with natural products could be beneficial with further clinical trials to evaluate the safety and effect.

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“…Results showed that there was a significant improvement in hormonal regulation, strengthening of oocytes, and pregnancy [ 99 ]. Moreover, concomitant supplementation of barley and date fruit to the hypercholesterolemic mice group revealed remarkable improvement in ovarian function and structure [ 100 ]. Table 5 shows the summary of date palm and its constituents improving female fertility parameters.…”

Section: Date Palm Fruit Pollen and Seed: A Remedy Against Infertilitymentioning

confidence: 99%

Therapeutic Potential of Date Palm against Human Infertility: A Review

et al. 2021

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Male and female infertility is a global major health problem. Approximately 15% of couples of a reproductive age are unable to achieve the desired pregnancy within 12 months, despite daily unprotected sexual intercourse, and about 10% of infertilities have no specific reason worldwide. Currently, many researchers are interested to investigate the use of natural remedies for preventive and curative purposes of infertility. This review brings together some of the data on the nutritional characteristics of the date palm and its different parts on fertility outcomes and critically evaluates the past and recent literature relevant to the consumption of date fruit against infertility-related problems. Due to its antioxidant potential, dates are considered a functional treatment for reducing the risks of infertility. In males, the date palm has a potent effect on the reproductive parameters including hormonal levels and seminal vesicle parameters as well as sperm motility, count, and viability; whereas, in females, it shows a convincing effect on reproductive parameters including oogenesis process, strengthening of oocytes, regulation of hormones, strengthening of pregnancy, reduction of the need for labor augmentation, and postpartum hemorrhage prevention.

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Anti-hypercholesterolemic impacts of barley and date palm fruits on the ovary of Wistar albino rats and their offspring

Cited by 17 publications

References 112 publications

Anti-Toxoplasmaactivity of silver nanoparticles green synthesized withPhoenix dactyliferaandZiziphus spina-christiextracts which inhibits inflammation through liver regulation of cytokines in Balb/c mice

Anti-Toxoplasmaactivity of silver nanoparticles green synthesized withPhoenix dactyliferaandZiziphus spina-christiextracts which inhibits inflammation through liver regulation of cytokines in Balb/c mice

Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Therapeutic Potential of Date Palm against Human Infertility: A Review

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