Anti-hypercholesterolemic effect of a sulfur containing amino acid, S-methyl-l-cysteine sulfoxide, isolated from cabbage

Fujiwara, Motohatsu; Itokawa, Yoshinori; Uchino, Hiroshi; Inoue, Kikuko

doi:10.1007/bf01928671

Cited by 35 publications

(15 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since SMCS, a component of cabbage, was reported to reduce the serum Ch level in Ch-loaded rats (22,23), we next investigated its effect on Ch metabolism in the hepatoma-bearing rats. In this experiment, the cabbage extract and SMCS solution were administered orally, because a slight (though not significant) reduction in food intake was observed in feeding the cabbage extract-supplemented diet in experiment 1 (as seen in Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The component(s) in cabbage which has the hypocholesterolemic activity in the hepatoma-bearing state is unknown. SMCS, which was identified by Morris and Thompson (24) as a constituent of a number of species of Cruciferae plants such as cabbage, cauliflower and broccoli, was reported to suppress hypercholesterolemia in Ch-loaded rats (22,23). So, we compared the actions of SMCS with those of cabbage extract in hepatoma-bearing rats.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Suppression of hypercholesterolemia in hepatoma‐bearing rats by cabbage extract and its component, S‐methyl‐l‐cysteine sulfoxide

Komatsu

Miura

Yagasaki

1998

Lipids

View full text Add to dashboard Cite

The effect of cabbage extract on cholesterol metabolism was studied in Donryu rats subcutaneously implanted with an ascites hepatoma cell line (AH109A). The hepatoma-bearing rats exhibited hypercholesterolemia induced by increasing cholesterogenesis in the host liver and decreasing steroid excretion into feces. The cabbage extract intake or administration reduced serum cholesterol level and enhanced fecal bile acid excretion and cholesterol 7alpha-hydroxylase activity, the rate-limiting enzyme of bile acid biosynthesis, in the microsomal fraction of the liver. Furthermore, S-methyl-L-cysteine sulfoxide, a component of cabbage, could mimic the effect of cabbage extract when orally administered. These results suggest that cabbage suppresses hypercholesterolemia responding to hepatoma growth by upregulating cholesterol catabolism and that S-methyl-L-cysteine sulfoxide in cabbage is one of the factors suppressing hypercholesterolemia in the hepatoma-bearing rats.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Suppression of hypercholesterolemia in hepatoma‐bearing rats by cabbage extract and its component, S‐methyl‐l‐cysteine sulfoxide

Komatsu

Miura

Yagasaki

1998

Lipids

View full text Add to dashboard Cite

show abstract

“…Brassica vegetables are also dietary sources of S‐methylcysteine sulfoxide (SMCSO) that has been shown to reduce plasma LDL‐C levels when administered to rodents . However, the level of SMCSO in HG broccoli is approximately 20% less than in standard broccoli , and thus unlikely to explain the greater ability of the HG broccoli to reduce LDL‐C compared to standard broccoli, although may still contribute to reducing plasma LDL‐C levels by both broccoli genotypes.…”

Section: Discussionmentioning

confidence: 99%

Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials

Armah

Derdemezis

Τράκα

et al. 2015

Molecular Nutrition Food Res

View full text Add to dashboard Cite

ScopeCruciferous-rich diets have been associated with reduction in plasma LDL-cholesterol (LDL-C), which may be due to the action of isothiocyanates derived from glucosinolates that accumulate in these vegetables. This study tests the hypothesis that a diet rich in high glucoraphanin (HG) broccoli will reduce plasma LDL-C.Methods and resultsOne hundred and thirty volunteers were recruited to two independent double-blind, randomly allocated parallel dietary intervention studies, and were assigned to consume either 400 g standard broccoli or 400 g HG broccoli per week for 12 weeks. Plasma lipids were quantified before and after the intervention. In study 1 (37 volunteers), the HG broccoli diet reduced plasma LDL-C by 7.1% (95% CI: –1.8%, –12.3%, p = 0.011), whereas standard broccoli reduced LDL-C by 1.8% (95% CI +3.9%, –7.5%, ns). In study 2 (93 volunteers), the HG broccoli diet resulted in a reduction of 5.1% (95% CI: –2.1%, –8.1%, p = 0.001), whereas standard broccoli reduced LDL-C by 2.5% (95% CI: +0.8%, –5.7%, ns). When data from the two studies were combined the reduction in LDL-C by the HG broccoli was significantly greater than standard broccoli (p = 0.031).ConclusionEvidence from two independent human studies indicates that consumption of high glucoraphanin broccoli significantly reduces plasma LDL-C.

show abstract

“…Other factors affecting MCSO concentrations include environmental conditions, nutrient availability, harvest timing, and storage practices ( 25 – 27 ). While is it generally accepted that MCSO and other thermally generated breakdown products such as S -methyl methanethiosulphinate and S -methyl methanethiosulfonate, contribute to the typical flavor of processed cruciferous vegetables, their cardiovascular effect, although limited, has been reported ( 28 , 29 ).…”

Section: Brief Survey Of Organosulfides Rich Foodsmentioning

confidence: 99%

Chemical and Biochemical Mechanisms Underlying the Cardioprotective Roles of Dietary Organopolysulfides

et al. 2015

View full text Add to dashboard Cite

Foods that are rich in organosulfides are highly regarded for their broad range of functions in disease prevention and health promotion since ancient time yet modern scientific study, particularly clinical studies could not agree with traditional wisdom. One of the complexities is due to the labile nature of organosulfides, which are often transformed to different structures depending on the processing conditions. The recent evidence on polysulfides as H2S donors may open up a new avenue for establishing structure and health promotion activity relationship. To put this development into perspective, we carried out a review on the recent progress on the chemistry and biochemistry of organopolysulfides with emphasis on their cardioprotective property. First, we briefly surveyed the foods that are rich in polysulfides and their structural diversity. This is followed by in-depth discussion on the chemical transformations of polysulfides under various processing conditions. We further reviewed the potential action mechanisms of polysulfides in cardioprotection through: (a) hydrogen sulfide releasing activity; (b) radical scavenging activity; and (c) activity in enzyme inhibition and intervention of gene regulation pathways. Based on the literature trend, we can conclude that the emerging concept of organopolysulfides as naturally occurring H2S donors is intriguing and warrants further research to establish the structure and activity relationship of the organopolysulfides as H2S donors.

show abstract

Anti-hypercholesterolemic effect of a sulfur containing amino acid, S-methyl-l-cysteine sulfoxide, isolated from cabbage

Cited by 35 publications

References 7 publications

Suppression of hypercholesterolemia in hepatoma‐bearing rats by cabbage extract and its component, S‐methyl‐l‐cysteine sulfoxide

Suppression of hypercholesterolemia in hepatoma‐bearing rats by cabbage extract and its component, S‐methyl‐l‐cysteine sulfoxide

Diet rich in high glucoraphanin broccoli reduces plasma LDL cholesterol: Evidence from randomised controlled trials

Chemical and Biochemical Mechanisms Underlying the Cardioprotective Roles of Dietary Organopolysulfides

Contact Info

Product

Resources

About