Anti-human Immunodeficiency Virus-1 Protease Activity of New Lanostane-Type Triterpenoids from Ganoderma sinense

Sato, Naoto; Zhang, Qun; Ma, Cui; Hattori, Masao

doi:10.1248/cpb.57.1076

Cited by 91 publications

(53 citation statements)

References 23 publications

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“…More interestingly, this fungus also produces many oxygenated triterpenoids (especially ganoderic acids) with a wide range of biological activities. These include differential effects on the thromboxane A2-signaling pathways in human platelets [3], inhibition of eukaryotic DNA polymerases [4], cytotoxicity to several cancer cells in vitro [1,5], inhibition of tumor invasion in vitro and in vivo [1,6,7], anti-human immunodeficiency virus-1 protease activity [8], and regulation of osteoclastogenesis [9].…”

Section: Introductionmentioning

confidence: 99%

Stimulated Production of Triterpenoids of Ganoderma lucidum by an Ether Extract from the Medicinal Insect, Catharsius molossus, and Identification of the Key Stimulating Active Components

Liu

Xiao

Wang

et al. 2011

Appl Biochem Biotechnol

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The medicinal fungus Ganoderma lucidum was inoculated into the media with and without supplementation of medicinal insect extracts to screen stimulators from Chinese medicinal insects for mycelial growth and triterpenoids production in submerged fermentation. The methanol and ether extracts of the tested insects had no significant stimulatory effect on the mycelial biomass production (P > 0.05), and those of H. remigator and Mylabris phalerata markedly inhibited the mycelial growth. However, the ether extract of Catharsius molossus at a concentration of 200 mg l(-1) led to a significant increase in triterpenoids concentration from 231.7 ± 9.77 to 313.7 ± 10.6 mg l(-1) (P < 0.01). Analysis of fermentation kinetics of G. lucidum suggests that glucose concentration in the extract of C. molossus-added group decreased more quickly as compared to the control group from day 2 to day 7 of fermentation process, while the triterpenoids biosynthesis was promoted at the same culture period. However, the culture pH profile was not affected by the addition of the extract. Chemical study of the extract show that cis-9,10-methylenehexadecanoic acid (9,10-MEA) and hexadecanoic acid (especially 9,10-MEA) were the key active compounds of the extract responsible for the stimulatory effect on the triterpenoids production.

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Section: Introductionmentioning

confidence: 99%

Stimulated Production of Triterpenoids of Ganoderma lucidum by an Ether Extract from the Medicinal Insect, Catharsius molossus, and Identification of the Key Stimulating Active Components

Liu

Xiao

Wang

et al. 2011

Appl Biochem Biotechnol

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“…Colossolactone types of triterpenoids such as colossolactone V ( 10 ), colossolactone VII ( 8 ), colossolactone VIII ( 7 ), schisanlactone A ( 33 ), colossolactone G ( 5 ) and colossolactone A ( 9 ) were isolated from the chloroform extract from G. lucidium with and IC 50 value of 5–39 μ g/ml (El Dine et al 2008). Similarly in Sato et al (2009), isolated lanostane-type triterpenoids-ganoderiol F ( 22 ), ganoderic acid GS-2 ( 48 ) and 20-hydroxylucidenic acid N ( 74 ), 20(21)-dehydrolucidenic acid N ( 39 ) from CHCl 3 extract of the fruiting body of G. sinense and demonstrated the anti-HIV-1 protease activity with IC 50 values of 20–40 μ M (El Dine et al 2008; Sato et al 2009). Compounds from the CHCl 3 extract of the fruiting bodies of G. colossum , farnesyl hydroquinone, ganomycin I ( 29 ) and ganomycin B ( 28 ), competitively inhibit the active site of HIV-1 protease enzyme with IC 50 values of 7.5 and 1.0 μ g/ml, respectively (El Dine et al 2008).…”

Section: Antiviral Activities Of Compounds and Extracts From Ganodermmentioning

confidence: 63%

Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update

Basnet

Liu

et al. 2017

Mycology

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Medicinal mushroom Ganoderma sp. is considered to be a key source for the production of therapeutic agents. Our current review indicates that a limited number (<19%; 79 out of >430) of isolated compounds have been tested and known to be active against several microorganisms and parasites. In this review, we aim to summarise all the antimicrobial and anti-parasitic works on Ganoderma sp. displayed on web of science, google scholar and endnote X7 from 1932 to August 2016. We further present and discuss the structure of active compounds against microorganisms and parasites. In addition, we also discuss the possible further research to identify lead compounds from Ganoderma sp. as a novel strategy to combat the potential global emergence of bad bugs and parasites.

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“…Our phytochemical analysis of G. sinense led to the isolation and structural determination of three new triterpene-farnesyl hydroquinone conjugates (35)(36)(37) and five new highly oxygenated lanostane-type triterpenoids (38)(39)(40)(41)(42) from the fruiting body of this medicinal mushroom. The structures of the new compounds were determined from spectroscopic data and they were named ganosinensins A−C (35−37), ganoderic acid GS-1 (38) (47), ganoderiol F (48), cerevisterol, 5,6-dihydroergosterol and ergosterol peroxide were also isolated [43][44].…”

Section: Ganoderma Triterpenes and Their Derivativesmentioning

confidence: 99%

Survey of Anti-HIV and Anti-HCV Compounds from Natural Sources

2013

Can Chem Trans

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This review article describes our recent research on (from 2005 to the end of 2012) isolation and identification of natural products, their in vivo metabolites and synthesized derivatives as potential anti-viral agents. Bioactivity assays focused on the inhibition of essential viral enzymes such as HIV protease, HCV protease, and -glucosidase. Bioactive compounds were structurally classified as lignans, triterpenes, chlorogenic acid derivatives and farnesyl hydroquinones. The possible mechanisms of inhibition of a representative triterpene and a farnesyl hydroquinone on HIV-1 protease are discussed. We structurally modified some known triterpenes (betulinic, oleanolic, ursolic and glycyrrhetic acids, panaxadiol, panaxatriol) and chlorogenic acid to identify derivatives with improved inhibitory potency or improved selectivity for viral essential enzymes. Some novel structure-activity relationships (SARs) are also presented in this paper.

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Anti-human Immunodeficiency Virus-1 Protease Activity of New Lanostane-Type Triterpenoids from Ganoderma sinense

Cited by 91 publications

References 23 publications

Stimulated Production of Triterpenoids of Ganoderma lucidum by an Ether Extract from the Medicinal Insect, Catharsius molossus, and Identification of the Key Stimulating Active Components

Stimulated Production of Triterpenoids of Ganoderma lucidum by an Ether Extract from the Medicinal Insect, Catharsius molossus, and Identification of the Key Stimulating Active Components

Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update

Survey of Anti-HIV and Anti-HCV Compounds from Natural Sources

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