Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia

Choengpanya, Khuanjarat; Ratanabunyong, Siriluk; Seetaha, Supaphorn; Tabtimmai, Lueacha; Choowongkomon, Kiattawee

doi:10.1016/j.sjbs.2021.02.012

Cited by 14 publications

(8 citation statements)

References 42 publications

(57 reference statements)

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“…For IC 50 calculations, the different concentrations of focused compounds and drug standards around 10 concentrations were performed to calculate the IC 50 values as previously described (Seetaha et al, 2020;Choengpanya et al, 2021). The reaction was started by adding 2 μL of focused compounds in each concentration into 96-well black plate.…”

Section: Determination Of Ic 50mentioning

confidence: 99%

Comparison of feline and human immunodeficiency virus reverse transcriptase enzymes through chemical screening and computational analysis

Thammajong,

Aiebchun,

Boonyarattanakalin

et al. 2024

Chem Biol Drug Des

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Feline immunodeficiency virus (FIV) is a common infection found in domesticated and wild cats worldwide. Despite the wealth of therapeutic understanding of the disease in humans, considerably less information exists regarding the treatment of the disease in felines. Current treatment relies on drugs developed for the related human immunodeficiency virus (HIV) and includes compounds of the popular non‐nucleotide reverse transcriptase (NNRTI) class. This is despite FIV‐RT being only 67% similar to HIV‐1 RT at the enzyme level, increasing to 88% for the allosteric pocket targeted by NNRTIs. The goal of this project was to try to quantify how well the more extensive pharmacological knowledge available for human disease translates to felines. To this end we screened known NNRTIs and 10 diverse pyrimidine analogs identified virtually. We use this chemo‐centric probe approach to (a) assess the similarity between the two related RT targets based on the observed experimental inhibition values, (b) try to identify more potent inhibitors at FIV, and (c) gain a better appreciation of the structure–activity relationships (SAR). We found the correlation between IC50s at the two targets to be strong (r2 = 0.87) and identified compound 1 as the most potent inhibitor of FIV with IC50 of 0.030 μM ± 0.009. This compared to FIV IC50 values of 0.22 ± 0.17 μM, 0.040 ± 0.010 μM and >160 μM for known anti HIV‐1 RT drugs Efavirenz, Rilpivirine, and Nevirapine, respectively. This knowledge, along with an understanding of the structural origin that give rise to any differences could improve the way HIV drugs are repurposed for FIV.

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Section: Determination Of Ic 50mentioning

confidence: 99%

Comparison of feline and human immunodeficiency virus reverse transcriptase enzymes through chemical screening and computational analysis

Thammajong,

Aiebchun,

Boonyarattanakalin

et al. 2024

Chem Biol Drug Des

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“…Many studies reveal that several triterpenes from Ganoderma lucidum act as antiviral agents against HIV type 1 protease ( 113 ) or by boosting the immune system indirectly blocking its multiplication ( 114 ).…”

Section: Antiviral Properties Of Mushroomsmentioning

confidence: 99%

Mushrooms as future generation healthy foods

Bell

Silva

Guina³

et al. 2022

Front. Nutr.

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The potential of edible mushrooms as an unexploited treasure trove, although rarely included in known food guidelines, is highlighted. Their role in shielding people against the side effects of an unhealthy stylish diet is reviewed. Mushrooms complement the human diet with various bioactive molecules not identified or deficient in foodstuffs of plant and animal sources, being considered a functional food for the prevention of several human diseases. Mushrooms have been widely used as medicinal products for more than 2,000 years, but globally the potential field of use of wild mushrooms has been untapped. There is a broad range of edible mushrooms which remain poorly identified or even unreported which is a valuable pool as sources of bioactive compounds for biopharma utilization and new dietary supplements. Some unique elements of mushrooms and their role in preventative healthcare are emphasized, through their positive impact on the immune system. The potential of mushrooms as antiviral, anti-inflammatory, anti-neoplastic, and other health concerns is discussed. Mushrooms incorporate top sources of non-digestible oligosaccharides, and ergothioneine, which humans are unable to synthesize, the later a unique antioxidant, cytoprotective, and anti-inflammatory element, with therapeutic potential, approved by world food agencies. The prebiotic activity of mushrooms beneficially affects gut homeostasis performance and the balance of gut microbiota is enhanced. Several recent studies on neurological impact and contribution to the growth of nerve and brain cells are mentioned. Indeed, mushrooms as functional foods' nutraceuticals are presently regarded as next-generation foods, supporting health and wellness, and are promising prophylactic or therapeutic agents.

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“…Selected Agaricus subrufescens and I. obliquus extracts provided a strong anti‐human immunodeficiency virus‐1 reverse transcriptase activity in comparison with nevirapine reference. For this reason, these species could be considered as potential target viral inhibitors (Choengpanya et al ., 2021). The promising myotherapy treatment of hypobaric hypoxia condition by C. sinensis extracts was another example of the wide variety of possibilities that mushroom provides in the human medicinal field (Mishra et al ., 2021).…”

Section: Bioactive Properties From Mushroomsmentioning

confidence: 99%

Update on potential of edible mushrooms: high‐value compounds, extraction strategies and bioactive properties

López‐Hortas

Flórez‐Fernández

Torres

et al. 2022

Int J of Food Sci Tech

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The traditional and growing importance of mushrooms due to their rich composition in nutritive and bioactive compounds converts the whole feedstock and their fractions into versatile attractive ingredients for food and nutraceuticals. The processing conditions are critically relevant to selectively recover highvaluable compounds in a sustainable way. This short review, covering scientific papers published in the last 2 years, offers an updated vision of the study and applications of edible mushroom bioactive compounds, covering aspects in relation to the novelties in the cultivation, isolation, identification, characterisation of chemical and biological properties, extraction technologies and purification, as well as food applications, particularly in novel foods.

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Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia

Cited by 14 publications

References 42 publications

Comparison of feline and human immunodeficiency virus reverse transcriptase enzymes through chemical screening and computational analysis

Comparison of feline and human immunodeficiency virus reverse transcriptase enzymes through chemical screening and computational analysis

Mushrooms as future generation healthy foods

Update on potential of edible mushrooms: high‐value compounds, extraction strategies and bioactive properties

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