Anti-HIV-1 protease triterpenoids from Stauntonia obovatifoliola Hayata subsp. intermedia

In vitroantileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes fromParinari excelsa

“…The spectral data of all these compounds ( Figure 1) were in agreement with the previously published data, thereby allowing for identification of 16β-hydroxylupane-1,20(29)-dien-3-one (1) (Wei et al 2008), (3β)-3-hydroxyolean-12-en-28-oic acid (2) (Xiao-Qiang et al 2008;Geraldo et al 2008), 3β-hydroxy-olean-5,12-dien-28-oic acid (3) (Choudhary et al 2007;Zhang et al 1993), daucosterol (4) (Duarte et al 2010;Sultana et al 2010;Bayoumi et al 2010), 3-O-β-d-glucopyranosyl-stigmasta-5,11(12)-diene (5) and chlorogenic acid (6) (Kusaura et al 2010 3 OD, showed characteristic signals of two methyl groups at 1.15 ppm (3H, t, J = 7.0 Hz) and 2.57 ppm (3H, br s). Two methoxy groups were observed at 3.21 ppm (6H, br s) and one at 3.70 ppm (3H, br s).…”

Anti-human Immunodeficiency Virus-1 Protease Activity of New Lanostane-Type Triterpenoids from Ganoderma sinense

“…23,26) Briefly, 10 ml of 50 mM NaOAc buffer containing 1 mg of substrate was mixed with 2 ml of test compounds (7 ganoderma alcohols and 15 ganoderma acids) in DMSO and then 8 ml of HIV-1 protease was added to the mixture. After incubation at 37°C for 30 min, the reaction was terminated with 3 ml of 10% TFA.…”

“…Anti-HIV-1 Protease Activities of Compounds Isolated from Ganoderma Species Our previous publications addressing the development of naturally occurring anti-viral agents, 21,22) indicate that some triterpenes, such as ganoderic acid B and ganoderiol B, 9) N-(3b-hydroxyolean-12-en-28-oyl)-6-aminohexanoic acid, 15) hemiesters of ursolic acid, 23) 3-oxotirucalla-7,24-dien-21-oic acid, 24) 16b-hydroxy-2,3-secolup-20(29)-en-2,3-dioic acid, 25) colossolactone V, 26) and 2-Oacetyldryopteric acid A, 27) potently inhibit HIV-1 PR, which is an essential enzyme for HIV proliferation. 21,22) Here we compared the abilities of 11 triterpenoids isolated from the fruiting body of G. sinense and 11 [ganoderic acid A (15) …”

Endothelium-independent vasorelaxant effect of 20(S)-protopanaxadiol on isolated rat thoracic aorta

“…The beneficial effects of ginseng have been investigated in disorders of the central nervous systems, cardiovascular system, endocrine system and immune system [7,8] . Ginseng also exhibits free radicals scavenging activity and inhibitory effects on human immunodeficiency virus type (HIV) and hepatitis C virus (HCV) proteases [9,10] . To date, more than 40 ginsenosides, which are the main bioactive chemical constituents of ginseng, have been reported [11] .…”