Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma Lucidum

El‐Mekkawy, Sahar; Meselhy, Meselhy R.; Nakamura, Norio; Tezuka, Yasuhiro; Hattori, Masao; Kakiuchi, Nobuko; Shimotohno, Kunitada; Kawahata, Takuya; Otake, Toru

doi:10.1016/s0031-9422(98)00254-4

Cited by 323 publications

(173 citation statements)

References 25 publications

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“…The mycelial extracts from Lentinula produce antiprotozoal activities against Paramecium (Badalyan, 2004). Mushrooms also have antiviral properties and several compounds isolated from Ganoderma are active against H1V-1 (El- Mekkawy et al, 1998;Ichimura et al, 1998) and are also known to possess antiviral activity against influenza virus type 1. Although mushroom has numerous medicinal uses, some of the attributes of them are listed here: …”

Section: Medicinal Uses Of Mushroommentioning

confidence: 99%

Mushroom as a Mechanism to Alleviate Poverty, Unemployment and Malnutrition

Shakil¹,

Tasnia²,

Munim³

et al. 2015

Asian bus. rev.

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Mushroom is the most popular delicious, nutritious and medicinal vegetable in the world. Now it is considered as the most promising concept for crop diversification. It has been regarded as an effective means for poverty alleviation in less developed countries due to its potential for a quick, high return of profit on a small investment. Bangladesh is one of the most suitable countries in the world for Mushroom cultivation due to its favorable climate, cheap raw materials and labor cost and high market price. It is such an income generating concept that can alleviate poverty and eradicate malnutrition. It can also create employment opportunities for landless beggar, educated and uneducated youth, person with disabilities and adolescent men and women respectively. The primary objective of the study is to alleviate poverty, unemployment and malnutrition through cultivating and selling mushroom. The study is analytical and theoretical in nature and based on the secondary data. However, personal interview has been conducted to the mushroom farmers to depict the cost and profitability of Mushroom cultivation. The study finds that Mushroom cultivation can open a new opportunity for landless and unemployed people as it does not require any cultivable land and can be grown in a room by racking vertically. One can earn nearly TK 4-5 thousands a month by investing only TK 10-15 thousands. So, it is possible to make a handsome profit by investing a small amount of capital and labor in Mushroom cultivation.

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Section: Medicinal Uses Of Mushroommentioning

confidence: 99%

Mushroom as a Mechanism to Alleviate Poverty, Unemployment and Malnutrition

Shakil¹,

Tasnia²,

Munim³

et al. 2015

Asian bus. rev.

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“…Gray MD-fraction, ergosterol (1) Antioxidant (Wang et al, 1995(Wang et al, & 1996, hypotensive, Hypoglycemic (Horio et al, 2001), Immunotherapy (Hazama et al, 1995), Antiinflammatory activity (Zhang et al, 2002) Ganoderma lucidum (Curtis) P. Karst Ganoderan A and B, glucans, Triterpenes (ganoderiol F (2), ganodermanontriol (3), ganoderic acids (4) A, B, D, F, G, H, Z), ganosporeric acid A, ganopoly, the polysaccharide-containing preparation Hypoglycemic (Hikino et al, 1985), antioxidant and antitumor (Thekkuttuparambil et al, 2007), antiviral (HIV-1) (El-Mekkawy et al, 1998), Antiallergic (Kohda et al, 1985;Tasaka et al, 1988), Anti-inflammatory (Koyama et al, 1997), antihepatotoxic (Hirotani et al, 1986;Chen & Yu, 1993, inhibit the biosynthesis of cholesterol (Komoda et al, 1989), antioxidative and free radical scavenging effects (Lin, 2004) Ganoderma pfeifferi Bres. Sesquiterpenoid hydroquinones, ganodermadiol (5), lucidadiol (6) and applanoxidic acid G (7)…”

Section: Flammulina Velutipes (Curtis) Singermentioning

confidence: 99%

“…Small molecular compounds with antiviral activities, several triterpenes from Ganoderma lucidum (i.e. ganoderiol F (2), ganodermanontriol (3), ganoderic acid B (4)) are active as antiviral agents against human immunodeficiency virus type 1 (HIV-1) (El-Mekkawy et al, 1998). Ganodermadiol (5), lucidadiol (6) and applanoxidic acid G (7), isolated from G. pfeifferi, but also from other known Ganoderma species, possess in vitro antiviral activity against influenza virus type A (IC50 values in MDCK cells >0.22;0.22 and 0.19 mmol,respectively).…”

Section: Mushrooms As Antiviral Agentsmentioning

confidence: 99%

Mushrooms as therapeutic agents

Rathee¹,

Rathee²,

Rathee³

et al. 2012

Rev. bras. farmacogn.

113

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Abstract:Mushrooms have been known for their nutritional and culinary values and used as medicines and tonics by humans for ages. In modern terms, they can be considered as functional foods which can provide health benefits beyond the traditional nutrients. There are monographs that cover the medicinal and healing properties of some individual traditional mushrooms. There has been a recent upsurge of interest in mushrooms not only as a health food which is rich in protein but also as a source of biologically active compounds of medicinal value which include complementary medicine/dietary supplements for anticancer, antiviral, hepatoprotective, immunopotentiating and hypocholesterolemic agents. However the mechanisms of the various health benefits of mushrooms to humans still require intensive investigation, especially given the emergence of new evidence of their health benefits. In the present paper the medicinal potential of mushrooms is being discussed.

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“…The compounds ganoderiol F ( 22 ) and ganodermanontriol ( 23 ) were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 µ g/ml. In addition, in the same experiment ganoderiol B ( 51 ), ganoderiol A ( 21 ), ganoderic acid A ( 76 ), ganoderic acid B ( 77 ), ganoderic acid C1 ( 78 ) and ganoderic acid H ( 79 ) were found to be moderate in their efficacy (El-Mekkawy et al 1998; El Dine et al 2008). Colossolactone types of triterpenoids such as colossolactone V ( 10 ), colossolactone VII ( 8 ), colossolactone VIII ( 7 ), schisanlactone A ( 33 ), colossolactone G ( 5 ) and colossolactone A ( 9 ) were isolated from the chloroform extract from G. lucidium with and IC 50 value of 5–39 μ g/ml (El Dine et al 2008).…”

Section: Antiviral Activities Of Compounds and Extracts From Ganodermmentioning

confidence: 88%

Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update

Basnet

Liu

et al. 2017

Mycology

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Medicinal mushroom Ganoderma sp. is considered to be a key source for the production of therapeutic agents. Our current review indicates that a limited number (<19%; 79 out of >430) of isolated compounds have been tested and known to be active against several microorganisms and parasites. In this review, we aim to summarise all the antimicrobial and anti-parasitic works on Ganoderma sp. displayed on web of science, google scholar and endnote X7 from 1932 to August 2016. We further present and discuss the structure of active compounds against microorganisms and parasites. In addition, we also discuss the possible further research to identify lead compounds from Ganoderma sp. as a novel strategy to combat the potential global emergence of bad bugs and parasites.

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Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma Lucidum

Cited by 323 publications

References 25 publications

Mushroom as a Mechanism to Alleviate Poverty, Unemployment and Malnutrition

Mushroom as a Mechanism to Alleviate Poverty, Unemployment and Malnutrition

Mushrooms as therapeutic agents

Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update

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