Anti-Herpes simplex virus (HSV-1) activity and antioxidant capacity of carrageenan-rich enzymatic extracts from Solieria filiformis (Gigartinales, Rhodophyta)

Penuela, Ana; Bourgougnon, Nathalie; Bedoux, Gilles; Robledo, Daniel; Madera-Santana, Tomás; Freile‐Pelegrín, Yolanda

doi:10.1016/j.ijbiomac.2020.12.064

Cited by 33 publications

(12 citation statements)

References 79 publications

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“…Other carrageenan bioactivities, such as anti-tumor, anti-viral, and immunomodulation, have been proven and are commercially exploited [ 101 , 102 ]. In the case of herpes simplex virus types 1 and 2, HIV-1 and human rhinovirus, the carrageenan antiviral system operates by keeping virus particles far from the cell, which is considered to be an encouraging outcome [ 103 , 104 ].…”

Section: Discussionmentioning

confidence: 99%

Chondracanthus teedei var. lusitanicus: The Nutraceutical Potential of an Unexploited Marine Resource

et al. 2021

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Presently, there is a high demand for nutritionally enhanced foods, so it is a current challenge to look at new raw food sources that can supplement beneficially the human diet. The nutritional profile and key secondary metabolites of red seaweeds (Rhodophyta) are gaining interest because of this challenge. In this context, the possible use of the red seaweed Chondracanthus teedei var. lusitanicus (Gigartinales) as a novel nutraceutical source was investigated. As a result, we highlight the high mineral content of this seaweed, representing 29.35 g 100 g−1 of its dry weight (DW). Despite the low levels of calcium and phosphorus (0.26 and 0.20 g 100 g−1 DW, respectively), this seaweed is an interesting source of nitrogen and potassium (2.13 and 2.29 g−1 DW, accordingly). Furthermore, the high content of carbohydrates (56.03 g 100 g−1 DW), which acts as dietary fibers, confers a low caloric content of this raw food source. Thus, this study demonstrates that C. teedei var. lusitanicus is in fact an unexploited potential resource with the capability to provide key minerals to the human diet with promising nutraceutical properties.

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Section: Discussionmentioning

confidence: 99%

Chondracanthus teedei var. lusitanicus: The Nutraceutical Potential of an Unexploited Marine Resource

et al. 2021

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“…Sugar composition with the lowest molecular weight may have a synergist influence on the antiviral activity of carrageenan. Furthermore, carrageenan has an influence on different phases of viral infection processes based on its structural diversity and complexity (Ana et al 2021 ). Leibbrandt et al ( 2010 ) revealed that the viral infection by influenza A PR8/34 H1N1 virus in a mouse model was reduced upon exposure to treatment with iota-carrageenan nasal spray.…”

Section: Antiviral Mechanism Of Fucoidan and Carrageenanmentioning

confidence: 99%

“…Recently, carrageenan-rich enzymatic extracts from Solieria filiformis were screened for antiviral activity against HSV-1 and exhibited significant anti-HSV-1 activity at the effective concentration (EC 50 ) of 4.5 µg mL −1 without toxic effects on cells in in vitro study. These mechanisms of anti-viral activity of carrageenans are mainly related to negatively charged groups of structure that are linked to the positive charges of virus envelop and inhibit the virus attachment to the cell surface and penetration (Ana et al 2021 ). Carrageenans inhibit virus infection at different steps of the viral life, from inhibition of initial viral adsorption and entry to the host cell to blocking viral replication.…”

Section: Antiviral Mechanism Of Fucoidan and Carrageenanmentioning

confidence: 99%

Therapeutic activity of fucoidan and carrageenan as marine algal polysaccharides against viruses

2022

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Marine resources are today a renewable source of various compounds that are used in numerous industries. In recent years, considerable attention has been focused on diverse algae or their metabolites to develop several novel bioactive substances. Algae derivatives are defined as a food or part of food that has health benefits and prevention or treatment of disease. Algal sulfated polysaccharides have a high potential as a source of functional ingredients with a wide range of applications in the food and pharmaceutical industries. Fucoidan and carrageenan, as two main seaweed sulfated polysaccharides, possess numerous biological properties. These polysaccharides are highly valuable in food and healthy immune system diet and also can be applied in the pharmaceutical field. They have shown antiviral activity against SARS-CoV-2 causes COVID-19 infection by preventing virus entry into the cell or interfering with viral replication. Thus, they may provide some novel ingredients for the production of healthy functional foods, antiviral supplement formulations, or algal-based treatments for viral respiratory diseases, especially anti-COVID-19 and recommend solutions to this global health problem in the future. This article provides a review of recent researches on immune-boosting food ingredients, the antiviral activity of algae bioactive compounds, fucoidan, and carrageenan, in particular against SARS-CoV-2.

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“…When the tobacco leaves were treated with laminaran, they displayed systemic resistance and protection effect on host against the virus [164]. Table 1includes more antiviral applications of sulfated marine polysaccharides [136,[165][166][167][168][169][170][171][172][173][174][175][176][177][178]. red seaweed carrageenan in vitro and in vivo antiviral activity against Japanese encephalitis virus (JEV) [171] Ulva pertusa ulvan antiviral activity against vesicular stomatitis virus [136] Laminaria japonica fucose, galactose, and mannose in vitro inhibition of enterovirus EV71 and 3C protein activity [172] Solieria filiformis polyphenol-rich extracts antiviral activity against measles virus (MeV) [173] Gracilaria birdiae sulfated polysaccharides white spot syndrome virus (WSSV) [174] Grateloupia filicinia polysaccharides Antiviral activity towards avian leucosis virus (ALV-J) [175] Ulva intestinalis crude extract antiviral activity against white spot syndrome virus (WSSV) and yellowhead virus (YHV) [176] Monostroma nitidum rhamnan sulfate anti-influenza A virus activity [177] Macrocystis pyrifera Durvillaea antarctica extract anti-herpetic activity against HSV-1 and HSV-2 [178]…”

Section: Laminaranmentioning

confidence: 99%

Potential Antiviral Properties of Industrially Important Marine Algal Polysaccharides and Their Significance in Fighting a Future Viral Pandemic

Bai

Tuvikene

2021

Viruses

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Over the decades, the world has witnessed diverse virus associated pandemics. The significant inhibitory effects of marine sulfated polysaccharides against SARS-CoV-2 shows its therapeutic potential in future biomedical applications and drug development. Algal polysaccharides exhibited significant role in antimicrobial, antitumor, antioxidative, antiviral, anticoagulant, antihepatotoxic and immunomodulating activities. Owing to their health benefits, the sulfated polysaccharides from marine algae are a great deal of interest globally. Algal polysaccharides such as agar, alginate, carrageenans, porphyran, fucoidan, laminaran and ulvans are investigated for their nutraceutical potential at different stages of infection processes, structural diversity, complexity and mechanism of action. In this review, we focus on the recent antiviral studies of the marine algae-based polysaccharides and their potential towards antiviral medicines.

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Anti-Herpes simplex virus (HSV-1) activity and antioxidant capacity of carrageenan-rich enzymatic extracts from Solieria filiformis (Gigartinales, Rhodophyta)

Cited by 33 publications

References 79 publications

Chondracanthus teedei var. lusitanicus: The Nutraceutical Potential of an Unexploited Marine Resource

Chondracanthus teedei var. lusitanicus: The Nutraceutical Potential of an Unexploited Marine Resource

Therapeutic activity of fucoidan and carrageenan as marine algal polysaccharides against viruses

Potential Antiviral Properties of Industrially Important Marine Algal Polysaccharides and Their Significance in Fighting a Future Viral Pandemic

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