Anti-hepatocarcinoma Effects of a Food Additive Resveratrol Nanosuspension Against Human HepG2 Cells

Luo, Shi-Qiong; Lu, Wenliang; Wang, Yifei; Wang, Zhiping

doi:10.19026/ajfst.8.1493

Cited by 2 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The particle size of the nanosuspension was ~159 nm, and the zeta potential was −2.1 mV. The nanosuspension inhibited the proliferation of HepG2 cells (2.5‐fold lower IC50 values) than the bulk resveratrol 150 . Therefore, resveratrol‐loaded nanoformulations were found to be very promising for the treatment of hepatocarcinoma.…”

Section: Anticancer Activity Of Resveratrol Nanoformulationsmentioning

confidence: 99%

See 1 more Smart Citation

Resveratrol‐loaded nanomedicines for cancer applications

et al. 2021

View full text Add to dashboard Cite

Background Resveratrol (3, 5, 4′‐trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti‐inflammatory, and antioxidant properties. However, its poor water solubility, low chemical stability, and short biological half‐life limit its clinical utility. Recent findings Nanoparticles overcome the limitations associated with conventional chemotherapeutic drugs, such as limited availability of drugs to the tumor tissues, high systemic exposures, and consequent toxicity to healthy tissues. This review focuses on the physicochemical properties of resveratrol, the therapeutic potential of resveratrol nano‐formulations, and the anticancer activity of resveratrol encapsulated nanoparticles on various malignancies such as skin, breast, prostate, colon, liver, ovarian, and lung cancers (focusing on both in vitro and in vivo studies). Conclusions Nanotechnology approaches have been extensively utilized to achieve higher solubility, improved oral bioavailability, enhanced stability, and controlled release of resveratrol. The resveratrol nanoparticles have markedly enhanced its anticancer activity both in vitro and in vivo, thus considering it as a potential strategy to fight various cancers.

show abstract

Section: Anticancer Activity Of Resveratrol Nanoformulationsmentioning

confidence: 99%

“…The nanosuspension inhibited the proliferation of HepG2 cells (2.5-fold lower IC50 values) than the bulk resveratrol. 150 Therefore, resveratrol-loaded nanoformulations were found to be very promising for the treatment of hepatocarcinoma. pro-caspase-3, PI3K, Akt, and upregulation of caspase-8 and Bax.…”

Section: In Vitro Studiesmentioning

confidence: 99%