Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy

Subramanian, Aruna Priyadharshni; Jaganathan, Saravana Kumar; Manikandan, A.; Pandiaraj, K. N.; Nageswaran, Gomathi; Supriyanto, Eko

doi:10.1039/c6ra07802h

Cited by 112 publications

(43 citation statements)

References 85 publications

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“…Recently, semiconductor nanomaterials have established wide knowledge than their same bulk materials, due to their size and surface effects, which display distinctive properties such as magneto-optical, electrochemical, sensor materials, bio-medical and photo-catalytic activity [1][2][3][4][5]. Also, the use of semiconductor materials in modern applications as computer and photovoltaic production led to fully open research in the field of materials science [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The investigation of mechanical and dielectric properties of Samarium doped ZnO nanoparticles

Badreddine

Srour

Awad

et al. 2020

Mater. Res. Express

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Zn1−xSmxO nanoparticles, with 0.00 ≤ x ≤ 0.10, were prepared using chemical co-precipitation method. The structure and morphology of the obtained samples were characterized using x-ray powder diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM), respectively. However, the mechanical properties were investigated via digital Vickers microhardness tester. Vickers microhardness measurements were carried out at different applied loads, varying between 0.5 and 10 N at dwell time 60 s on pressed discs of average thickness 3 mm. Hv decreased as the Sm-content increased up to 0.02 and then it increased for higher concentrations. Whereas, it increased as the applied load increased, revealing that the samples exhibited a reverse indentation size effect (ISE). The microhardness measurements were interpreted using various models such as Meyer’s law, Hays and Kendall (HK) approach, elastic/plastic deformation (EPD), proportional specimen resistance (PSR) and the indentation-induced cracking (IIC). Mechanical parameters such as Young’s modulus (E), yield strength (Y), fracture toughness (K) and brittleness index (B) were calculated as a function of x. The most adequate model for the true microhardness of these samples is IIC. It was found that the addition of Sm content enhanced the mechanical properties of the prepared samples after x = 0.02. Dielectric measurements were used to compute different parameters such as real and imaginary parts of the complex permittivity, dielectric loss (tan δ) and ac conductivity (σ ac).

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Section: Introductionmentioning

confidence: 99%

The investigation of mechanical and dielectric properties of Samarium doped ZnO nanoparticles

Badreddine

Srour

Awad

et al. 2020

Mater. Res. Express

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“…28 In addition, TPL was proved efficient in reducing tumor growth and prolonging the living time. [29][30][31] TPL can also enhance the activities of chemotherapeutic agents in colon carcinoma cells, myeloma cell lines, and human oral cavity squamous cell carcinoma cells. [32][33][34] As reported, the combination of TPL with other anticancer drugs resulted in synergistic effects and promoted apoptosis but did not intensify the side effects of chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment

Wu¹,

Lu²,

Zhang³

et al. 2017

IJN

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Codelivery is a promising strategy to overcome the limitations of single chemotherapeutic agents in cancer treatment. Despite progress, codelivery of two or more different functional drugs to increase anticancer efficiency still remains a challenge. Here, reduction-sensitive lipid–polymer hybrid nanoparticles (LPNPs) drug delivery system composed of monomethoxy-poly(ethylene glycol)- S - S -hexadecyl (mPEG- S - S -C 16 ), soybean lecithin, and poly(D,L-lactide-co-glycolide) (PLGA) was used for codelivery of doxorubicin (DOX) and a Chinese herb extract triptolide (TPL). Hydrophobic DOX and TPL could be successfully loaded in LPNPs by self-assembly. More importantly, drug release and cellular uptake experiments demonstrated that the two drugs were reduction sensitive, released simultaneously from LPNPs, and taken up effectively by the tumor cells. DOX/TPL-coloaded LPNPs (DOX/TPL-LPNPs) exhibited a high level of synergistic activation with low combination index (CI) in vitro and in vivo. Moreover, the highest synergistic therapeutic effect was achieved at the ratio of 1:0.2 DOX/TPL. Further experiments showed that TPL enhanced the uptake of DOX by human oral cavity squamous cell carcinoma cells (KB cells). Overall, DOX/TPL-coencapsulated reduction-sensitive nanoparticles will be a promising strategy for cancer treatment.

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“…Various strategies i.e. immobilized TiO 2 , non-thermal plasma, Pt deposited TiO 2 films, TiO 2 nano fibers, bismuth degradation have been successfully employed for degradation of pharmaceuticals in wastewater [14][15][16]. The most common use of semiconductor photo catalysis is to control pollution.…”

Section: Introductionmentioning

confidence: 99%

“…With various compositions NPs have been preparedby physical and chemical methods. The physical methods may be evaporation, sputtering, laser ablation, ion ejection, and electron-beam lithography [15,16,21].…”

Section: Introductionmentioning

confidence: 99%

Microwave assisted synthesis of zinc vanadate nanoparticles and photocatalytic application

Iqbal

Fatima

Javed³

et al. 2020

Mater. Res. Express

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In recent years, the nanotechnology has gained much attention since the nanoparticles (NPs) have applications in every field of life. The hetero-structured are of special interest due to their higher photocatalytic activity. In present investigation, Zinc vanadate NPs were synthesized from vanadium and zinc salts by microwave assisted precipitation method. The Zinc vanadate NPs were characterized by x-ray Powder Diffraction (XRD), Energy-dispersive x-ray spectroscopy (EDX), Scanning electron microscope (SEM) and UV-visible techniques. The photocatalytic activity (PCA) was evaluated by degrading the methylene blue (MB) dye and process variables were optimized. The Zinc vanadate size was <100 nm and particles were in aggregates form. The MB dye degradation was performed at different conditions of process variables and it was observed that MB dye was significantly degraded using Zinc vanadate NPs under UV light irradiation. The reaction time, catalyst dose and dye initial concentration showed variable effect on dye degradation. Based on results, it can be concluded that the microwave irradiation is viable for the synthesis of Zinc vanadate NPs for photocatalytic activity. In view of promising efficiency of Zinc vanadate NPs, it can be used for the dye degradation and for the remediation of textile effluents.

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Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy

Abstract: The phytochemicals were found to become more soluble when delivered by the nanocarriers and exhibited a remarkable effect on the cancer cells compared to its free form.

Cited by 112 publications

References 85 publications

The investigation of mechanical and dielectric properties of Samarium doped ZnO nanoparticles

The investigation of mechanical and dielectric properties of Samarium doped ZnO nanoparticles

Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment

Microwave assisted synthesis of zinc vanadate nanoparticles and photocatalytic application

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Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy

Abstract: The phytochemicals were found to become more soluble when delivered by the nanocarriers and exhibited a remarkable effect on the cancer cells compared to its free form.

Cited by 112 publications

References 85 publications

The investigation of mechanical and dielectric properties of Samarium doped ZnO nanoparticles

The investigation of mechanical and dielectric properties of Samarium doped ZnO nanoparticles

Codelivery of doxorubicin and triptolide with reduction-sensitive lipid&ndash;polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment

Microwave assisted synthesis of zinc vanadate nanoparticles and photocatalytic application

Contact Info

Product

Resources

About

Codelivery of doxorubicin and triptolide with reduction-sensitive lipid–polymer hybrid nanoparticles for in vitro and in vivo synergistic cancer treatment