Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro

Wang, Guifeng; Shi, Liping; Ren, Yudan; Liu, Qun‐Fang; Liu, Houfu; Zhang, Rujun; Li, Zhuang; Zhu, Fenghua; He, Pei‐Lan; Tang, Wei; Pan, Tao; Li, Chuan; Zhao, Weimin; Zuo, Jian‐Ping

doi:10.1016/j.antiviral.2009.05.002

Cited by 353 publications

(232 citation statements)

References 30 publications

Supporting

Mentioning

211

Contrasting

Unclassified

Order By: Relevance

“…Author(s) agree that this article remains permanently open access under the terms of the Creative Commons Attribution License 4.0 International License Wang et al, 2009;Danino et al, 2009). It is feasible to utilize tobacco by-products as the material for separating chlorogenic acids.…”

Section: Abbreviations: Ca Chlorogenic Acid; Lc-ms Liquid Chromatogmentioning

confidence: 99%

Separation and purification of chlorogenic acid from tobacco by-products by polyamide and silicagel column chromatography

Zhao¹,

Chen²,

Li³

et al. 2015

Afr. J. Biotechnol.

View full text Add to dashboard Cite

Methods for separation of chlorogenic acid (CA) from tobacco by-products were established. The liquid chromatography tandem mass spectrometry (LC-MS) method for identification and analysis of chlorogenic acid from tobacco materials has been developed. CA was isolated by polyamide and further purified by silicagel column chromatography. Results reveal that polyamide is suitable for separation of CA from tobacco extract. After one run treatment with polyamide, the content of chlorogenic acids was 40.3%. The product was further purified using silicagel column chromatography; the content of total chlorogenic acid was increased 2.29-fold from 40.3 to 92.2%. The LC-MS results showed that total chlorogenic acids were made up of four components: 5-CQA, 3-CQA, 4-CQA and cis-5-CQA. The content of 5-CQA was the most (78.2%) and other three chlorogenic acid derivatives were 1.9, 10.1 and 2.0%, respectively.

show abstract

Section: Abbreviations: Ca Chlorogenic Acid; Lc-ms Liquid Chromatogmentioning

confidence: 99%

Separation and purification of chlorogenic acid from tobacco by-products by polyamide and silicagel column chromatography

Zhao¹,

Chen²,

Li³

et al. 2015

Afr. J. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…For example, R. rosea extract has shown antiviral activity against coxsackievirus B3 by preventing the virus from attaching and entering host cells [31]. R. rosea extracts also contain a number of antiviral chemicals, including gallic acid, caffeic acid, chlorogenic acid, and catechin [32], which have inhibited the replication of human rhinoviruses [33], hepatitis B virus [34], and influenza virus [16,17]. N. sativa extract has shown antimicrobial properties against Escherichia coli, Bacillus subtilis, and other bacteria [35].…”

Section: Introductionmentioning

confidence: 99%

Sambucus nigra Extracts Inhibit Infectious Bronchitis Virus at an Early Point during Replication

Chen¹,

Zuckerman²,

Brantley³

et al. 2013

Planta Med

View full text Add to dashboard Cite

Background: Infectious bronchitis virus (IBV) is a pathogenic chicken coronavirus. Currently, vaccination against IBV is only partially protective; therefore, better preventions and treatments are needed. Plants produce antimicrobial secondary compounds, which may be a source for novel anti-viral drugs. Non-cytotoxic, crude ethanol extracts of Rhodiola rosea roots, Nigella sativa seeds, and Sambucus nigra fruit were tested for anti-IBV activity, since these safe, widely used plant tissues contain polyphenol derivatives that inhibit other viruses.

show abstract

“…These bacteria have been shown to have multiple beneficial health effects including the establishment of intestinal microbiota, the promotion of mucosal barrier functions, the blockage and elimination of pathogens, the prevention of certain cancers, and the maturation of the innate and adaptive immune systems (Parvez et al, 2006). Additionally, these bacteria are being used in fermented foods in several centuries without adverse effects, and are classified as Generally Recognized as Safe (GRSA) because of their histories of safe use (Wang et al, 2009). …”

mentioning

confidence: 99%

“…However, the metabolism of toxic chemicals, drugs, and virus infections in liver results in hepatic damage, gross cellular changes, and cell death causing hepatotoxicity or liver damage (Jain et al, 2011). Hepatitis is the leading cause of acute liver failure (Wang et al, 2009), and hepatic problems are responsible for a significant numbers of liver transplantations and deaths (Samal and Dangi, 2014). Worldwide the mortality and morbidity associated with liver diseases continue to increase and nearly 20,000 deaths and 2,500,000 new cases were recorded in each year (Nallamilli et al, 2013).…”

mentioning

confidence: 99%

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Lee¹,

Park²,

Kim³

et al. 2015

The Korean Journal of Microbiology

View full text Add to dashboard Cite

Probiotics are microbial food supplements or components of bacteria which have traditionally been added to dairy foods for extra health boost. Our aim was to evaluate the hepatoprotective effect of Bifidobacterium adolescentis SPM0212 as probiotics, which we previously found has potential anti-hepatitis B virus activity. The study was conducted using Wistar albino rats and probiotics were treated orally for 9 days consecutively and acute liver injury was induced by administration of carbon tetrachloride (CCl4) on the 7th and 8th days. Liver damage was assessed by quantifying serum activities of glutamate oxaloacetate transaminase (SGOT) and glutamate pyruvate transaminase (SGPT), as well as by histopathological examination. B. adolescentis SPM0212 significantly prevented the elevation of SGOT and SGPT levels, and reduced the negative effect of CCl4 on body and organ weights. Histopathological study revealed the livers of the carbon tetrachloride treated rats showed almost complete loss of normal hepatocyte architecture, but that rats treated with B. adolescentis SPM0212 showed minimal damage and normal hepatocyte architecture. Our results suggest that B. adolescentis SPM0212 be considered useful probiotics for protecting the liver from xenobiotics and hepatitis B virus, and as well as useful as a functional food for maintaining human health.

show abstract

Anti-hepatitis B virus activity of chlorogenic acid, quinic acid and caffeic acid in vivo and in vitro

Cited by 353 publications

References 30 publications

Separation and purification of chlorogenic acid from tobacco by-products by polyamide and silicagel column chromatography

Separation and purification of chlorogenic acid from tobacco by-products by polyamide and silicagel column chromatography

Sambucus nigra Extracts Inhibit Infectious Bronchitis Virus at an Early Point during Replication

Hepatoprotective effect of Bifidobacterium adolescentis SPM0212 on carbon tetrachloride induced hepatotoxicity

Contact Info

Product

Resources

About