Anti-Helicobacter pylori Potential of Artemisinin and Its Derivatives

Goswami, Suchandra; Bhakuni, R. S.; Chinniah, Annalakshmi; Pal, Anirban; Kar, Sudip K.; Das, Priya

doi:10.1128/aac.00407-12

Cited by 46 publications

(26 citation statements)

References 41 publications

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“…A good practice in diagnosing H. pylori with antigen tests is that antibiotics should be stopped at least four weeks and anti-secretory therapy at least two weeks before testing, as these medications negatively affects the sensitivity [11]. In Mali malaria is endemic, and antimalaria drugs might have a negative effect on the sensitivity of the test, as these drugs might eradicate or decrease the presence of H. pylori [17,18]. Most of the individuals in our study have a low educational level, and it was therefore difficult to know if they had been taking any interfering medications.…”

Section: Discussionmentioning

confidence: 99%

Chemical and biological characterization of pectin-like polysaccharides from the bark of the Malian medicinal tree Cola cordifolia

Austarheim

Christensen²,

Hegna

et al. 2012

Carbohydrate Polymers

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The bark of Cola cordifolia used in Malian traditional medicine contains unusual types of polysaccharides with immunomodulating activities. We report for the first time on the structure of a polymer designated CC1P1 having the repeating structure [2→)[α-D-Gal(1→3)]α-L-Rha(1→4)α-d-GalA(1→] as determined by NMR and GC/MS. α-Linked Gal is unusual in pectins. The Mw of 135 kDa was determined by SEC-MALLS. CC1P2 (1400 kDa), another polymer, having the same backbone, but this was substituted with α-4-OMe-GlcA, α-2-OMe-Gal and α-Gal as terminal units. CC1P1 shows a high complement-fixing activity, IC₅₀ being 2.2 times lower than the positive pectin control PMII (IC₅₀ appr. 71 μg/mL) while IC₅₀ of CC1P2 is 1.8 times lower. The simple structure of CC1P1 did not activate macrophages, while CC1P2 (100 μg/mL) showed the same potency as the positive controls PMII (100 μg/mL) and LPS (500 ng/mL). No cytotoxicity was detected.

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Section: Discussionmentioning

confidence: 99%

Chemical and biological characterization of pectin-like polysaccharides from the bark of the Malian medicinal tree Cola cordifolia

Austarheim

Christensen²,

Hegna

et al. 2012

Carbohydrate Polymers

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“…In a set of eleven studies [45][46][47][48][49][50][51][52][53][54][55] determining an activity and morphological effect of plant extracts and plant-derived compounds on H. pylori, four of them reported a bacteriostatic activity [45][46][47][48] and six indicated a bactericidal effect [49][50][51][52][53][54] of the tested compounds. In one case, the use of this classification was avoided [55].…”

Section: Plant Extracts and Plant-derived Compoundsmentioning

confidence: 99%

“…The six studies indicated the bactericidal effect of the tested compounds on H. pylori [49][50][51][52][53][54]. A capacity to completely inhibit growth was only proven in half of them [49,51,52], which was achieved in a range of 18 h [49] to 72 h [51] with MICs. A relationship between the decrease in viability and number of spherical forms was particularly well illustrated in the Lee et al article [51].…”

Section: Plant Extracts and Plant-derived Compoundsmentioning

confidence: 99%

Transformation of Helicobacter pylori into Coccoid Forms as a Challenge for Research Determining Activity of Antimicrobial Substances

Krzyżek

Grande

2020

Pathogens

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Morphological variability is one of the phenotypic features related to adaptation of microorganisms to stressful environmental conditions and increased tolerance to antimicrobial substances. Helicobacter pylori, a gastric mucosal pathogen, is characterized by a high heterogeneity and an ability to transform from a spiral to a coccoid form. The presence of the coccoid form is associated with the capacity to avoid immune system detection and to promote therapeutic failures. For this reason, it seems that the investigation for new, alternative methods combating H. pylori should include research of coccoid forms of this pathogen. The current review aimed at collecting information about the activity of antibacterial substances against H. pylori in the context of the morphological variability of this bacterium. The collected data was discussed in terms of the type of substances used, applied research techniques, and interpretation of results. The review was extended by a polemic on the limitations in determining the viability of coccoid H. pylori forms. Finally, recommendations which can help in future research aiming to find new compounds with a potential to eradicate H. pylori have been formulated.

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“…A good practice in diagnosing H. pylori with antigen tests is that antibiotics should be stopped at least four weeks and anti-secretory therapy at least two weeks before testing, as these medications negatively affects the sensitivity [11]. In Mali malaria is endemic, and anti-malaria drugs might have a negative effect on the sensitivity of the test, as these drugs might eradicate or decrease the presence of H. pylori [17, 18]. Most of the individuals in our study have a low educational level, and it was therefore difficult to know if they had been taking any interfering medications.…”

Section: Discussionmentioning

confidence: 99%

Chromatographic immunoassays for Helicobacter pylori detection - are they reliable in Mali, West Africa?

Austarheim¹,

Inngjerdingen²,

Paulsen³

et al. 2013

Pan Afr Med J

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IntroductionGastrointestinal diseases are major reasons for morbidity in Mali. As Helicobacter pylori is known to play a major role in gastritis and gastric ulcer we wanted to find a simple method for detection.MethodsTwenty-nine volunteers with confirmed gastric ulcer by gastroscopy and 59 randomly selected volunteers were diagnosed by using the rapid serological test Clearview® H. Pylori. The ImmunoCard STAT!® HpSA®test was applied on stool from 65 volunteers seeking help for gastrointestinal related ailments.ResultsA Helicobacter pylori prevalence of 21% was found among the individuals with confirmed gastric ulcer, 44% among the randomly selected volunteers and 14% in individuals with gastrointestinal related ailments.ConclusionAccording to what is already known about the aetiology of gastric ailments and the prevalence of Helicobacter pylori in neighboring countries, the infection rates in our study appear strikingly low. This might indicate that Clearview® H. Pylori and ImmunoCard STAT!® HpSA® have low sensitivities in the populations studied. Strain variability of H. Pylori may be an explanation. The tests need to be properly evaluated in Mali before they can be relied upon as diagnostic tools.

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Anti-Helicobacter pylori Potential of Artemisinin and Its Derivatives

Abstract: ABSTRACTThe antimalarial drug artemisinin fromArtemisia annuademonstrated remarkably strong activity againstHelicobacter pylori, the pathogen responsible for peptic ulcer diseases. In an effort to develop a novel ant… Show more

Cited by 46 publications

References 41 publications

Chemical and biological characterization of pectin-like polysaccharides from the bark of the Malian medicinal tree Cola cordifolia

Chemical and biological characterization of pectin-like polysaccharides from the bark of the Malian medicinal tree Cola cordifolia

Transformation of Helicobacter pylori into Coccoid Forms as a Challenge for Research Determining Activity of Antimicrobial Substances

Chromatographic immunoassays for Helicobacter pylori detection - are they reliable in Mali, West Africa?

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