Anti‐HBc screening of blood donors: a comparison of nine anti‐HBc tests

Schmidt, Michael; Nübling, C. Micha; Scheiblauer, Heinrich; Chudy, M.; Walch, L A; Seifried, Erhard; Roth, W. Kurt; Hourfar, M. K.

doi:10.1111/j.1423-0410.2006.00818.x

Cited by 56 publications

(72 citation statements)

References 16 publications

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“…Month by month the prevalence varied between 2.9% to 7.2% with an average of 4.6%. Architect Anti-HBc II assay has a good performance in detecting antibodies to hepatitis B core antigen (27,28), however discrepancies and low predictive value of anti-HBc assays in countries with low HBV prevalence were previously reported (29)(30)(31)(32)(33). When the prevalence was measured based on the nationality, 9.2% (n = 130/1406) of Syrian and 3.2% (184/5608) of Lebanese were anti-HBc positive, respectively.…”

Section: Discussionmentioning

confidence: 99%

Low Prevalence of Occult Hepatitis B Infection Among Blood Donors in Beirut, Lebanon: Reconsider the Deferral Strategy of Anti-HBc Positive Blood Donors

et al. 2017

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Background: Hepatitis B virus (HBV) infection remains one of the major infectious threats to human health. Since the implementation of highly sensitive HBV nucleic acid testing, occult HBV infection (OBI) has been detected. Occult HBV infection is characterized by a positive HBV DNA test with undetectable HBsAg (Hepatits B surface antigen). The prevalence of OBI varies significantly between geographic areas, genotypes, and population depending on the sensitivity of the detection assays used.

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Section: Discussionmentioning

confidence: 99%

Low Prevalence of Occult Hepatitis B Infection Among Blood Donors in Beirut, Lebanon: Reconsider the Deferral Strategy of Anti-HBc Positive Blood Donors

et al. 2017

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“…49,50 However, if this strategy is applied in the studied population, the use of anti-HBc would result in the disposal of 36.2% of blood units, with 42.6% of them might actually be safe. The anti-HBs titers in the HBsAg-negative/anti-HBc-positive samples did not illustrate the absence of viral infection, as 65.8% of anti-HBc-/anti-HBs-positive OHB cases showed antiHBs titers of > 100 IU/L (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

High Prevalence of Hepatitis B Virus Infection in Young Adults in Ternate, Eastern Indonesia

Ie¹,

Turyadi²,

Sidarta³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The incidence of hepatitis B virus (HBV) infection has been declining thanks to the universal hepatitis B infant immunization program. Nevertheless, young adults born before the program implementation might have acquired HBV in early childhood or remain susceptible to infection. This study aimed to evaluate hepatitis B epidemiology in asymptomatic young adult population in Ternate, eastern Indonesia. Serum samples of 376 subjects (aged 17-25, mean 19.82 ± 1.69 years; male/female 138/238) were screened for HBV parameters serologically (HBV surface antigen [HBsAg]; its antibody [anti-HBs]; anti-core antigen [anti-HBc]), and molecularly (HBV DNA). HBsAg, anti-HBc, anti-HBs, and HBV DNA prevalence were 15.7%, 36.2%, 24.2%, and 27.9%, respectively, with male predominance. Of all subjects, 13.0% were HBsAg negative with detectable HBV DNA (occult hepatitis B [OHB]), and 56.4% showed negativity for all seromarkers. This population showed high hepatitis B prevalence with substantial occurrence of OHB. However, a high percentage of the population were still susceptible and at risk of HBV infection. This study emphasizes the necessity to improve prevention strategies to screen and manage HBV carriers, including the adoption of catch-up or booster vaccination targeted to young adult populations. Investigations on the roles of host-virus interactions associated with OHB and its implications are warranted.

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“…Hepatitis B virus (HBV) infection is a serious global health problem affecting two billion people worldwide, and 350 million people suffer from chronic HBV infection [1] . Despite mandatory screening for HBsAg by ELISA for over 20 years, transfusion-associated HBV (TAHBV) continues to be a major problem in India, more so in patients receiving repeated transfusions [2] .…”

Section: Introductionmentioning

confidence: 99%