Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice

Karim, Naymul; Jeenduang, Nutjaree; Tangpong, Jitbanjong

doi:10.1515/pjfns-2017-0018

Cited by 22 publications

(17 citation statements)

References 31 publications

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“…Ethanolic extract of GM showed the anti-diabetic effect against streptozotocin-induced diabetic rats by lowering high blood glucose, biochemical parameters, hepatic architectures and increased the HDL and total protein levels, compared to the control group [44]. While, in high-fat-diet-and streptozotocin-induced diabetic mice, mangosteen vinegar rind from GM, lowered the hyperglycemia, hyperlipidemia, oxidative stress marker, hepatic damage marker and improved the glycogen contents and anti-oxidant markers [45]. In similar model, isolated xanthone from GM demonstrated the nephroprotective effect by reducing the body weight, high glucose level, kidney hypertrophy, kidney damage marker and MDA level of plasma and kidney tissue [46].…”

Section: Anti-tumoral Propertiesmentioning

confidence: 87%

Biological properties in relation to health promotion effects of Garcinia mangostana (queen of fruit)

Karim

Tangpong

2018

JHR

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Purpose -For the prevention and cure of disease, patient use various types of chemical and drug agents. Along with their curative effect, almost all drugs have some destructive effects and side-effects. Due to the minimal and/or none of unwanted side-effect, recently, the use of herbal remedy as the drug of choice becomes the preference choice. The mangosteen, Garcinia mangostana, contains various types of polyphenols. It has been used as a traditional medicine from the ancient times till present days. The purpose of this paper is to investigate the biological properties of mangosteen in relation to health promotion effects. Design/methodology/approach -Several research papers from well-known database (such as PubMed, Google scholar, Scopus and Sciencedirect) were reviewed without considering publication-times to understand the biological properties of mangosteen. Findings -Mangosteen and its xanthone exerted diverse biological activities such as anti-oxidant, anti-inflammatory, anti-allergy, anti-bacteria, anti-fungal, anti-malaria, anticancer and anti-diabetes. Originality/value -Based on these studies, mangosteen is beneficial dietary supplement of overall human health.

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Section: Anti-tumoral Propertiesmentioning

confidence: 87%

Biological properties in relation to health promotion effects of Garcinia mangostana (queen of fruit)

Karim

Tangpong

2018

JHR

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“…But none of them focused on fermented extract of mangosteen rind against DN. In addition, our previous study focused the anti‐glycemic and hepatoprotective effects MVR against HFD/STZ‐induced T2D model (Karim, Jeenduang, & Tangpong, ). We also found that isolated xanthone derivatives from G. mangostana treatment to HFD/STZ‐induced T2D mice significantly reduced the elevated body weight, plasma glucose, KI (kidney damage indicator), kidney function parameters (BUN and CREA), and oxidative stress marker (plasma and kidney MDA) compared with diabetic control group (Karim et al., ).…”

Section: Discussionmentioning

confidence: 99%

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Karim

Chanudom

et al. 2019

Journal of Food Science

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Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)induced T2D nephropathy of albino mice. In vitro total phenolic content, 2,2'-azino-bis(3-ethylbenzothiazoline-6sulphonic acid) (ABTS) activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant capacity, and α-amylase inhibition activity as antidiabetic assay of MVR were performed. In vivo mice body weight, oral glucose, and maltose tolerance test, metabolic parameters (plasma glucose, insulin level, omeostasis model assessment-estimated insulin resistance), biochemical parameters (kidney hypertrophy, blood urea nitrogen, creatinine), oxidative stress parameters (malondialdehyde, superoxide dismutase, catalase) were estimated in an intervention study. Additionally, renal morphology and early apoptosis were observed following the H & E staining and TUNEL assay of the tissue frozen section. We found that the aqueous extract of MVR possesses potent in vitro antioxidative and antidiabetic activities. Animal intervention results showed that MVR 100, 200 mg/kgBW, and Glibenclamide 60 mg/kgBW treatments significantly improved (P < 0.05) the abovementioned parameters compared to the diabetic control group. Furthermore, treatments also significantly restored (P < 0.05) kidney histological alterations and reduced cellular apoptosis compared to the diabetic control group. These findings concluded that MVR treatments significantly modulated the glucose intolerance, metabolic alterations, and oxidative stress-induced pathological alterations and cellular apoptosis of diabetic kidney.Practical Application: Garcinia mangostana, a polyphenol rich natural product, is obtained from the tropical rain forest area of Southeast Asian countries and processes diverse biological activities including antioxidant, anti-proliferative, antiinflammatory, anti-carcinogenic, and so on. This research first time focuses on the nephro-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR) from the mangosteen fruit pericarp. Our study provides the efficient data to prove the beneficial effect of MVR as a dietary supplement for the prevention and management of diabetic nephropathy.

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“…Similarly, As'ari & Asnani (2017) showed that mangosteen pericarp extract was able to reduce LDL level in hypercholesterolemia male rats. Furthermore, MVR treatment reduced the levels of hepatoxic enzymes in the diabetic mice, aspartate aminotransferase and alanine aminotransferase protecting liver from further damage (Karim et al 2018). Moreover,…”

Section: Anti-diabetesmentioning

confidence: 91%

“…Several in vivo studies to measure mangosteen effectiveness in ameliorating diabetes have also been conducted (Table 2). For instance, diabetic mice supplied with mangosteen vinegar rind (MVR) containing 69% α-mangostin for one week were showing relatively lower plasma glucose, total cholesterol and low density lipoprotein (LDL) levels compared to non-treated diabetic control (Karim et al 2018). Similarly, As'ari & Asnani (2017) showed that mangosteen pericarp extract was able to reduce LDL level in hypercholesterolemia male rats.…”

Section: Anti-diabetesmentioning

confidence: 99%

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

2019

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Background. Mangosteen (Garcinia mangostana L.) fruit has unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method. In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result. Mangosteen has been vastly used in medicinal area including as anti-cancer, anti-microbial and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel and cardiovascular tissues against disorders and diseases. Conclusion. All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice

Cited by 22 publications

References 31 publications

Biological properties in relation to health promotion effects of Garcinia mangostana (queen of fruit)

Biological properties in relation to health promotion effects of Garcinia mangostana (queen of fruit)

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

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