Biological properties in relation to health promotion effects of <i>Garcinia mangostana</i> (queen of fruit)

Karim, Naymul; Tangpong, Jitbanjong

doi:10.1108/jhr-08-2018-043

Cited by 11 publications

(10 citation statements)

References 43 publications

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“…In addition, the dose of MVR 200 mg/kgBW showed similar effect to standard drug, Glibenclamide 60 mg/kgBW. Apart from this, MVR extract treatment also could be helpful for inflammation, allergy, bacteria, fungus, cancer, and other diseases as a result of rich polyphenolic compounds (Karim & Tangpong, ).…”

Section: Discussionmentioning

confidence: 99%

“…G. mangostana is obtained from the tropical rain forest area of Southeast Asian countries such as Thailand, Myanmar, Philippines, Sri Lanka, Indonesia, Malaysia. Mangosteen is famous for its dark purple/reddish color tasty fruit named as mangosteen fruit and it also defines as “queen of fruits” (Karim & Tangpong, ). Mangosteen possesses potent antioxidant, anti‐proliferative, pro‐apoptotic, anti‐inflammatory, and anti‐carcinogenic activities (Gutierrez‐Orozco & Failla, ; Karim & Tangpong, ; Phyu & Tangpong, ; Zarena & Sankar, ).…”

Section: Introductionmentioning

confidence: 99%

“…Mangosteen is famous for its dark purple/reddish color tasty fruit named as mangosteen fruit and it also defines as “queen of fruits” (Karim & Tangpong, ). Mangosteen possesses potent antioxidant, anti‐proliferative, pro‐apoptotic, anti‐inflammatory, and anti‐carcinogenic activities (Gutierrez‐Orozco & Failla, ; Karim & Tangpong, ; Phyu & Tangpong, ; Zarena & Sankar, ). A variety of bioactive compounds are present in mangosteen fruits, xanthone is one of them (Gutierrez‐Orozco & Failla, ; Karim, Chanudom, & Tangpong, ).…”

Section: Introductionmentioning

confidence: 99%

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Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Karim

Chanudom

et al. 2019

Journal of Food Science

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Type II diabetes (T2D) nephropathy, a major cause of end-stage kidney disease, progresses and develops from oxidative stress. Natural polyphenols can protect the kidney from diabetic nephropathy exerting antioxidant activities. The present approach enumerates the reno-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR, a phenolic aqueous extract) against high-fat diet (5 g/day up to five weeks)-/streptozotocin (single ip, dose 30 mg/kgBW)induced T2D nephropathy of albino mice. In vitro total phenolic content, 2,2'-azino-bis(3-ethylbenzothiazoline-6sulphonic acid) (ABTS) activity, 2,2-diphenyl-1-picrylhydrazyl (DPPH) antioxidant capacity, and α-amylase inhibition activity as antidiabetic assay of MVR were performed. In vivo mice body weight, oral glucose, and maltose tolerance test, metabolic parameters (plasma glucose, insulin level, omeostasis model assessment-estimated insulin resistance), biochemical parameters (kidney hypertrophy, blood urea nitrogen, creatinine), oxidative stress parameters (malondialdehyde, superoxide dismutase, catalase) were estimated in an intervention study. Additionally, renal morphology and early apoptosis were observed following the H & E staining and TUNEL assay of the tissue frozen section. We found that the aqueous extract of MVR possesses potent in vitro antioxidative and antidiabetic activities. Animal intervention results showed that MVR 100, 200 mg/kgBW, and Glibenclamide 60 mg/kgBW treatments significantly improved (P < 0.05) the abovementioned parameters compared to the diabetic control group. Furthermore, treatments also significantly restored (P < 0.05) kidney histological alterations and reduced cellular apoptosis compared to the diabetic control group. These findings concluded that MVR treatments significantly modulated the glucose intolerance, metabolic alterations, and oxidative stress-induced pathological alterations and cellular apoptosis of diabetic kidney.Practical Application: Garcinia mangostana, a polyphenol rich natural product, is obtained from the tropical rain forest area of Southeast Asian countries and processes diverse biological activities including antioxidant, anti-proliferative, antiinflammatory, anti-carcinogenic, and so on. This research first time focuses on the nephro-protective and anti-apoptotic effects of mangosteen vinegar rind (MVR) from the mangosteen fruit pericarp. Our study provides the efficient data to prove the beneficial effect of MVR as a dietary supplement for the prevention and management of diabetic nephropathy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Karim

Chanudom

et al. 2019

Journal of Food Science

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“…Table 1 shows the distribution of the 6720, 1680, and 286 for the training, validation, and test datasets, respectively. Clitoria Ternatea is known for antioxidant, antidiabetic, antimicrobial, antihelminthic, hepaprotective and antiasthmatic remedies [45] [46]; Ginkgo Biloba is known to treat cerebrovascular diseases, Alzheimer's disease and macroangiopathy [47]; Euphorbia Hirta known to treat mosquito-carried dengue diseases [48]; Curcuma Longa known for to be therapeutic for anti inflammatory, antihyperlipidemic, and antimicrobial applications [49]; Garcinia Mangostana used as traditional medicine to treat diseases such as diarrhea, abdominal pain, dysentery, wound-infections and chronic ulcer [50]; Allium Sativum know to treat hyperlipidemia and hypertension and prevents cancer and cardiovascular diseases [51] [52]. Figure 1 shows some sample images of the herbal plants stated.…”

Section: Simulation Analysis and Discussionmentioning

confidence: 99%

Fused Random Pooling in Convolutional Neural Network for Herbal Plants Image Classification

Reyes¹

2019

IJATCSE

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Convolutional Neural Network (CNN) faces concerns on overfitting. The CNN model learns during the training process but may not be able to classify new data correctly. Hence, the accuracy is higher in the training set than in the validation set. This occurs despite the breakthrough in CNN even if it is considered state of the art in image analysis. In this study, the fused random pooling is presented to create enhanced pooled feature maps, in that way, reducing overfitting and improving classification accuracy. The dataset utilized in this study consists of 8686 of six herbal plant images collected by actual photos and gathered publicly available online images. A comparison in terms of validation accuracy and validation loss of the average, max, mixed, and fused random pooling methods is presented. Results show that the fused random pooling achieved the highest validation accuracy of 98.21 percent and the lowest validation loss of 5.57 percent among the pooling methods used. The fused random pooling also led in terms of the performance evaluation on the precision, recall, and F1 score and attained results of 98.23 percent, 98.21 percent, and 98.21 percent, respectively. Thus, proving that applying fused random pooling is reliable in the herbal plant image classification.

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“…Mangosteen (Garcinia mangostana L., family Guttiferae) is known as "the queen of tropical fruits" because of its tasty flavor. The pericarp of mangosteen has been used traditionally by Southeast Asian for treating diarrhea, skin infection and wounds, amoebic dysentery, etc [15][16]. G. mangostana rind (GMR) contains a lot of water soluble antioxidant compounds.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant properties of capsule dosage form from mixed extracts of garcinia mangostana rind and solanum lycopersicum fruit

Azam¹,

Eden²,

Fibriana³

et al. 2021

actapharm

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Several studies showed both Garcinia mangostana L. and Solanum lycopersicum L. have shown important role as natural sources of antioxidant compounds. Hence, capsule supplement from mixed extracts of Garcinia mangostana L. and Solanum lycopersicum L. was prepared. This study aims to investigate the antioxidant properties from the capsules supplement contained with mixed extracts of Garcinia mangostana rind (GMR) and Solanum lycopersicum fruit (SLF). Antioxidant activity of capsule dosage form was measured using DPPH, ABTS, and FRAP assays. In addition, the total phenolic content and total flavonoid content of the capsules preparation were also evaluated. Total phenolic content was 0.7082 ± 0.1372 mg GAE/capsule and total flavonoid content was 11.7769 ± 3.9504 μg QE/capsule. The strong correlation observed between antioxidant capacity by ABTS method and the total phenolic contents (R 2 = 0.995, P<0.05) indicated that phenolic compounds in capsule preparation related with its antioxidant activity.

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Biological properties in relation to health promotion effects of Garcinia mangostana (queen of fruit)

Cited by 11 publications

References 43 publications

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Mangosteen Vinegar Rind from Garcinia mangostana Prevents High‐Fat Diet and Streptozotocin‐Induced Type II Diabetes Nephropathy and Apoptosis

Fused Random Pooling in Convolutional Neural Network for Herbal Plants Image Classification

Antioxidant properties of capsule dosage form from mixed extracts of garcinia mangostana rind and solanum lycopersicum fruit

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