Anti Genotoxic Effect of Mosinone-A on 7, 12-Dimethyl Benz[a] Anthracene Induced Genotoxicity in Male Golden Syrian Hamsters

Govindasamy, S.; Suresh, K.; Vijayaanand, Mariadoss Arokia; Rajalingam, Kasinathan; Sathiyapriya, J.

doi:10.1007/s12253-011-9418-3

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…[37] During the detoxifying metabolism of DMBA, GSH in conjunction with GST to detoxifies reactive intermediate species of DMBA and thereby enhancing resistance against oxidative stress. [38] Further we have been seen a depletion of GSH level has been observed in cancerous animals in response to DMBA mediated oxidative stress in experimental animals. The same lines of observation were documented in DMBA induced oral carcinogenesis.…”

Section: Discussionmentioning

confidence: 90%

Biochemical profiling and chemopreventive activity of phloretin on 7,12-dimethylbenz (A) anthracene induced oral carcinogenesis in male golden syrian hamsters

Anand¹,

Suresh²

2014

Toxicol Int

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Objectives:The present study was designed to examine the chemopreventive effects of phloretin against 7, 12-dimethylbenz (a) anthracene (DMBA) induced buccal pouch carcinogenesis in male golden Syrian hamsters in order to discover resources to improve the traditional medicine.Materials and Methods:Hamsters were divided into four groups of 10 animals each. Group I was served as an untreated control. Group II hamsters were painted with 0.5% DMBA in liquid paraffin on the left buccal pouches three times a week for 14 weeks. Group III hamsters were orally administrated with phloretin at a dose of 40 mg/kg body Weight (b.wt) on days alternate to DMBA application. Group IV hamsters were orally administrated with phloretin alone and served as the drug control. The experiment was terminated at the end of fourteenth week. The experimental animal's tumors were subjected into morphological examination and subsequently screened the pathological changes and estimate the activities of bi-products of lipid peroxidation, antioxidants enzymes and phase I and II detoxification enzyme status.Results:In DMBA alone treated hamster showed increased levels of lipid peroxidation by products, leads to decreased levels of enzymatic and non-enzymatic antioxidants status, activities of phase I and II detoxification enzyme status were altered. Normalized the neoplastic changes, decreased the levels of lipid by products, retain the antioxidants and restored the phase I and II enzymes were observed in phloretin administrated animals during DMBA induced oral carcinogenesis.Conclusion:Phloretin has possible chemopreventive role in which modulating the antioxidant and detoxification enzyme status, thereby retarding DMBA induced buccal pouch carcinogenesis.

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Section: Discussionmentioning

confidence: 90%

Biochemical profiling and chemopreventive activity of phloretin on 7,12-dimethylbenz (A) anthracene induced oral carcinogenesis in male golden syrian hamsters

Anand¹,

Suresh²

2014

Toxicol Int

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“…Micronuclei frequency is a sensitive indicator of genetic/ mutagenic damage (Balakrishnan et al, 2007;Wu et al, 2004). DMBA is a potent genotoxic agent that causes the alteration of normal bone marrow cells when administered into the animals (Sugunadevi et al, 2012) and the effect is retained even after a long period (Balakrishnan et al, 2007). A hallmark of neoplastic transformation is the accumulation of genetic lesions which can be characterized by having increased micronuclei frequency.…”

Section: Discussionmentioning

confidence: 99%

Chemopreventive action of non-steroidal anti-inflammatory drugs in 9,10-dimethylbenzanthracene induced lung carcinogenesis in BALB/C mice: Expression of COX-1, COX-2 and Nf-κB

Saini¹,

Sanyal²,

Bhatti

2018

JAB

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Non-steroidal anti-inflammatory drugs (NSAIDs) play an effective chemopreventive action against a variety of cancers. The present study aimed at targeting pro-inflammatory cyclooxygenase (COX) and NF-kB mediated inflammatory pathways in 9,10-dimethylbenzanthracene (DMBA) induced lung cancer in BALB/C mice and chemoprotective action of NSAIDs. Animals were divided into five groups and treated with NSAIDs, intratracheally, daily for a period of 18 weeks. Group 1 as control, received vehicle treatment; Group 2 received single dose of DMBA (10 mg/kg bw); Group 3, 4 and 5 besides DMBA treatment, also received Aspirin (60 mg/kg bw), Celecoxib (6.0 mg/kg bw) and Etoricoxib (0.6 mg/kg bw), respectively. DMBA induce DNA damage, apoptosis and expression of COX-1, COX-2 and NF-kB using immunofluorescence and blot analysis were done. The present study demonstrated the formation of micronuclei, over-expression of COX-2 and NF-kB in DMBA induced lung tumorigenesis and thereby suggesting a marked role of inflammation in the tumour progression. Results indicate the formation of micronuclei in DMBA group, which were significantly reduced in aspirin treated group, and totally absent in the celecoxib and etoricoxib groups. In conclusion, co-administration of etoricoxib and celecoxib has significantly reduced the inflammatory potential of the growing neoplasm in DMBA induced lung cancer in male BALB/C mice.

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Bauhinia forficata Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model

Morales-González

Anguiano‐Robledo

Madrigal-Santillán

et al. 2022

Plants

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Bauhinia forficata L. is a tree used in alternative medicine as an anti-diabetic agent, with little scientific information about its pharmacological properties. The hypoglycemic, antioxidant, and genoprotective activities of a methanolic extract of B. forficata leaves and stems combined were investigated in mice treated with streptozotocin (STZ). Secondary metabolites were determined by qualitative phytochemistry. In vitro antioxidant activity was determined by the DPPH method at four concentrations of the extract. The genoprotective activity was evaluated in 3 groups of mice: control, anthracene (10 mg/kg), and anthracene + B. forficata (500 mg/kg) and the presence of micronuclei in peripheral blood was measured for 2 weeks. To determine the hypoglycemic activity, the crude extract was prepared in a suspension and administered (500 mg/kg, i.g.) in previously diabetic mice with STZ (120 mg/kg, i.p.), measuring blood glucose levels every week as well as the animals’ body weight for six weeks. The extract showed good antioxidant activity and caused a decrease in the number of micronuclei. The diabetic mice + B. forficata presented hypoglycemic effects in the third week of treatment, perhaps due to its secondary metabolites. Therefore, B. forficata is a candidate for continued use at the ethnomedical level as an adjuvant to allopathic therapy.

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Anti Genotoxic Effect of Mosinone-A on 7, 12-Dimethyl Benz[a] Anthracene Induced Genotoxicity in Male Golden Syrian Hamsters

Cited by 3 publications

References 44 publications

Biochemical profiling and chemopreventive activity of phloretin on 7,12-dimethylbenz (A) anthracene induced oral carcinogenesis in male golden syrian hamsters

Biochemical profiling and chemopreventive activity of phloretin on 7,12-dimethylbenz (A) anthracene induced oral carcinogenesis in male golden syrian hamsters

Chemopreventive action of non-steroidal anti-inflammatory drugs in 9,10-dimethylbenzanthracene induced lung carcinogenesis in BALB/C mice: Expression of COX-1, COX-2 and Nf-κB

Bauhinia forficata Link, Antioxidant, Genoprotective, and Hypoglycemic Activity in a Murine Model

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