Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells

Chen, Ya-Yu; Tsai, Chia‐Ying; Tsai, Ming-Chu; Chen, Wen‐Kang; Hsu, Yu‐Wen; Lu, Fung‐Jou

doi:10.18240/ijo.2018.02.02

Cited by 6 publications

(8 citation statements)

References 45 publications

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“…Coculture of human amniotic mesenchymal stem cells (hAMSCs) with pterygium fibroblasts also showed the anti-EMT effect by inhibition of α-smooth muscle actin. Also, proximity with hAMSCs led to a diminution in the migratory an antifibrotic effect in pterygium (Chen et al, 2018).…”

Section: Wnt Pathway and Tgfβ Signaling In Pterygiummentioning

confidence: 94%

“…As a result, these cells acquire a migratory and invasive phenotype (Kalluri & Weinberg, ; Lamouille, Xu, & Derynck, ). EMT transition, which has a role in fibrosis and pterygium is a fibrotic lesion (Chen et al, ). Variety of transcription factors including SNAIL , twist‐related protein ( TWIST ), zinc finger E‐box binding homeobox ( ZEB ), and E47 are key regulators of EMT since they act on downregulation of epithelial‐specific genes and overexpression of genes related to mesenchymal phenotype (Nisticò, Bissell, & Radisky, ; Savagner, ).…”

Section: Introductionmentioning

confidence: 99%

“…As a result, these cells acquire a migratory and invasive phenotype (Kalluri & Weinberg, 2009;Lamouille, Xu, & Derynck, 2014). EMT transition, which has a role in fibrosis and pterygium is a fibrotic lesion (Chen et al, 2018).…”

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confidence: 99%

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Signaling roadmap to epithelial–mesenchymal transition in pterygium, TWIST1 centralized

Meshkani

Kooshan

Moghadam

et al. 2019

Journal Cellular Physiology

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Pterygium as a complex disease shares common features with other malignant cells in its onset recurrence and especially epithelial–mesenchymal transition (EMT) transition. Although using different approaches including conjunctival autografts, amniotic membrane, radiotherapy, mitomycin C (MMC) has shown promising insights in the inhibition of pterygium recurrence, it needs to be investigated in more details in molecular pathways to present adjuvant target therapy. In this study, we aimed to evaluate the expression of and then illustrate the role of signaling pathways on EMT in pterygium. Using real‐time polymerase chain reaction, the twist‐related protein 1 (TWIST1) expression was compared in primary pterygium and normal conjunctiva. This study assessed the mRNA expression, as well as the association between the clinicopathological indices and the gene expression level. The expression level of TWIST1 was overexpressed in 36% of our cohort ( n = 76). There was a significant positive correlation between recurrence with grade T, grade V and a significant negative correlation with growth activity. Our vast literature review on different signaling pathways in pterygium showed that EMT has centralization role in recurrence of this disease. Our data confirmed that EMT is important in the recurrence of pterygium samples and different signaling pathways end up activating the EMT markers. It is suggested to evaluate the environmental factors and their correlation with molecular markers to select favorable treatment for this kind of diseases.

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Section: Wnt Pathway and Tgfβ Signaling In Pterygiummentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Signaling roadmap to epithelial–mesenchymal transition in pterygium, TWIST1 centralized

Meshkani

Kooshan

Moghadam

et al. 2019

Journal Cellular Physiology

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“…Luo et al (20) reported that RA had an antiinflammatory effect on acute lung injury by decreasing the levels of pro-inflammatory molecules. Chen et al (21) showed that RA ameliorated the fibrosis of pterygium epithelial cells by decreasing type I collagen production and downregulating TGF-β1/Smad signaling.…”

Section: )mentioning

confidence: 99%

Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

et al. 2021

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We compared the effects of rosmarinic acid and dexpanthenol in a rat experimental wound model. Twenty-four Wistar albino rats weighing 200-250 g were randomly divided into 3 groups. After 2-cm full-thickness skin defects were created, the wounds were washed with sterile 0.9% NaCl solution. After washing, the control group was left untreated, the second group received 5% dexpanthenol cream, and the third group received 10% rosmarinic acid cream. Before excision, the skin was evaluated macroscopically by measuring the reduction in wound size; after excision, histological examination (epithelization, inflammation, fibrosis, granulation) was performed. Macroscopic comparison of the wound sizes showed that group 3 showed a statistically significant difference in wound size reduction compared to the other two groups. Histopathological examination showed that there was no statistically significant difference between the groups. We found that the rosmarinic acid group had greater wound size reduction than the other two groups. However, epithelialization was detected in fewer cases. We believe that rosmarinic acid can be used as a topical cream for wound healing, as it leads to significant reduction in wound size, resulting in fewer scars.

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“…Up to now, surgery was the main treatment for pterygium [ 16 ]. Fibrosis causes adherence of the conjunctiva and Tenon's capsule, which may lead to recurrence, and it is dependent on the patient's inflammatory response [ 17 ]. The recurrence rate of simple excision results in high recurrence from 24% to 89%.…”

Section: Discussionmentioning

confidence: 99%

Ologen Implantation versus Conjunctival Autograft Transplantation for Treatment of Pterygium

Chen

Yuan

2018

Journal of Ophthalmology

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Purpose To evaluate the effectiveness and safety of Ologen implantation versus conjunctival autograft transplantation for primary pterygium. Methods A retrospective case-series analysis. Thirty-one eyes of 29 patients were included in the Ologen group and 42 eyes of 35 patients in the autograft group. The patients were followed up for 1 year and evaluated for slit-lamp biomicroscopy, intraocular pressure, and adverse events. Recurrence rate, complications, and final appearance of the cases were evaluated prospectively. Result At 1 year after operation, 2 eyes recurred (6.5%) in the Ologen group and 4 eyes recurred (9.52%) in the autograft group. There was no statistically significant difference between both groups (P=0.157, χ2 = 3.781). There was no occurrence of serious complications. Two eyes among the 31 eyes of the Ologen group were conjunctivitis; the incidence of complications was 6.45% (2 eyes). There was conjunctivitis in 3 eyes of the autograft group, 1 eye complicated with symblepharon, and 1 eye with conjunctival granuloma; the incidence of complications was 11.90% (5 eyes), and there was no statistically significant difference between both groups (P=0.094). The conjuntiva was less vascular and inflamed at 1 month postoperatively in the Ologen group than in the autograft group. Conclusions Ologen transplantation was technically easier, provided short operative time compared with conjunctival autograft transplantation, and preserved healthy conjunctiva with less complication and less recurrence; it may be a new, safe, and effective alternative for improving the short-term success rate of primary surgery.

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Anti-fibrotic effect of rosmarinic acid on inhibition of pterygium epithelial cells

Abstract: This study demonstrate that RA could inhibit fibrosis of PECs by down-regulating type I collagen expression and TGF-β1/Smad signaling. Therefore, RA is a potent therapeutic agent for the treatment of pterygium.

Cited by 6 publications

References 45 publications

Signaling roadmap to epithelial–mesenchymal transition in pterygium, TWIST1 centralized

Signaling roadmap to epithelial–mesenchymal transition in pterygium, TWIST1 centralized

Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

Ologen Implantation versus Conjunctival Autograft Transplantation for Treatment of Pterygium

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