Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

Kuba, Mutsuo; Türkoğlu, Ahmet; Oğuz, Abdullah; Tuncer, Mehmet Cudi; Kaya, Salih Tunç; Başol, Ömer; Bilge, H; Tatlı, Faruk

doi:10.5603/fm.a2020.0097

Cited by 16 publications

(9 citation statements)

References 17 publications

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“…Our results suggest that in a complex mixture of compounds, such as an EO, some compounds might antagonize the effect of carvacrol, thus decreasing its pro-migratory properties. Similar effects were reported for rosmarinic acid, promoting cell migration in wound models [148,149] and presenting an inhibitory effect in cancer cells [150][151][152][153][154]. Salvianolic acids A and B are known to induce [155][156][157][158][159] as well as to delay [160][161][162] cell migration.…”

Section: Discussionsupporting

confidence: 66%

Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration

et al. 2023

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Aromatic plants are reported to display pharmacological properties, including anti-aging. This work aims to disclose the anti-aging effect of the essential oil (EO) of Thymbra capitata (L.) Cav., an aromatic and medicinal plant widely used as a spice, as well as of the hydrodistillation residual water (HRW), a discarded by-product of EO hydrodistillation. The phytochemical characterization of EO and HRW was assessed by GC-MS and HPLC-PDA-ESI-MSn, respectively. The DPPH, ABTS, and FRAP assays were used to disclose the antioxidant properties. The anti-inflammatory potential was evaluated using lipopolysaccharide-stimulated macrophages by assessing NO production, iNOS, and pro-IL-1β protein levels. Cell migration was evaluated using the scratch wound assay, and the etoposide-induced senescence was used to assess the modulation of senescence. The EO is mainly characterized by carvacrol, while the HRW is predominantly characterized by rosmarinic acid. The HRW exerts a stronger antioxidant effect in the DPPH and FRAP assays, whereas the EO was the most active sample in the ABTS assay. Both extracts reduce NO, iNOS, and pro-IL-1β. The EO has no effect on cell migration and presents anti-senescence effects. In opposition, HRW reduces cell migration and induces cellular senescence. Overall, our study highlights interesting pharmacological properties for both extracts, EO being of interest as an anti-aging ingredient and HRW relevant in cancer therapy.

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Section: Discussionsupporting

confidence: 66%

Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration

et al. 2023

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“…As in this experiment, the full therapeutic effect was observed on the 14th day of treatment. The data obtained is also consistent with the results of the group of researchers (Küba et al, 2021). During an experimental assessment of dexpanthenol (5% ointment) efficacy on rats, the greatest reduction in wound size in the late postoperative phase was noted: from day 10 to day 14.…”

Section: Table 7 Dynamics Of Changes In the Area Of Wound Surfaces (M...supporting

confidence: 89%

Treatment of pets with the active substance dexpanthenol in wound processes

Paliy¹,

Pavlichenko²,

Родіонова³

et al. 2023

Scientific Horizons

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Animal skin is a complex organ that directly perceives the influence of the external environment and performs a barrier-protective function, helps maintain the balance of the internal environment of the body. Disruption of each of the levels of the protective system leads to the development of inflammatory skin diseases. Treatment of wounds remains one of the most pressing scientific and practical problems of modern veterinary medicine. A number of researchers are searching for and developing new veterinary drugs for the treatment of wounds of various etiologies in small pets, but the use of drugs often causes adverse skin reactions. The purpose of this study was to evaluate the effectiveness of using a veterinary drug (ointment) in the treatment of wounds in domestic animals (dogs, cats, rabbits). The paper uses standard clinical, haematological, and biochemical research methods. The studies used a drug with the active substance dexpanthenol and excipients decamethoxine, Vaseline oil, emulsifier, glycerin, methylparaben, propylparaben, and purified water. The drug under study effectively reduced the wound surface area at all observation periods. It is proved that when using dexpanthenol-based ointment (10%), a complete wound-healing effect was observed in experimental animals on the 14th day of treatment: the area of wound surfaces decreased by 93.1±1.51%. The examined indicators were statistically substantially different from those in the group of untreated animals with skin wounds. The general clinical condition of domestic animals was examined, haematological and biochemical studies of animal blood were conducted under the conditions of applying an experimental drug to damaged skin areas. In animals with skin damage without treatment, the dynamic development of an acute inflammatory process in the body, the development of endogenous intoxication syndrome, signs of wound infection, pronounced exudation and slowing of contraction were observed. The developed veterinary drug with the active substance dexpanthenol simultaneously shows a pronounced antiinflammatory and wound-healing effect and provides a rapid therapeutic effect in wound processes in small pets

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“…Regarding isolated compounds, several studies have reported their wound healing capacities. Indeed, wound healing properties have been reported for rosmarinic acid [ 67 , 68 ], salvianolic acid A, and danshensu [ 69 , 70 , 71 , 72 ]. The aglycone apigenin also promotes in vitro and in vivo wound healing [ 73 , 74 , 75 , 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Traditional Uses of Thymbra capitata Infusion in Algarve (Portugal): Anti-Inflammatory, Wound Healing, and Anti-Aging

Alves-Silva,

Pedreiro,

Cruz

et al. 2023

Pharmaceuticals

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Inflammation plays a pivotal role in the resolution of infection or tissue damage. In addition, inflammation is considered a hallmark of aging, which in turn compromises wound healing. Thymbra capitata is an aromatic plant, whose infusion is traditionally used as an anti-inflammatory and wound-healing agent. In this study, a T. capitata infusion was prepared and characterized by HPLC-PDA-ESI-MSn and its safety profile determined by the resazurin metabolic assay. The anti-inflammatory potential was revealed in lipopolysaccharide (LPS)-stimulated macrophages by assessing nitric oxide (NO) release and levels of inducible nitric oxide synthase (iNOS) and the interleukin-1β pro-form (pro-IL-1β). Wound-healing capacity was determined using the scratch assay. The activity of senescence-associated β-galactosidase was used to unveil the anti-senescent potential, along with the nuclear accumulation of yH2AX and p21 levels. The antiradical potential was assessed by DPPH and ABTS scavenging assays. The infusion contains predominantly rosmarinic acid and salvianolic acids. The extract decreased NO, iNOS, and pro-IL-1β levels. Interestingly, the extract promoted wound healing and decreased β-galactosidase activity, as well as yH2AX and p21 levels. The present work highlights strong antiradical, anti-inflammatory, and wound healing capacities, corroborating the traditional uses ascribed to this plant. We have described, for the first time for this extract, anti-senescent properties.

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Comparison of local rosmarinic acid and topical dexpanthenol applications on wound healing in a rat experimental wound model

Cited by 16 publications

References 17 publications

Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration

Effect of Thymbra capitata (L.) Cav. on Inflammation, Senescence and Cell Migration

Treatment of pets with the active substance dexpanthenol in wound processes

Exploring the Traditional Uses of Thymbra capitata Infusion in Algarve (Portugal): Anti-Inflammatory, Wound Healing, and Anti-Aging

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