Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-β/AKT/mTOR signaling pathway

Xiao, Yang; Zhang, Tongtong; Qin, Caicheng; Wei, Peng; Luo, Li; Luo, Linzi; Huang, Guojun; Chen, Anji; Liu, Guangnan

doi:10.1016/j.lfs.2020.117552

Cited by 43 publications

(28 citation statements)

References 64 publications

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“…However, given the lack of apparent senescence in the HFD heart, this was likely independent of senolytic effects and might have been by direct attenuation of fibrosis in the heart. For instance, Q inhibits rabbit tracheal stenosis by 4 Oxidative Medicine and Cellular Longevity antifibrogenic activity and blunts isoproterenol-induced cardiac ischemia and fibrosis by scavenging reactive oxygen species and suppressing inflammation [29,30]. In this study, Q upregulated p16 and p53 myocardial gene expressions in HFD.…”

Section: Discussionmentioning

confidence: 50%

Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High‐Fat Diet: Role of Angiogenesis

Kim

Jiang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Global consumption of high-fat diets (HFD) is associated with an increased incidence of cardiometabolic syndrome and cardiac injury, warranting identification of cardioprotective strategies. Cardioprotective effects of quercetin (Q) have mostly been evaluated in ischemic heart disease models and attributed to senolysis. We hypothesized that Q could alleviate murine cardiac damage caused by HFD by restoring the myocardial microcirculation. C57BL/6J mice were fed standard chow or HFD for 6 months and then treated with Q (50 mg/kg) or vehicle 5-day biweekly for 10 additional weeks. Left ventricular (LV) cardiac function was studied in vivo using magnetic resonance imaging, and intramyocardial fat deposition, microvascular density, oxidative stress, and senescence were analyzed ex vivo. Additionally, direct angiogenic effects of Q were studied in vitro in HUVECs. HFD increased body weight, heart weight, total cholesterol, and triglyceride levels, whereas Q normalized heart weight and triglycerides. LV ejection fraction was lower in HFD vs. control mice ( 56.20 ± 15.8 % vs. 73.38 ± 5.04 % , respectively, P < 0.05 ), but improved in HFD + Q mice ( 67.42 ± 7.50 % , P < 0.05 , vs. HFD). Q also prevented cardiac fat accumulation and reduced HFD-induced cardiac fibrosis, cardiomyocyte hypertrophy, oxidative stress, and vascular rarefaction. Cardiac senescence was not observed in any group. In vitro, ox-LDL reduced HUVEC tube formation activity, which Q effectively improved. Quercetin may directly induce angiogenesis and decrease myocardial oxidative stress, which might account for its cardioprotective effects in the murine HFD-fed murine heart independently from senolytic activity. Furthermore, its beneficial effects might be partly attributed to a decrease in plasma triglycerides and intramyocardial fat deposition.

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Section: Discussionmentioning

confidence: 50%

Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High‐Fat Diet: Role of Angiogenesis

Kim

Jiang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…In another recent study, quercetin presents with anti-fibrotic activity via influence on TGF-β/Akt/mTOR signaling pathway. In addition, it reduced IL-6, VEGF, and expression of different collagen types [157]. For UFs, in 2020 Cavalcante et al found that quercetin showed uterine anti-aging features via PI3K/Akt/mTOR signaling pathway.…”

Section: Quercetinmentioning

confidence: 99%

The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids

Ciebiera

Ali

Prince

et al. 2020

JCM

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Uterine fibroids (UFs) remain a significant health issue for many women, with a disproportionate impact on women of color, likely due to both genetic and environmental factors. The prevalence of UFs is estimated to be approximately 70% depending on population. UF-derived clinical symptoms include pelvic pain, excessive uterine bleeding, gastrointestinal and voiding problems, as well as impaired fertility. Nowadays numerous methods of UF treatment are available—from conservative treatment to invasive surgeries. Selecting an appropriate treatment option should be individualized and adjusted to the patient's expectations as much as possible. So far, the mainstay of treatment is surgery, but their negative impact of future fertility is clear. On the other hand, emerging new pharmaceutical options have significant adverse effects like liver function impairment, hot flashes, bone density loss, endometrial changes, and inability to attempt conception during treatment. Several natural compounds are found to help treat UFs and relieve their symptoms. In this review we summarize all the current available data about natural compounds that may be beneficial for patients with UFs, especially those who want to preserve their future fertility or have treatment while actively pursuing conception. Vitamin D, epigallocatechin gallate, berberine, curcumin, and others are being used as alternative UF treatments. Moreover, we propose the concept of using combined therapies of natural compounds on their own or combined with hormonal agents to manage UFs. There is a strong need for more human clinical trials involving these compounds before promoting widespread usage.

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“…These challenges in diagnosing and monitoring the stenosis status have created an urgent need for reliable biomarkers to predict the progression of PTTS (20,21). The exact pathogenesis of PTTS has remained to be fully elucidated; one possible underlying mechanism involves diffuse fibrosis in the trachea and bronchus (6,(22)(23)(24)(25). Molecular changes usually require less time to manifest than morphological changes.…”

Section: Clinical Significance Of Serum Transforming Growth Factor-β1mentioning

confidence: 99%

Clinical significance of serum transforming growth factor‑β1 and procollagen type I N‑propeptide in post‑tuberculosis tracheobronchial stenosis

Bai

et al. 2021

Exp Ther Med

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Non-invasive strategies for monitoring posttuberculosis (TB) tracheobronchial stenosis (PTTS) are clinically important but currently lacking. Transforming growth factor-β1 (TGF-β1) and procollagen type I N-propeptide (PINP) have been identified as markers of fibrosis. The present study aimed to investigate the clinical significance of serum TGF-β1 and PINP in PTTS. Serum samples were collected from 119 patients with tracheobronchial TB after the condition was treated for at least 6 months (59 patients with airway stenosis and 60 patients with no stenosis). Serum TGF-β1 and PINP levels were measured using ELISA and compared between the groups. Relationships between serum TGF-β1 and PINP levels and clinical characteristics, interventional bronchoscopy and outcomes of airway stenosis were analysed. The correlation between TGF-β1 and PINP, and their diagnostic efficacy for airway stenosis were also analysed. The TGF-β1 and PINP levels in the airway stenosis group were higher than those in the non-stenosis group. Furthermore, airway stenosis with atelectasis or mucus plugging was associated with higher TGF-β1 levels, and airway stenosis with atelectasis, mucus plugging, right main bronchus stenosis or severe airway tracheal stenosis was associated with higher PINP levels. In addition, TGF-β1 and PINP levels increased after interventional bronchoscopy therapy and airway stenosis with recurrent stenosis was associated with higher baseline levels of both markers. Finally, TGF-β1 levels were positively correlated with PINP levels in patients with airway stenosis. The area under the receiver operating characteristic curve of TGF-β1 and PINP for distinguishing airway stenosis from non-stenosis cases was 0.824 (95% CI: 0.748-0.900) and 0.863 (95% CI: 0.796-0.930), respectively. Therefore, TGF-β1 and PINP are potential biomarkers that may be useful for diagnosing and monitoring PTTS.

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Anti-fibrosis activity of quercetin attenuates rabbit tracheal stenosis via the TGF-β/AKT/mTOR signaling pathway

Cited by 43 publications

References 64 publications

Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High‐Fat Diet: Role of Angiogenesis

Quercetin Reverses Cardiac Systolic Dysfunction in Mice Fed with a High‐Fat Diet: Role of Angiogenesis

The Evolving Role of Natural Compounds in the Medical Treatment of Uterine Fibroids

Clinical significance of serum transforming growth factor‑β1 and procollagen type I N‑propeptide in post‑tuberculosis tracheobronchial stenosis

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