Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice

Dong-zhou, Kang; Hong, Hee‐Do; Kim, Kyung-Im; Choi, Sang Yoon

doi:10.3746/pnf.2015.20.1.38

Cited by 27 publications

(24 citation statements)

References 20 publications

(18 reference statements)

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“…In the MS 2 spectrum, it produced a base peak at m/z 285 [M − Rha(146) − H] − . It was identified as kaempferol‐7 ‐O‐α ‐ l ‐rhamnoside according to the published literature (Kang, Hong, Kim, & Choi, ).…”

Section: Resultsmentioning

confidence: 99%

Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole time‐of‐flight mass spectrometry

Liu

Chen

Qiu³

et al. 2018

Biomedical Chromatography

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Hongjingtian injection is made from Rhodiola wallichiana and used in the treatment of stable angina pectoris associated with coronary heart disease. In this study, the chemical constituents in Hongjingtian injection were comprehensively studied using liquid chromatography quadrupole time-of-flight mass spectrometry. A total of 49 compounds were identified or assumed, including 10 organic acids, nine phenylethanoids, 10 phenylpropanoids, two flavonoid glycosides, seven monoterpene glycosides, seven octylglycosides and four other types of compounds. The structures of seven compounds were confirmed by comparing their retention times, MS and UV spectra with the corresponding authentic standards. Amongst the 49 compounds, 35 were firstly found in R. wallichiana, while they have been reported in other species of the genus Rhodiola, including Rhodiola crenulata, Rhodiola sacra, Rhodiola rosea and Rhodiola kirilowii. The possible fragmentation pathways in the mass spectrometry of the major types of compounds are proposed and summarized. Our study demonstrates a rapid method for characterizing the chemical constituents present in the Hongjingtian injection, which could also be applied to the identification of chemical constituents in other TCM formulae containing R. wallichiana.

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Section: Resultsmentioning

confidence: 99%

Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole time‐of‐flight mass spectrometry

Liu

Chen

Qiu³

et al. 2018

Biomedical Chromatography

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“…Behavior tests are commonly applied to evaluate the antifatigue performance of drugs [ 26 , 27 ]; therefore, weight-loaded swimming, rotating rod, and forced running test were taken in the present experiment. Compared to nontreated mice, both TM and ABM have significantly enhanced the exercise endurance indicated by the longer movement duration in all three behavior tests ( P < 0.05, Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Antifatigue Activity of Liquid CulturedTricholoma matsutakeMycelium Partially via Regulation of Antioxidant Pathway in Mouse

Wang

Cai

et al. 2015

BioMed Research International

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Tricholoma matsutake has been popular as food and biopharmaceutical materials in Asian countries for its various pharmacological activities. The present study aims to analyze the antifatigue effects on enhancing exercise performance of Tricholoma matsutake fruit body (ABM) and liquid cultured mycelia (TM) in mouse model. Two-week Tricholoma matsutake treatment significantly enhances the exercise performance in weight-loaded swimming, rotating rod, and forced running test. In TM- and ABM-treated mice, some factors were observed at 60 min after swimming compared with nontreated mice, such as the increased levels of adenosine triphosphate (ATP), antioxidative enzymes, and glycogen and the reduced levels of malondialdehyde and reactive oxygen species in muscle, liver, and/or serum. Further data obtained from western blot show that CM and ABM have strongly enhanced the activation of 5′-AMP-activated protein kinase (AMPK), and the expressions of peroxisome proliferator have activated receptor γ coactivator-1α (PGC-1α) and phosphofructokinase-1 (PFK-1) in liver. Our data suggest that both Tricholoma matsutake fruit body and liquid cultured mycelia possess antifatigue effects related to AMPK-linked antioxidative pathway. The information uncovered in our study may serve as a valuable resource for further identification and provide experimental evidence for clinical trials of Tricholoma matsutake as an effective agent against fatigue related diseases.

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“…132 Fermented R. rosea extract has also been found to significantly increase swimming time, hepatic superoxide dismutase content, and serum lactate dehydrogenase in mice. 133 …”

Section: Potential Treatment For Muscle Fatiguementioning

confidence: 99%

Muscle fatigue: general understanding and treatment

et al. 2017

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Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be defined as exercise-induced decrease in the ability to produce force. Here, to provide a general understanding and describe potential therapies for muscle fatigue, we summarize studies on muscle fatigue, including topics such as the sequence of events observed during force production, in vivo fatigue-site evaluation techniques, diagnostic markers and non-specific but effective treatments.

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Anti-Fatigue Effects of Fermented Rhodiola rosea Extract in Mice

Cited by 27 publications

References 20 publications

Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole time‐of‐flight mass spectrometry

Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole time‐of‐flight mass spectrometry

Antifatigue Activity of Liquid CulturedTricholoma matsutakeMycelium Partially via Regulation of Antioxidant Pathway in Mouse

Muscle fatigue: general understanding and treatment

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