Anti-fatigue activity of polysaccharide fractions from Lepidium meyenii Walp. (maca)

Li, Jing; Sun, Qingjie; Meng, Qingran; Wang, Lei; Xiong, Wentao; Zhang, Lianfu

doi:10.1016/j.ijbiomac.2016.11.031

Cited by 79 publications

(52 citation statements)

References 25 publications

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“…Several classes of secondary metabolites have been isolated from dried maca tubers, including alkaloids, glucosinolates, aromatic isothiocyanates and macamides . To the best of our knowledge, previous studies related to the anti‐fatigue effect of maca mainly concentrated on maca polysaccharides . Compared to biological macromolecules with complex structures, small‐molecule substances also play an important role in many aspects.…”

Section: Introductionmentioning

confidence: 99%

“…14 To the best of our knowledge, previous studies related to the anti-fatigue effect of maca mainly concentrated on maca polysaccharides. [15][16][17] Compared to biological macromolecules with complex structures, small-molecule substances also play an important role in many aspects. Recently, another main component and bioactive ingredient in maca, macamides, a class of benzylated or 3-methoxylbenzylated alkamides, has increasingly gained attention.…”

Section: Introductionmentioning

confidence: 99%

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Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice

Zheng

Zhang

et al. 2018

J Sci Food Agric

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice

Zheng

Zhang

et al. 2018

J Sci Food Agric

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“…The differences can be attributed to the origin of the studied Maca. Due to the diversity in composition and structure, LMP exhibited comprehensive bioactivities including anti‐fatigue (Li et al, ), antioxidant (Campos et al, ), endurance enhancement (Choi et al, ), anti‐tumor (Stojanovska et al, ), increase in sexual activity (Avelar, Orihuela, Vazquez, & Palma‐Irizarry, ), and so on.…”

Section: Discussionmentioning

confidence: 99%

“…Many works have presented details of the compositions, structures, and biological activities of the LMP (Zang et al, ). It was found that the polysaccharide was mainly composed of glucose, arabinose, galactose, and mannose (Zhang, Wu, et al, , Li et al, ). The LMP potentially plays the role in both immunity enhancement and antitumor function.…”

Section: Introductionmentioning

confidence: 99%

Optimization of Maca polysaccharide extraction process and its chemo‐protective effects on cyclophosphamide‐induced mice

Wang

Huang

et al. 2018

J Food Process Engineering

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In this study, the extraction process of Maca polysaccharide (LMP) was deeply studied and its chemo‐protective effects on Cyclophosphamide (Cy)‐induced mice were evaluated. By single factor investigation and response surface methodology optimization, it was found that the liquid‐to‐solid ratio, extraction time, and extraction temperature were the main factors which affected the extraction yield of LMP. The optimum extraction process was obtained by Box–Behnken design combined with response surface methodology. It was found that, at the condition of liquid‐to‐solid ratio of 30:1; extraction time of 2.3 hr; and extraction temperature of 90°C, the yield of the LMP could reach 46.56%. Furthermore, by oral administration of LMP, the cyclophosphamide‐induced mice showed the proliferation of lymphocyte and the phagocytic capacity of macrophages’ enhancements. The number of white blood cell, red blood cell, and platelets in the peripheral blood were up‐regulated; the spleen total superoxide dismutase, Catalase, and Glutathione‐peroxidase activities were enhanced, while the Serum malondialdehyde and Triacylglycerols content was reduced. Therefore, our work provided an effective way for extraction of LMP and demonstrated the chemo‐protective effects of LMP on the animal level. Practical application Natural polysaccharides from functional food sources are widely accepted for their bioactive activities. As extraction conditions significantly affected the quality and yield of polysaccharides, the effective extraction process for polysaccharides should be systematically investigated. In the current work, the optimum conditions for polysaccharides extraction from Maca (Lepidium meyenii Walp.) (LMP) were obtained using liquid‐to‐solid ratio of 30:1 for 2.3 hr at 90°C. The Mass characterization and Monosaccharide Composition of LMP were also determined. Furthermore, the extracted LMP exhibited well Chemo‐protective activities on Cyclophosphamide‐induced mice. Therefore, our work showed the potential applications of Maca polysaccharides as the easily accessible source of natural immunopotentiating agents in function food and pharmaceutical industry.

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“…It has been consumed as a food by local inhabitants of the Peruvian central Andes due to the nutritional and medicinal properties of its hypocotyls (Valerio & Gonzales, ). Previous studies have revealed that Maca has many pharmacological properties including improving semen quality (Lee, Lee, You, & Ha, ), possessing hepatoprotective activity against alcoholic hepatic injury (L. Zhang, Zhao, Wang, Zhao, & Zhao, ), and exhibiting dose‐dependent positive effects on fatigue‐related parameters (Li et al, ). Maca alkaloids, steroids, glucosinolates, isothiocyanates, and macamides are probably responsible for its ability to act as a fertility enhancer, aphrodisiac, adaptogen, immunostimulant, and anabolic and to influence hormonal balance (Valentová & Ulrichová, ).…”

Section: Introductionmentioning

confidence: 99%

N‐(3‐methoxybenzyl)‐(9Z,12Z,15Z)‐octadecatrienamide promotes bone formation via the canonical Wnt/β‐catenin signaling pathway

Wang

Sun

Zhong

et al. 2019

Phytotherapy Research

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Osteoporosis is characterized by low bone mineral density and microarchitectural deterioration of bone tissue. N-(3-methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (MBOC) is one of the macamides isolated from Maca (Lepidium meyenii Walp.), a cruciferous plant from the Andes of Peru. In this study, C3H/10T1/2 mesenchymal stem cells were treated with MBOC in osteogenic induction medium. An ovariectomized (OVX) mouse model was used to investigate the effect of 1-month MBOC treatment on the prevention of postmenopausal osteoporosis. Remarkably, trabecular thickness, trabecular number, and bone volume/tissue volume of the distal femoral metaphysis were significantly increased in OVX + MBOC mice compared with OVX mice, as revealed by microcomputed tomography analysis. Trabecular separation was decreased in OVX + MBOC mice compared with OVX mice. Consistently, MBOC increased the levels of osteocalcin and runt-related transcription factor 2 in OVX mice, as well as the expression of runt-related transcription factor 2, osterix, and alkaline phosphatase in C3H/10T1/2 cells. Mechanistically, MBOC activates the canonical Wnt/β-catenin signaling pathway via inhibiting phosphorylation of GSK-3β at Tyr216 and maintaining β-catenin expression. Collectively, the current study demonstrates the robustness of MBOC in the induction of mesenchymal stem cells osteogenic differentiation and consequent bone formation, suggesting that MBOC may be a potentially effective drug to treat postmenopausal osteoporosis. KEYWORDS bone metabolism, Maca, N-(3-methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide, postmenopausal osteoporosis, Wnt/β-catenin

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Anti-fatigue activity of polysaccharide fractions from Lepidium meyenii Walp. (maca)

Cited by 79 publications

References 25 publications

Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice

Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice

Optimization of Maca polysaccharide extraction process and its chemo‐protective effects on cyclophosphamide‐induced mice

N‐(3‐methoxybenzyl)‐(9Z,12Z,15Z)‐octadecatrienamide promotes bone formation via the canonical Wnt/β‐catenin signaling pathway

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