Anti-fatigue activity of a Lachnum polysaccharide and its carboxymethylated derivative in mice

Surhio, Maheen Mahwish; Wang, Yufen; Fang, Shi; Li, Jinglei; Ye, Ming

doi:10.1016/j.bmcl.2017.07.034

Cited by 41 publications

(19 citation statements)

References 37 publications

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“…Consequently, the excess production of SUN will reflect the protein decomposition which will attenuate the muscle contraction and induce fatigue. SUN level will significantly increase when body is poorly adapted for exercise tolerance [33,56]. In this study, after the exhaustive swimming (Figure 4(b)), SUN levels of CS-hEPS groups (100,150, 200 mg/kg) were reduced significantly (P < 0.01) by 58.09, 65.26, and 63.47%, respectively, compared to the group treated with saline solution.…”

Section: Discussionmentioning

confidence: 51%

“…In this study, after the exhaustive swimming (Figure 4(b)), SUN levels of CS-hEPS groups (100,150, 200 mg/kg) were reduced significantly (P < 0.01) by 58.09, 65.26, and 63.47%, respectively, compared to the group treated with saline solution. CS-hEPS reduced SUN level better than LEP-1b polysaccharide from Lachnum (19.77% at 200 mg/kg) [33]. Two mechanisms could explain these results: (1) CS-hEPS decrease protein catabolism and therefore maximize the exhaustive swimming time and/or (2) CS-hEPS improve hepatic glycogenesis which in turn controls protein catabolism.…”

Section: Discussionmentioning

confidence: 92%

“…Interestingly, it exhibited peculiar chemical characteristics, such as high uronic acid and sulfate contents, and importantly specific functional units, such as carboxymethyl, methoxyl, Journal of Chemistry and sulfated groups. Sulfated and/or carboxymethylated EPS have attracted attention in the field of pharmacology for their valuable biological activities [30,33,34]. Moreover, carboxymethylation and sulfation were applied to chemically modify polysaccharides for enhancing their bioactivities [33,34].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment

Chouchane¹,

Najjari

Chérif³

et al. 2020

Journal of Chemistry

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is study explored the possible use of a microbial carboxymethylated sulfated heteroexopolysaccharide (CS-hEPS) as a potential anticancer agent. e investigation was carried out through antioxidant, antifatigue, and antiproliferative activities. Antioxidant potential including scavenging DPPH and hydroxyl radical activities and reducing power was evaluated. Antifatigue activity was determined by assessing the endurance of mice using the forced swimming test. Following 30 days of CS-hEPS oral treatment at different doses, biochemical parameters related to fatigue such as lactic dehydrogenase (LDH), serum urea nitrogen (SUN), and hepatic glycogen (HG) contents were measured. Antitumor activities were investigated against human cancer liver and myelogenous leukemia cells. Results showed that CS-hEPS possesses notable antioxidant, antifatigue, and antitumor effects. CS-hEPS significantly inhibited the proliferation of leukemia (86.6 ± 0.32%) and cancer liver (58.6 ± 0.43%) cells. CS-hEPS are promising natural antioxidant, antifatigue, and antitumor harmless adjuvant materials that could be applied in human cancer therapy.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment

Chouchane¹,

Najjari

Chérif³

et al. 2020

Journal of Chemistry

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show abstract

“…Thus the catabolism of protein and amino acids is enhanced, and then the level of BUN, a metabolic product of protein and amino acid, also rises in the blood. The accumulation of BUN can cause the decomposition of muscle proteins in the body tissue, leading to muscle injury and fatigue . The BUN content of all experimental groups was less than that of the CG.…”

Section: Resultsmentioning

confidence: 85%

“…The accumulation of BUN can cause the decomposition of muscle proteins in the body tissue, leading to muscle injury and fatigue. 34 The BUN content of all experimental groups was less than that of the CG. Levels of BUN in PME-L and PME-H were significantly decreased by 10.33% and 10.55% compared with the CG (P < 0.05, Table 2).…”

Section: Effect Of Cme and Pme On Liver And Muscle Glycogenmentioning

confidence: 81%

Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice

Zheng

Zhang

et al. 2018

J Sci Food Agric

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Antifatigue effects and antioxidant activity in polysaccharide fractions from Chinese yam bulbils

Zhou,

Zhang,

Huang

et al. 2023

Food Science & Nutrition

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Polysaccharides are the principal component in Chinese yam (Dioscorea opposita Thunb.) bulbils. The properties and antifatigue of polysaccharides from yam bulbils (PYB) were identified and compared. Their molecular weights (PYB‐1 and PYB‐2) were approximately 145 and 11 kDa, respectively, with active β‐configurations. Meanwhile, the antifatigue activities of PYBs were tested in mice via exhaustive swimming tests (EST). The EST results indicated that PYB‐1 and PYB‐2 significantly prolonged swimming time in mice (p < .05). Associated with this increase was a rise in hepatic glycogen content and antioxidant enzyme (superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px)) activity, along with a decline in blood urea nitrogen, lactic acid, and malondialdehyde levels. The results showed that molecular weight might contribute to the antifatigue effects of PYBs. Additionally, antioxidant tests showed that PYB‐1 had stronger free‐radical scavenging activity than PYB‐2. Taken together, the findings indicated that PYBs exhibited effective antifatigue and antioxidant activities providing additional evidence supporting the use of PYBs as functional food ingredients for relieving fatigue.

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Anti-fatigue activity of a Lachnum polysaccharide and its carboxymethylated derivative in mice

Cited by 41 publications

References 37 publications

Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment

Carboxymethylated Sulfated Heteroexopolysaccharide from a Haloarchaeal Strain as Potential Biomolecule for Harmless Adjuvant Therapy in Cancer Treatment

Two macamide extracts relieve physical fatigue by attenuating muscle damage in mice

Antifatigue effects and antioxidant activity in polysaccharide fractions from Chinese yam bulbils

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