Anti-epileptic effects of valepotriate isolated from Valeriana jatamansi jones and its possible mechanisms

Wu, An Guo; Xia, Ye; Huang, Qiang; Dai, Weimin; Jian-min, Zhang

doi:10.4103/0973-1296.211027

Cited by 9 publications

(2 citation statements)

References 27 publications

(34 reference statements)

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“…Valerena-4,7(11)-diene from N. jatamansi reduced stress in animal studies [ 28 ]. Valepotriates from V. jatamansi and valtrates from V. laurifolia showed anticonvulsant properties in mice [ 122 , 132 ]. These studies show the variety of phytochemical compounds isolated from plant species under the sub-family Valerianaceae.…”

Section: Phytochemical Configuration Of Valerianaceaementioning

confidence: 99%

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Das

Shin

Tundis

et al. 2021

Plants

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Valerianaceae, the sub-family of Caprifoliaceae, contains more than 300 species of annual and perennial herbs, worldwide distributed. Several species are used for their biological properties while some are used as food. Species from the genus Valeriana have been used for their antispasmodic, relaxing, and sedative properties, which have been mainly attributed to the presence of valepotriates, borneol derivatives, and isovalerenic acid. Among this genus, the most common and employed species is Valerianaofficinalis. Although valerian has been traditionally used as a mild sedative, research results are still controversial regarding the role of the different active compounds, the herbal preparations, and the dosage used. The present review is designed to summarize and critically describe the current knowledge on the different plant species belonging to Valerianaceae, their phytochemicals, their uses in the treatment of different diseases with particular emphasis on the effects on the central nervous system. The available information on this sub-family was collected from scientific databases up until year 2020. The following electronic databases were used: PubMed, Scopus, Sci Finder, Web of Science, Science Direct, NCBI, and Google Scholar. The search terms used for this review included Valerianaceae, Valeriana, Centranthus, Fedia, Patrinia, Nardostachys, Plectritis, and Valerianella, phytochemical composition, in vivo studies, Central Nervous System, neuroprotective, antidepressant, antinociceptive, anxiolytic, anxiety, preclinical and clinical studies.

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Section: Phytochemical Configuration Of Valerianaceaementioning

confidence: 99%

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Das

Shin

Tundis

et al. 2021

Plants

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“…In some countries, V. officinalis was additionally a reasonably popular anticonvulsant remedy in the past ( Gorji and Khaleghi Ghadiri, 2001 ; Eadie, 2004 ). The aqueous extract of V. officinalis exerts effective antiepileptic action in the model of temporal lobe epilepsy ( Rezvani et al, 2010 ; Wu et al, 2017 ). It is believed that the pharmacological activity of V. officinalis depends on its antioxidant action, and data in the literature have pointed to a protective effect of V. officinalis in rotenone-induced neural toxicity ( Oliveira et al, 2009 ; Sudati et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Valeriana officinalis Counteracts Rotenone Effects on Spreading Depression in the Rat Brain in vivo and Protects Against Rotenone Cytotoxicity Toward Rat Glioma C6 Cells in vitro

et al. 2020

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Astrocytes can protect neurons against oxidative stress and excitability-dependent disorders, such as epilepsy. Valeriana officinalis has been used as anticonvulsant and can exert an antioxidant effect, which may underlie its opposing action against the toxic effects of the pesticide rotenone. We investigated the V. officinalis/rotenone interaction in the cortical spreading depression (CSD), a phenomenon that depends upon brain excitability (in vivo model). In addition, we analyzed the protective action of V. officinalis against the cytotoxic effects of rotenone in cultures of rat C6 glioma cells (in vitro model). For the CSD study, Wistar rats received either V. officinalis (250 mg/kg/day via gavage for 15 days; n = 8) or 10 mg/kg/day rotenone via subcutaneous injections for 7 days (n = 7), or they received both substances (n = 5). Two control groups received either saline (vehicle for V. officinalis; n = 8) or 1% Tween-80 aqueous solution (vehicle for rotenone; n = 9). After treatment, CSD was recorded for 4 h. The rotenone-and V. officinalistreated groups presented, respectively, with lower (2.96 ± 0.14 mm/min), and higher CSD propagation velocity (3.81 ± 0.10 mm/min) when compared with the controls (Tween-80, 3.37 ± 0.06 mm/min and saline, 3.35 ± 0.08 mm/min; p < 0.05). The rotenone plus V. officinalis-treated group displayed a CSD velocity (3.38 ± 0.07 mm/min) that was similar to controls. In line with these results, in vitro experiments on rat glioma C6 cells revealed a protective effect (MTT assay) of V. officinalis against rotenoneinduced cytotoxicity. These results suggest the therapeutic potential of V. officinalis for treating neurological diseases involving redox imbalance and astrocyte dysfunction.

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Unveiling the potential of native arbuscular mycorrhizal fungi for growth promotion and phytochemical enrichment in Valeriana jatamansi Jones

Tapwal,

Kumar,

Sharma

et al. 2024

Int Microbiol

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Anti-epileptic effects of valepotriate isolated from Valeriana jatamansi jones and its possible mechanisms

Cited by 9 publications

References 27 publications

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Valeriana officinalis Counteracts Rotenone Effects on Spreading Depression in the Rat Brain in vivo and Protects Against Rotenone Cytotoxicity Toward Rat Glioma C6 Cells in vitro

Unveiling the potential of native arbuscular mycorrhizal fungi for growth promotion and phytochemical enrichment in Valeriana jatamansi Jones

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