Anti Epileptic Activity of <i>Morinda citrifolia</i> Linn Fruit Extract

Muralidharan, P.; Srikanth, J.

doi:10.1155/2010/795804

Cited by 12 publications

(14 citation statements)

References 5 publications

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“…It was found that the reduction in these neurotransmitters including noradrenaline in the amygdala and the hippocampus, serotonin in the amygdala, DOPAC in the hippocampus and the substantia nigra, and HVA in the substantia nigra of the noni group might be responsible for anxiolytic effects of noni juice [ 8 ]. Conversely, it has been demonstrated that ethyl acetate fraction of crude methanol extract of M. citrifolia at a daily dose of 200 and 400 mg/kg which was administered to the rats for 15 days significantly increased the brain levels of serotonin, dopamine, and noradrenaline [ 7 ]. This opposing effect of noni on monoamine levels in two different studies could be due to the difference in the doses of noni used for these studies.…”

Section: Discussionmentioning

confidence: 99%

“…significantly decreased the apomorphine-induced cage climbing behaviour and methamphetamine-induced stereotypy behaviour in mice in a dose-dependent manner which demonstrated the antidopaminergic effect of noni fruit extract [ 6 ]. Furthermore, it was also reported that the administration of M. citrifolia fruit extract significantly increased the brain levels of serotonin, dopamine, and noradrenaline in rats [ 7 ]. Similarly, other neurochemical analysis of noni-treated rats (1 mL/day, p.o.)…”

Section: Introductionmentioning

confidence: 99%

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Effect of Noni (Morinda citrifoliaLinn.) Fruit and Its Bioactive Principles Scopoletin and Rutin on Rat Vas Deferens Contractility: AnEx VivoStudy

Pandy

Narasingam

Kunasegaran

et al. 2014

The Scientific World Journal

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This study examined the effect of methanolic extract of Morinda citrifolia Linn. (MMC) and its bioactive principles, scopoletin and rutin, on dopamine- and noradrenaline-evoked contractility in isolated rat vas deferens preparations. MMC (1–40 mg/mL), scopoletin (1–200 μg/mL), and rutin hydrate (0.6–312.6 μg/mL) dose-dependently inhibited the contractility evoked by submaximal concentrations of both dopamine and noradrenaline, respectively. Haloperidol and prazosin, reference dopamine D2, and α 1-adrenoceptors antagonists significantly reversed the dopamine- and noradrenaline-induced contractions, respectively, in a dose-dependent manner. Interestingly, MMC per se at higher doses (60–100 mg/mL) showed dose-dependent contractile response in rat vas deferens which was partially inhibited by high doses of haloperidol but not by prazosin. These results demonstrated the biphasic effects of MMC on dopaminergic system; that is, antidopaminergic effect at lower concentrations (<40 mg/mL) and dopaminergic agonistic effect at higher concentrations (>60 mg/mL). However, similar contractile response at high doses of scopoletin (0.5–5 mg/mL) and rutin hydrate (0.5–5 mg/mL) per se was not observed. Therefore, it can be concluded that the bioactive principles of MMC, scopoletin, and rutin might be responsible for the antidopaminergic and antiadrenergic activities of MMC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Noni (Morinda citrifoliaLinn.) Fruit and Its Bioactive Principles Scopoletin and Rutin on Rat Vas Deferens Contractility: AnEx VivoStudy

Pandy

Narasingam

Kunasegaran

et al. 2014

The Scientific World Journal

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“…M. citrifolia fruit extract possesses protective effects against seizures induced by maximal electro shock in the rats. The noni juice administration regulates dopamine, serotonin and noradrenaline levels in forebrain region of epileptic patients (Muralidharan & Srikanth, ). The leaf extracts of M. citrifolia increases stamina by decreasing levels of blood lactate and blood urea nitrogen.…”

Section: Pharmacology Of Indian Morinda Speciesmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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“…11 In our past study we reported the antiepileptic activity of Morinda citrifolia Linn fruit extract against seizures instigated by Maximal Electro Shock (MES) technique in rats. 12 Köktürk et al assessed the neuroprotective impacts of Morinda citrifolia L. (Rubiaceae), regularly known as Noni, and memantine on hydrocephalus-actuated neurodegenerative disorders. 13 Pandy et al showed the antidopaminergic impact of Morinda citrifolia Linn.…”

Section: Introductionmentioning

confidence: 99%

In vitro & ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract

Jeyabalan¹,

Subramanian²,

Cheekala³

et al. 2017

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Background: Psychological problem is a key medical issue for numerous neuropsychiatric and neurodegenerative diseases, for example, schizophrenia, Alzheimer's, dementia, seizure and Parkinsonism. Morinda citrifolia (Noni) has been utilized for a considerable length of time to cure or counteract assortment of diseases by conventional therapeutic professionals in Hawaii and Polynesia. Objective: The present study is focused to identify the neuroprotective activity of Morinda citrifolia fruit extract (MCFE) on in vitro and ex vivo animal model by inhibition of acetylcholinesterase (AChE), an enzyme target used for the treatment of Alzheimer's disease. Methods: Acetylcholinesterase inhibition assay was performed by in vitro & ex vivo methods as described by Ellman et al. In vitro antioxidant assay of the extract was performed by DPPH free radical scavenging activity & nitric oxide scavenging activity. Statistical analysis used: Statistical analysis was carried out using non linear regression analysis for plotting the line of best fit for the observed values using GraphPad Prism software. Results: By performing in vitro antioxidant assay the IC 50 value of the standard quercetin was found to be 46.22 µg/ml as compared to the MCFE which has an IC 50 value of 43.14 µg/ml for DPPH free radical scavenging activity. Similarly the IC 50 value of the standard ascorbic acid was found to be 81.85 µg/ml as compared to the MCFE which has an IC 50 value of 148.0 µg/ml for nitric oxide scavenging activity. Acetylcholinesterase inhibition assay was performed by in vitro method and the IC 50 value of MCFE and neostigmine was found to be 31.84 µg/ml & 19.71 µg/ml respectively. Conclusions: The present study investigated the neuroprotective activity of MCFE and it was identified by both in vitro and ex vivo techniques that the phytoconstituents has the ability to improve the learning and memory function by inhibiting the acetylcholinesterase. Key words:Morinda citrifolia, Noni, Acetylcholinesterase, Neuroprotective activity, in vitro, ex vivo. Key Messages: The present study investigated the neuroprotective activity of Morinda citrifolia and it was identified by both in vitro and ex vivo techniques that the phytoconstituents in the plant can improve the learning and memory function by inhibiting the acetylcholinesterase. Further the antioxidant potential of the plant was also evident from the DPPH and nitric oxide scavenging activity. Future studies may be designed for chronic administration of Morinda citrifolia to further investigate the effect on in vivo experimentation and also to identify the safety and efficacy parameters at both preclinical and clinical stages.

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Anti Epileptic Activity of Morinda citrifolia Linn Fruit Extract

Cited by 12 publications

References 5 publications

Effect of Noni (Morinda citrifoliaLinn.) Fruit and Its Bioactive Principles Scopoletin and Rutin on Rat Vas Deferens Contractility: AnEx VivoStudy

Effect of Noni (Morinda citrifoliaLinn.) Fruit and Its Bioactive Principles Scopoletin and Rutin on Rat Vas Deferens Contractility: AnEx VivoStudy

Indian Morinda species: A review

In vitro & ex vivo Acetylcholinesterase Inhibitory Activity of Morinda citrifolia Linn (Noni) Fruit Extract

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