Anti-diabetic effects of pomegranate extracts in long-term high fructose-fat fed rats

Abstract

Background: A high-sugar or/and high-fat diets is a major risk factors for obesity. However, increased fruit and vegetable intake has been recently linked to obesity prevention. The aim of the present study was to investigate the preventive effects of pomegranate leaves (PL), juice (PJ) and peel (PP) extracts, on insulin resistance and oxidative stress in high fat and high fructose diet-induced obese rats. Methods: Obesity in rats was induced by consumption of diet high in saturated fat and fructose (HFD) for a long period (12 weeks). Results: Compared to the control group (CG) fed chow died, the high fat and high fructose diet (HFD) group showed a significant increase in the fasted plasma levels of glucose (29.8%), insulin (45%), amylase (70%) and lipase (54%). Moreover, HFD feeding has increased lipid peroxidation and protein carbonylation and decreased antioxidant enzymes levels. However, PL, PJ and PP treatment markedly prevents glucose intolerance, insulin resistance and oxidative stress and decrease amylase and lipase levels. Conclusion: These findings highlight that a long-term intake of pomegranate extracts might be a potential alternative strategy for the prevention of a HFD induced insulin resistance and oxidative stress.

Amelioration of Cell Phone and Wi Fi induced Pancreatic Damage and Hyperglycemia (Diabetes Mellitus) with Pomegranate and Vit E in Rats

“…Regarding damage to the body cells i.e beta cells results of our study tally with the previous studies [24][25][26]. Pomegranate's anti-oxidant and anti-diabetic effects observed in this study are in conformity with the previous studies [27,28]. In previous studies it has been found that pomegranate is rich in flavonoids [29].…”

Integrating phytochemical profiling, <i>in vitro</i> studies and network pharmacology to reveal the antidiabetic action mechanism of <i>Punica granatum</i> fruit peel

“…between multiple target proteins and a single pathway. These findings imply that the potent pharmacological components of P. granatum may act on these signalling pathways to alleviate the levels of insulin, glucose, inflammation, and oxidative stress associated with diabetes and other related diseases (Amri et al, 2020;Tang et al, 2018).…”

Health Benefits of Pomegranate (Peel & Juice) and Preparation of Functional Pomegranate Drink Using Probiotic Lactobacillus Plantarum

“…Due to their improved nutritional value, sensory qualities, improved storage life, and addition of derived components that promote health, fermented fruit beverages serve functional manufacturing needs (Hua et al, 2021). (Amri et al, 2020) shows that leaves, rind, or juice extracts of pomegranate promote decrease insulin sensitivity and promote glycemic control, and limit carbohydrate and lipid absorption by lowering the activities of amylase and lipase. (Andi Alfira et al, 2020) studied In Vitro that the peel powder of fruit Pomegranate had great effect on amylase inhibitor.…”