Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats

Zhang, Yao; Ren, Chunjiu; Lu, Guobing; Mu, Zhimei; Cui, Wei-Zheng; Gao, Huiju; Wang, Yanwen

doi:10.1016/j.intimp.2014.06.039

Cited by 110 publications

(58 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This plant was identified to have various phytochemical components (Ishida et al, 2004;Kubola & Siriamornpun, 2011). These fruits have been reported to have antioxidant activity (Kubola & Siriamornpun), anti-inflammatory effect (Jung et al, 2013), immunomodulatory activity (Tsoi et al, 2006), antitumor properties (Chuethong et al, 2007), anti-cancer activity (Zheng et al, 2014;Petchsak & Sripanidkulchai, 2015). However, there was no report of the hypoglycemic effect of Gac aril (GA) on adverse male reproductive system in type-I DM animal model.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice

et al. 2017

View full text Add to dashboard Cite

SUMMARY:The aim of present study was to investigate the effect of Momordica cochinchinensis (Gag) aril (GA) aqueous extract on male reproductive system of streptozotocin (STZ)-induced hyperglycemia (HG) mice. GA were extracted with distilled water (DW) and analyzed for in vitro antioxidant capacities. ICR male mice were divided into 7 groups: 1) control, 2) DW, 3) GA 1000 mg/kg BW, 4) HG, 5) HG + glibenclamide, 6 and 7) HG + GA 500 and 1000 mg/kg BW respectively (7 mice/ group). In HG groups, mice were induced by STZ at single dose (150 mg/kg BW). They were treated for consecutive 35 days. All groups were compared for blood glucose levels, weights and histopathologies of reproductive organs, sperm concentration including testicular tyrosine phosphorylation protein patterns by Immuno-Western blotting. The results showed that GA processed antioxidant activities and could significantly decrease blood glucose levels and increase sperm concentration in HG mice. Moreover, GA could change the density of a testicular 70 kDa protein in HG-GA groups. In conclusion, GA extract could improve hyperglycemia and male reproductive damages in STZ-induced HG mice.

show abstract

Section: Introductionmentioning

confidence: 99%

Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Mulberry leaf (Folium Mori), the leaf of Morus alba L. (Moraceae), has been used as one of the ingredients in traditional Chinese medicine (TCM) for the treatment of diabetes (Zhang et al 2014;Wilson & Islam 2015), atherosclerosis (Sugimoto et al 2009;Chan et al 2013) and as an immune booster due to its antioxidant potential (Bharani et al 2010;Yimam et al 2015). Mulberry leaf extract has previously been reported to ameliorate T2DM symptoms and complications, such as dyslipidemia (Trimarco et al 2015), diabetic nephropathy and impaired liver functions (Wilson & Islam 2015).…”

Section: Introductionmentioning

confidence: 99%

Effect of mulberry leaf (Folium Mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats

Cai

Sun

Yang

et al. 2016

Pharmaceutical Biology

View full text Add to dashboard Cite

(2016) Effect of mulberry leaf (Folium Mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats, Pharmaceutical Biology, 54:11, 2685-2691, DOI: 10.1080/13880209.2016 Context: Folium Mori, the leaf of Morus alba L. (Moraceae), has been used in traditional Chinese medicine (TCM) for treating diabetes. However, it is unclear which components in the mulberry leaf are effective for the treatment of type 2 diabetes mellitus (T2DM). Objective: To investigate the flavonoids and polyphenols in mulberry leaves and their antihyperglycemic and antihyperlipidemic effects in T2DM rats. Materials and methods: Male Sprague-Dawley rats were divided into five groups: normal control (NC), diabetic control (DBC), diabetic group with 0.3 mg/kg b.w./day rosiglitazone (RSG), diabetic group with 7 g/kg b.w./day TCM formula and diabetic group with 2 g/kg b.w./day Folium Mori extract (FME). After 4 weeks, the rats were sacrificed; biochemical parameters, gene and protein expression were measured. Results: The FBG level was significantly lower in the FME group than in the DBC group (p < 0.05). In oral glucose tolerance test, the AUC was significantly lower in the FME group (p < 0.05). The HOMA-IR level was significantly decreased in the FME group (p < 0.05). FME decreased the total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) levels (p < 0.05). FME increased the mRNA and protein expression of IRS-1, PI3K p85a and Glut-4 increased significantly (p < 0.05). Histological analysis revealed amelioration of lipid accumulation following FME treatment. Additionally, immunohistochemical analysis displayed stronger staining of Glut-4 in the FME group compared to the DBC group. Discussion and conclusion: FME could decrease the body weight, blood glucose, TG, TC and LDL levels, and improve insulin resistance. FME possessed significant antihyperglycemic and antihyperlipidemic activities via the IRS-1/PI3K/Glut-4 signalling pathway. ARTICLE HISTORY

show abstract

“…39 Polysaccharides from mulberry leaf have been shown to elevate the Bcl-2/Bax ratio to protect pancreatic islet cells from apoptosis. 40 However, the Bcl-2 family is divided into 3 subgroups, 41 thus further study is needed to determine which proteins are altered when mulberry leaf is administered.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Current anti-diabetes mechanisms and clinical trials using Morus alba L.

Tian

Tang

Zhao

2016

Journal of Traditional Chinese Medical Sciences

View full text Add to dashboard Cite

show abstract

Anti-diabetic effect of mulberry leaf polysaccharide by inhibiting pancreatic islet cell apoptosis and ameliorating insulin secretory capacity in diabetic rats

Cited by 110 publications

References 55 publications

Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice

Antioxidant and Hypoglycemic Effects of Momordica cochinchinensis Spreng: (Gac) Aril Extract on Reproductive Damages in Streptozotocin (STZ)-Induced Hyperglycemia Mice

Effect of mulberry leaf (Folium Mori) on insulin resistance via IRS-1/PI3K/Glut-4 signalling pathway in type 2 diabetes mellitus rats

Current anti-diabetes mechanisms and clinical trials using Morus alba L.

Contact Info

Product

Resources

About