Anti-Diabetic Effect of Morinda lucida Stem Bark Extracts on Alloxan-Induced Diabetic Rats

Odutuga, A.A.; Dairo, J O; Minari, J. B.; Bamisaye, F. A.

doi:10.3923/rjpharm.2010.78.82

Cited by 17 publications

(12 citation statements)

References 5 publications

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“…This could be an indication that medicinal activities of plants are readily available when the plants are freshly collected as some of their metabolites may be volatile and could be lost through evapotranspiration. This corroborates the findings of [22,23,69,71] who reported that fresh plant material was used to prepare remedies as mixtures of multiple ingredients from different plants. The number of plants in mixture ranged from four to ten.…”

Section: Threats and Vulnerability Assessment Of Medicinal Plants Usesupporting

confidence: 91%

“…Leaf was the most commonly used plant part in the area, the harvest of which does not normally causes significant harm to survival of individuals as compared to other parts such as the stem, bark and root. This could be explained by the fact that leaves are sites where more phytochemicals are produced via photosynthesis [69,70]. This finding is in agreement with those of certain others [15,17,18].…”

Section: Threats and Vulnerability Assessment Of Medicinal Plants Usesupporting

confidence: 77%

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Diversity, Ethnobotanical Potential and Sustainability Assessment of Plants Used by Traditional Healers to Treat Cancer in Boyo Division, North-West Region, Cameroon

Avana-Tientcheu

Sime²,

Roger

et al. 2019

EJMP

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Aims: Cancer is the second leading cause of death globally. Therefore, the knowledge on medicinal plants used to cure human cancer could be of great importance for their widespread use and scientific validation. The present study records information on anticancer plants in Boyo Division, in the western highland of Cameroon. Methods: Thirty traditional healers, were interviewed to document their know-how on the type of human cancer allegedly cured, the plant species used as well as their use pattern. Guided field walks were made to the collection sites for plant and its habitat characterization as well as herbarium voucher collection. Ethnobotanical quantitative tools were used to analyze and summarize collected data. Sustainability of harvest was assessed using a vulnerability index based on seven parameters. Results: A total of 25 medicinal plants cited were identified as belonging to 13 families and 23 genera. The most represented families were Asteraceae (28%), Lamiaceae (16%), Fabaceae (12%) and Acanthaceae (8%). Out of the seven categories of cancer diseases reported, the highest number of plants species were reported to treat stomach, pancreas, liver, skin and breast cancers, with informant consensus factor (ICF) ranging from 0.79 to 0.82. Leaves (60%) and bark (20%) were the major plant parts used mostly in form of decoction (45.45%) and concoction (38.18%). The result of Relative frequency citations (RFCs) revealed that 9 of the 25 plants species cited were the most frequently used with fidelity levels ranging from 92% (Geniosporum rotundifolium and Ocimum tenuiflorum Aframomum melegueta and Entada abyssinica) to 100% (Coleus blumei, Ocimum gratissimum, Eremomastax speciosa, and Dichrocephala integrifolia). Six species were assessed as vulnerable (Vi ≥ 2), while two species were rated as highly vulnerable namely G. rotundifolium (Vi = 2.71) and E. abyssinica (Vi = 2.85). Conclusion: New traditionally effective anticancer plants were identified in the present study, some of which were already vulnerable for exploitation in their actual habitat. Plants with high ICF, RFCs and FL values should be subjected to further phytochemical and pharmacological investigations for scientific validation while those with high Vulnerability index should be recommended for participatory domestication by the main users.

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Section: Threats and Vulnerability Assessment Of Medicinal Plants Usesupporting

confidence: 91%

Section: Threats and Vulnerability Assessment Of Medicinal Plants Usesupporting

confidence: 77%

Diversity, Ethnobotanical Potential and Sustainability Assessment of Plants Used by Traditional Healers to Treat Cancer in Boyo Division, North-West Region, Cameroon

Avana-Tientcheu

Sime²,

Roger

et al. 2019

EJMP

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“…This observation is in line with the findings of Jain and Longerhan (32) which reported a hypoglycemic effect in alloxan-induced diabetic rats at 200 and 400mg/kg with the use of Spinaciaoleraceae. Also, Odutugaet al, (33) , in his investigation on anti-diabetic effect of Morindalucidastem bark extract on alloxan -induced diabetic rats reported maximum percentage reduction of 73.5 and 93.0% in blood glucose concentration of metanolic leave extract of Morindalucida at 240 mg/kg body weight.…”

Section: Discussionmentioning

confidence: 93%

Antidiabetic Effect of Ipomoea Batatas in Normal and AlloxanInduced Diabetic Rats

T.O¹,

A²,

A.A³

et al. 2014

IOSRJAC

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“…These enzymes are released into the serum especially when there is damage to the hepatic membrane as a result of chemical assaults. Serum levels of these enzymes therefore are significant diagnostic tools in assessing the level of hepatic damage (Oluba et al, 2008;Odutuga et al, 2010;Bamisaye et al, 2013). Therefore, their presence in the serum of the powders-treated animals may be suggesting information on the tissue injury or dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Toxicological and Histopathological Effects of Cheese Wood, <i>Alstonia boonei</i> De Wild Stem Bark Powder used as Cowpea Protectant against Cowpea Bruchid, <i>Callosobruchus maculatus</i> (Fab.) [Coleoptera: Chrysomelidae] on Albino Rats.

Ileke

Odeyemi²,

Ashamo³

2014

ijmms

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Toxicological and histopathological effects of Alstonia boonei stem bark powder on albino rats liver and kidney functions were investigated using standard methods. After two weeks of acclimatization, the rats were randomly divided into four (I-IV) groups of six animals each. Group I was fed with Basal Diet, group II-IV were for 30 days with Basal Diet containing 1%, 4% and 10% A. boonei stem bark powder, respectively. Blood was rapidly collected by direct heart puncture and the plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total protein, urea and creatinine contents were determined using commercially-available kits. The levels of these biochemical functions were also determined in the liver and kidney. The A. boonei stem bark powder at 10% concentration caused oxidative liver and kidney damages. Histopathological results of the liver shows that the group fed with 4% A. boonei stem bark powder had normal hepatocytes. The group fed with 10% A. boonei stem bark powder had necrosis. The results of the present study showed that the supplementation of 1% and 4% A. boonei stem bark powder to the diets of rats for 30 days did not change the biochemical parameters of liver and kidney as well as histopathological investigation which illustrated normal architecture of liver and kidney.

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Anti-Diabetic Effect of Morinda lucida Stem Bark Extracts on Alloxan-Induced Diabetic Rats

Cited by 17 publications

References 5 publications

Diversity, Ethnobotanical Potential and Sustainability Assessment of Plants Used by Traditional Healers to Treat Cancer in Boyo Division, North-West Region, Cameroon

Diversity, Ethnobotanical Potential and Sustainability Assessment of Plants Used by Traditional Healers to Treat Cancer in Boyo Division, North-West Region, Cameroon

Antidiabetic Effect of Ipomoea Batatas in Normal and AlloxanInduced Diabetic Rats

Toxicological and Histopathological Effects of Cheese Wood, <i>Alstonia boonei</i> De Wild Stem Bark Powder used as Cowpea Protectant against Cowpea Bruchid, <i>Callosobruchus maculatus</i> (Fab.) [Coleoptera: Chrysomelidae] on Albino Rats.

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