Anti diabetic effect of ethanolic extract of leaves of Ocimum sanctum in alloxan induced diabetes in rats

S, Abhilash Rao; Yadav, Vijay; Deepthi, T; Srinivasan, Lakshmi; Rani, Vibha; Rani, Swetha; Y, Bhuvaneswara Reddy; P, Ram Swaroop; Laxmi, S. Bhavana; K, Nikhil Chakravarthy; Arun, Pattatheyil

doi:10.5455/2319-2003.ijbcp20131018

Cited by 12 publications

(2 citation statements)

References 4 publications

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“…Basil leaves, herbs from the Ocimum family have been proposed to possess antihyperglycemic properties in multiple studies [16], [17], [20], [29], [30], [31]. This study found significant blood glucose -lowering effect and endothelial protection of basil leaves.…”

Section: Discussionmentioning

confidence: 66%

Antihyperglycemic, Endothelial protection and Toxicity study of Basil Leaves Extract on Diabetic Rats

Widjaja

Rusdiana²,

Maya

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Diabetes Mellitus (DM) remains a serious debilitating global health problem in low- and middle-income countries with rising incidence of DM-related complications due to ineffective Diabetic control. Herbs of the Ocimum family, especially Ocimum basilicum or basil leaves, have been investigated for their antihyperglycemic properties. AIM: This study aimed to demonstrate the antihyperglycemic effect, endothelial protection, and toxicity of basil leaves on Diabetes-induced Wistar rats in vivo. METHODS: Streptozosin injections were used to induced diabetes in male Wistar rats. Basil leaves extracts 100, 300, and 1000 mg/kg BW were introduced to diabetic rats. Blood glucose levels (BGL), soluble Advanced Glycation End, tumor necrosis factor-α, interleukin (IL)-6, IL-2 were measured using enzyme-linked immunosorbent assay. Kidney and liver functions together with the histopathology reports were reported for acute, subacute, and chronic toxicity studies. RESULTS: Basil leaves exposure significantly lowers BGL (p < 0.00), but yielded no statistically significant difference between extract doses. Hemostatic parametersshowed significantly reduced endothelial dysfunction markers for all doses compared to control. Toxicity study yielded no differences between control and any doses of basil leaves in all acute, subacute, and chronic toxicity studies. Histopathological findings exhibited no evidence of tissue damage on the liver, kidney, heart, pancreas, lung, and lymph tissues in either control or experiment rats. CONCLUSIONS: Basil leaves exposure were positively associated with lower glucose level, lower endothelial activation markers on Diabetic rats. The toxicity and histopathological results of the extract are on par with control.

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Section: Discussionmentioning

confidence: 66%

Antihyperglycemic, Endothelial protection and Toxicity study of Basil Leaves Extract on Diabetic Rats

Widjaja

Rusdiana²,

Maya

et al. 2021

Open Access Maced J Med Sci

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“…Furthermore, oral administration of an ethanolic leaf extract led to marked lowering of blood sugar in animal and laboratory models of diabetes mellitus [278,279], and the O. temuiflorum-containing polyherbal Ayurvedan supplement Diabecon® seemed efficacious and safe in helping control blood sugar levels in diabetics [280]. In addition, ethanol and chloroform leaf and stem extracts protected rats to a comparable extent as phenytoin from tonic convulsions induced by transcorneal electroshock [281].…”

Section: Lamiaceae-ocimum Tenuiflorum Lmentioning

confidence: 99%

Traditional Plant-Based Treatments of Fungal Infections in the Republic of Suriname (South America): Phytochemical and Pharmacological Rationales

Mans¹

2022

Traditional Plant-Based Forms of Treatment of Fungal Infections in Suriname - Phytochemical and Pharmacological Rationale

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Fungi are unicellular or multicellular thick-walled eukaryotic organisms that are not capable of photosynthesis and are placed in a biological kingdom of their own. They are ubiquitous in our environment, and include tens of thousands, perhaps even millions of species of yeasts, rusts, smuts, mildews, molds, and mushrooms. Together with bacteria, fungi are the principal decomposers of plant materials such as cellulose and lignin, fulfilling vital ecological functions in all terrestrial habitats. Some species of fungi are also of major importance in households (for instance, as foods such as edible mushrooms), medicine (for instance, as producers of antibiotics such as penicillin), and industry (for instance, for making bread, wine, and cheese). About 300 fungal species cause infections in humans, varying from relatively harmless skin complaints such as pityriasis versicolor to potentially life-threatening systemic syndromes such as candidiasis. Fortunately, a broad armamentarium of efficacious antifungal drugs has been developed, ranging from topical nystatin to parenteral amphotericin B. In addition, most, if not all traditional medical systems throughout the world have identified a large assortment of plant-based remedies for treating these infections. This also holds true for the multi-ethnic and multicultural Republic of Suriname (South America), where plant-based traditional medicines are abundantly used, either alone or in conjunction with allopathic medications. This monograph extensively addresses nine plants that are traditionally used for treating fungal infections in Suriname, and explains the phytochemical and pharmacological rationales for these applications. These sections are preceded by some general observations about the Fungal Kingdom; a few words about the characteristics of fungi, their taxonomy, and their significance to humans; information about fungal infections as well as the available forms of treatment; and some details about Suriname including health aspects, the health care structure, and the main fungal infections in the country. The monograph is concluded with an evaluation of the status of the Surinamese herbal antifungal substances and the previsions of developing them into mainstream antifungal formulations.

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Climate Change: Threat of Era

Mitra

Zaman

2020

Environmental Science - A Ground Zero Observation on the Indian Subcontinent

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Anti diabetic effect of ethanolic extract of leaves of Ocimum sanctum in alloxan induced diabetes in rats

Cited by 12 publications

References 4 publications

Antihyperglycemic, Endothelial protection and Toxicity study of Basil Leaves Extract on Diabetic Rats

Antihyperglycemic, Endothelial protection and Toxicity study of Basil Leaves Extract on Diabetic Rats

Traditional Plant-Based Treatments of Fungal Infections in the Republic of Suriname (South America): Phytochemical and Pharmacological Rationales

Climate Change: Threat of Era

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