Anti-diabetic Effect of Anthocleista vogelii Ethanolic Root Extract and Fractions in Streptozotocin-induced Diabetic Albino Rats

Reporting the toxicological profile of methanolic leaf extract of <i>Anthocleista vogelii</i> Planch on Wistar rats

“…Since there was no death observed throughout the experimentation, the extrapolated LD50 value of the plant was concluded to exceed 3200 mg/kg. This development corresponded with previous reports that the LD50 of leaf extract of A. vogelii exceeded limit dose rate of 2000 mg/kg, suggesting its consideration as innocuous plant material (Anyanwu et al, 2013;Sunday et al, 2014). The harmless nature of methanolic leaf extract was also associated with its capacity not to cause significant depression of growth processes and alteration of cellular metabolism (Anderson et al, 1999;Ige et al, 2011;Nadir and Suat, 2007).…”

“…The chemical constituents validating their pharmacologic properties were earlier reported to be found in the roots, stems and leaves of A. vogelii, and the various bioactive compounds notably; alkaloids, terpenoids, anthraquinones, saponins, tannins, flavonoids, steroids and phenolics with the exception of glycosides were scientifically revealed (Anyanwu et al, 2013;Anyanwu et al, 2015;Apiamu et al, 2017;Gboeloh et al, 2014;Jegede et al, 2011). To this end, the aerial parts of the plant distinctly and evidently exhibited antidiabetic, antiplasmodial, antimicrobial, antihypertensive and antihypotensive, spasmolytic and spasmogenic, anti-obesity and antioxidant properties respectively (Alaribe et al, 2012;Anyanwu et al, 2013;Ateufack et al,2 0 1 0 ;Christophe et al, 2015;Okokon et al, 2012;Olubomehin et al, 2013;Sunday et al, 2014). Therefore, the present study explains the toxicological profile of methanolic leaf extract of A. vogelii Planch on rat models via monitoring of toxicity-related biomarkers.…”

An overview of anti-diabetic plants used in Gabon: Pharmacology and toxicology

“…In vivo: Leaves, stem bark and roots methanol extracts (1g/kg) given orally to albino rats for 7 days exhibited blood glucose reduction (Olubomehin et al, 2013). Ethanolic extract of roots (100, 200 and 400 mg/kg) and fractions (ethyl acetate, dichloromethane and hexane) at 200 mg/kg each administered to STZ-induced diabetic rats exerted antidiabetic and antihyperlipidemic activity comparing with glibenclamide (Sunday et al, 2017) In vitro: Alphaamylase inhibitory activity of leaves, stem bark and roots methanol extract (1ml of 250 mg/ml) (Olubomehin et al, 2013) Antimicrobial Antimalarial, Analgesic, Hepatoprotective (Iroanya et al, 2015;Gboeloh et al, 2014;Osadebe et al, 2014;Mbiantcha et al, 2014;Alaribe et al, 2012) Gnetaceae (Ngondi et al, 2009). Single oral administration of methanol extract of seeds at doses 150 and 250 mg/kg significantly reduced plasma glucose levels in STZ-induced diabetic rats 2h after administration, with 250 mg/kg more efficient than 150 mg/kg (Ngondi et al, 2006).…”

Effect of Anthocleista vogelii leaves on free radicals: Antioxidant studies

“…Anthocleista vogelii belonging to the family Loganiaceae is a plant used in ethno-medicine for the treatment of various diseases which includes fever, syphilis, pile and stomach ache [11,12] . Previous studies reported that Anthocleista vogelii root exerted antidiabetic effect in albino rats that were induced with diabetes using streptozocin and alloxan [13,14] . Previous studies also reported the presence of phenolic content and antioxidant property of Anthocleista vogelii root [11] .…”