Anti-diabetic effect of aloin via JNK-IRS1/PI3K pathways and regulation of gut microbiota

Zhong, Ruting; Chen, Lanbin; Liu, Yuanyuan; Xie, Shouqi; Li, Sumei; Liu, Bin; Zhao, Chao

doi:10.1016/j.fshw.2021.07.019

Cited by 17 publications

(12 citation statements)

References 57 publications

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“…Lachnospiraceae _NK4A136_group belongs to the Firmicutes phylum, which regulates host health through butyric acid production. Compared with group C [46], the abundance of the Lachnospiraceae _NK4A136_group in diabetic mice decreased significantly and increased after TGP treatment. However, the relative abundance of Desulfovibrio and norank_f_Lachnospiraceae were higher in diabetic mice than in mice in the C, B, and NH groups.…”

Section: Discussionmentioning

confidence: 83%

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Jiang¹,

Chen²,

Wang³

et al. 2024

Food Science and Human Wellness

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Type 2 diabetes mellitus (T2DM) is a complex metabolic disease threatening human health. We investigated the effects of Tegillarca granosa polysaccharide (TGP) and determined its potential mechanisms in a mouse model of T2DM established through a high-fat diet and streptozotocin. TGP (5.1×10 3 Da) was composed of mannose, glucosamine, rhamnose, glucuronic acid, galactosamine, glucose, galactose, xylose, and fucose. It could significantly alleviate weight loss, reduce fasting blood glucose levels, reverse dyslipidemia, reduce liver damage from oxidative stress, and improve insulin sensitivity. RT-PCR and western blotting indicated that TGP could activate the phosphatidylinositol-3-kinase/protein kinase B signaling pathway to regulate disorders in glucolipid metabolism and improve insulin resistance. TGP increased the abundance of Allobaculum, Akkermansia, and Bifidobacterium, restored the microbiota abundance in the intestinal tracts of mice with T2DM, and promoted short-chain fatty acid production. This study provides new insights into the antidiabetic effects of TGP and highlights its potential as a natural hypoglycemic nutraceutical.

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Section: Discussionmentioning

confidence: 83%

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Jiang¹,

Chen²,

Wang³

et al. 2024

Food Science and Human Wellness

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“…Of note, the activated JNK signaling pathway inhibits IRS1 and thereby inhibits downstream pathways [32]. The impact of JNK-IRS1/PI3K pathways on glucose metabolism was studied in DXMS-stimulated IR-HepG2 cells [48]. On the other hand, Nrf2, as a key transcription factor regulating oxidative stress, has become a new anti-diabetic target [49].…”

Section: Discussionmentioning

confidence: 99%

3,3′,4,5′-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress

Tan

Miao

Xiao

et al. 2022

CIMB

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The potential anti-diabetic effect of resveratrol derivative, 3,3′,4,5′-tetramethoxy-trans-stilbene (3,3′,4,5′-TMS) and its underlying mechanism in high glucose (HG) and dexamethasone (DXMS)-stimulated insulin-resistant HepG2 cells (IR-HepG2) were investigated. 3,3′,4,5′-TMS did not reduce the cell viability of IR-HepG2 cells at the concentrations of 0.5–10 µM. 3,3′,4,5′-TMS increased the potential of glucose consumption and glycogen synthesis in a concentration-dependent manner in IR-HepG2 cells. 3,3′,4,5′-TMS ameliorated insulin resistance by enhancing the phosphorylation of glycogen synthase kinase 3 beta (GSK3β), inhibiting phosphorylation of insulin receptor substrate-1 (IRS-1), and activating phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway in IR-HepG2 cells. Furthermore, 3,3′,4,5′-TMS significantly suppressed levels of reactive oxygen species (ROS) with up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) expression. To conclude, the beneficial effect of 3,3′,4,5′-TMS against insulin resistance to increase glucose consumption and glycogen synthesis was mediated through activation of IRS/PI3K/Akt signaling pathways in the IR-HepG2 cells, accomplished with anti-oxidative activity through up-regulation of Nrf2.

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“…Meanwhile, the Bacteroidetes/ Firmicutes ratio was determined to be negatively correlated with blood glucose concentrations and markedly reduced in patients with diabetes or obesity. 30 The results showed that the B/F ratio was significantly increased by 1.7-fold in the SCH group when compared to that in the HFD mice. Previous studies have reported that "overnutrition" is associated with increased Firmicutes and decreased Bacteroidetes.…”

Section: Paper Food and Functionmentioning

confidence: 92%

Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota

Chen

Jiang

et al. 2023

Food Funct.

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Anti-diabetic effect of aloin via JNK-IRS1/PI3K pathways and regulation of gut microbiota

Cited by 17 publications

References 57 publications

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye

3,3′,4,5′-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress

Sciadonic acid attenuates high-fat diet-induced obesity in mice with alterations in the gut microbiota

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