Anti-diabetic and hypolipidaemic properties of ginger ( Zingiber officinale) in streptozotocin-induced diabetic rats

Abstract

In the present study, the hypoglycaemic potentials of ginger (Zingiber officinale) were studied in rats. An aqueous extract of raw ginger was administered daily (500 mg/kg, intraperitoneally) for a period of 7 weeks to streptozotocin (STZ)-induced diabetic rats. Fasting blood serum was analysed for blood glucose, cholesterol and triacylglycerol levels. The STZ-injected rats exhibited hyperglycaemia accompanied with weight loss, indicating their diabetic condition. At a dose of 500 mg/kg, raw ginger was significantly effective in lowering serum glucose, cholesterol and triacylglycerol levels in the ginger-treated diabetic rats compared with the control diabetic rats. The ginger treatment also resulted in a significant reduction in urine protein levels. In addition, the ginger-treated diabetic rats sustained their initial weights during the treatment period. Moreover, ginger decreased both water intake and urine output in the STZ-induced diabetic rats. The present results indicate that raw ginger possesses hypoglycaemic, hypocholesterolaemic and hypolipidaemic potential. Additionally, raw ginger is effective in reversing the diabetic proteinuria observed in the diabetic rats. Thus, ginger may be of great value in managing the effects of diabetic complications in human subjects.

Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe

“…This glycation lowering activity can be linked to the presence of various phenolic components in ginger rhizomes. The pungent fractions of ginger, namely gingerols, shogaols, paradols, and volatile constituents like sesquiterpenes and monoterpenes, are mainly attributed to the healthenhancing perspectives of ginger (Al-Amin et al, 2006;Ojewole, 2006;Islam, Choi, 2008;Butt, Sultan, 2011). The NEG inhibitory activity of ginger depends, at least in part, on its ability to trap reactive carbonyl intermediates in NEG/AGE formation, thereby inhibiting the chemical modification of proteins.…”

“…Although several studies have mentioned antidiabetic activity of Zingiber officinale (Grover et al, 2002;Akhani et al, 2005;Kelble, 2005;Al-Amin et al, 2006;Büyükbalci, Sedef, 2008;Islam, Choi, 2008;Abd-Elraheem et al, 2009;Saraswat et al, 2009;Ogbera et al, 2010;Saraswat et al, 2010;Madkor et al, 2011;Ramudu et al, 2011;Rani et al, 2011), no data is available on protein glycation and glucose absorption inhibitory potential of native Zingiber officinale rhizomes at national level. The present study was undertaken to investigate the antidiabetic effects of Zingiber officinale in terms of glucose diffusion and glycation inhibition.…”

Evaluation of Growth Performance, Haematological and Serum Biochemical Response of Broiler Chickens to Aqueous Extract of Ginger and Garlic

“…Ginger contains several compounds and enzymes including gingerdiol, gingerol, gingerdione and shogaols (Rivlin, 2001;Zhao et al, 2011). These compounds have been reported to have antimicrobial, antioxidative and pharmacological effects (Al-Amin et al, 2006;Tapsell et al, 2006;Ali et al, 2008). Garlic is best known as a spice and herbal medicine for treatment and prevention of an array of diseases (Adibmoradi et al, 2006).…”

Biological Evaluation of the Weight Reduction Capacity of Selected Herbal Products Available in the Kingdom of Saudi Arabia

“…Cumin and ginger have many proven nutraceutical properties including stomachic, diuretic, carminative, emmanogogic, antispasmodic, antimicrobial and hypoglycaemic properties [26]. Al Amin et al [27] found that raw ginger possessed hypoglycaemic, hypocholesterolaemic and hypolipidaemic potential. Although the differences were not significant for the lipid profile and blood glucose levels, the present study supports this finding.…”