Anti-diabetic and hypoglycemic properties of fibre-enriched cake in alloxan-induced diabetic rats

Erukainure, Ochuko L.; Ebuehi, Osaretin Albert Taiwo; Adeboyejo, Folasade Olabimpe; Okafor, E. N.; Hafizur, Rahman M.; Aliyu, Muhammad; Elemo, Gloria N.

doi:10.1007/s12349-012-0116-9

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Therefore, replacing sugar in the current study is a potential goal for T2DM patients in addition to increasing fiber content. In their study, Erukainure et al [12], Ahmed et al [45], and dos Santos et al [46] incorporated BPP and CLP in cakes as a replacement for wheat flour. This was performed to enhance the fiber content, while still maintaining sucrose as the primary sweetener, which accounted for 20-30% of the recipe.…”

Section: Chemical Analysis Of Cupcake Samplesmentioning

confidence: 99%

“…This effect is mainly due to the ability of banana peels to restore the function of pancreatic tissues by increasing insulin output or inhibiting glucose absorption [11]. Furthermore, cakes enriched with banana fibers have demonstrated a therapeutic protective effect against diabetes [12] and can improve the quality and nutritional properties of butter cake by increasing fiber content [13].…”

Section: Introductionmentioning

confidence: 99%

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The Valorization of Agro-Wastes and Stevia Leaves as a Sugar Replacer in Cupcake Formulas: Histological and In Vivo Studies on Diabetic Rats

et al. 2023

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One potential solution to enhance the nutritional value of food while addressing environmental concerns is to use bioactive extracts from agro-waste in the food industry. This study aimed to investigate the effects of replacing sucrose with powders made from Stevia leaves (SLP), banana peels (BPP), and carrot leaves (CLP), as well as their mixtures, in cupcakes. Additionally, the study aimed to determine the impact of these substitutes on alloxan-induced diabetic rats fed the cupcakes. Sensory evaluation revealed that up to 60% of sucrose in the cupcake formula could be replaced without significant changes in sensory attributes. Substituting agro-wastes and SLP increased the protein content from 12.86% to 14.26% and the dietary fiber content from 3.65% to 5.60% compared to the control sample. The treated diabetic groups, particularly those fed cupcakes containing SLP-CLP mixture, showed increased body weight gain % and feed intake, reducing serum glucose levels from 427.5 to 180.8 mg/dL after 28 days. The mix of CLP-SLP had the highest additive effect, indicating a significant reduction in various biochemical parameters, including ALT, AST, albumin, urea, uric acid, creatinine, total cholesterol, triglyceride, and LDL, compared to the positive control. No histopathological alterations were detected in the pancreas and liver of diabetic rats fed cupcakes supplemented with SLP-CLP. However, moderate degenerations were observed in the hepatocytes of diabetic rats fed cupcakes fortified with SLP-BPP.

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Section: Chemical Analysis Of Cupcake Samplesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Valorization of Agro-Wastes and Stevia Leaves as a Sugar Replacer in Cupcake Formulas: Histological and In Vivo Studies on Diabetic Rats

et al. 2023

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“…It could especially inhibit gastrointestinal disease and maintain the health of gastrointestinal tract (47). OL Erukainure et al (47) showed dietary fiber could decrease the fasting blood glucose and sugar tolerance in alloxan-induced diabetic rats. For diabetic patients, the blood sugar level could decrease by consuming approximately 20g dietary fiber daily, making the condition take a favorable improvement.…”

Section: Dietary Fibermentioning

confidence: 99%

Research progress on hypoglycemic active components in natural products

Chen

Liang²,

Hao³

et al. 2016

Eur J Bio Med Res

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Diabetes is one of the most challenging health problems worldwide. Commonly used anti-diabetic drugs include insulin, Pramlintide, GLP-1 receptor agonists and oral hypoglycemic. Due to the limitation of these anti-diabetic drugs related to potency, stability and cell toxicity, new drugs isolated from natural materials have been served for alternative and safe anti-diabetic medications in the most recent decade. In this manuscript, pharmacological reaction and molecular mechanism of hypoglycemic active components in natural products were discussed in detail.

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Optimum biscuit from Musa sapientum L. and Vigna unguiculata L. composite flour: effect on pancreatic histology, biochemical and hematological parameters of diabetic rats

Njapndounke

Saah

Marius

et al. 2021

Heliyon

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This study investigated the effect of consumption of an optimum biscuit from composite flour of Musa sapientum L. (‘ banana cochon’ ) and Vigna unguiculata L. (cowpea) on the pancreatic histology, biochemical and hematological parameters of streptozotocin-induced diabetic Wistar rats. The optimum biscuit was evaluated for its chemical properties and glycaemic index. The weekly fasting blood glucose level, food intake and weight of the rats were recorded. The effect of 28 days' consumption of different percentages of optimum biscuit with/without Metformin was also evaluated on the pancreatic histology, biochemical and hematological parameters of rats. Results showed that, the optimum biscuit is rich in minerals (potassium, magnesium and calcium), dietary fibre (9.4%) and is a low glycaemic index product (50.91%). Also, the optimum biscuit significantly lowered/maintained the blood glucose level of diabetic rats even though the weekly weights of the rats were reduced while food intake increased. Nonetheless, the hematological parameters of the treated diabetic rats were significantly ( P < 0.05) improved when compared to the untreated diabetic rats groups. With the exception of total serum protein, other biochemical parameters such as serum creatinine, urea, alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase and bilirubin in the treated diabetic groups were significantly ( P < 0.05) reduced or closer to those of non-diabetic rats. The serum cholesterol, triglyceride, low-density lipoprotein levels were significantly ( p < 0.05) reduced while the HDL level significantly increased in treated diabetic groups. Histological examination of the pancreas showed that treatment of diabetic groups with optimum biscuit was able to slow down the destruction (protection) of beta-cells. Thus, optimum biscuit could be used to improve the health status during the management and prevention of complications in diabetic patients.

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Anti-diabetic and hypoglycemic properties of fibre-enriched cake in alloxan-induced diabetic rats

Cited by 5 publications

References 23 publications

The Valorization of Agro-Wastes and Stevia Leaves as a Sugar Replacer in Cupcake Formulas: Histological and In Vivo Studies on Diabetic Rats

The Valorization of Agro-Wastes and Stevia Leaves as a Sugar Replacer in Cupcake Formulas: Histological and In Vivo Studies on Diabetic Rats

Research progress on hypoglycemic active components in natural products

Optimum biscuit from Musa sapientum L. and Vigna unguiculata L. composite flour: effect on pancreatic histology, biochemical and hematological parameters of diabetic rats

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