Abstract:Various clinical practices prove that traditional Chinese medicines, integrated traditionalChinese and western medicines make enormous contributions to tumor treatment as well as alleviation of chemotherapy side effect. Alkaloid, polysaccharide and saponin are examples of natural bioactive products that can impede the progression of tumors. Besides, researches on the widely-used tradition Chinese anti-tumor medicine formulas indicate that these agents can induce apoptosis of tumor cells. Therefore, there is an extensive perspective in natural bioactive materials as clinical tumor therapy. This review provides an overview of some natural products used as anti-tumor remedies and the molecular mechanisms they are involved in apoptosis induction, tumor angiogenesis and tumor metastasis.
Diabetes is one of the most challenging health problems worldwide. Commonly used anti-diabetic drugs include insulin, Pramlintide, GLP-1 receptor agonists and oral hypoglycemic. Due to the limitation of these anti-diabetic drugs related to potency, stability and cell toxicity, new drugs isolated from natural materials have been served for alternative and safe anti-diabetic medications in the most recent decade. In this manuscript, pharmacological reaction and molecular mechanism of hypoglycemic active components in natural products were discussed in detail.
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