Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE−/− mice exposed to unpredictable chronic mild stress

Huang, Huai-Syuan; Lin, Yan; Panyod, Suraphan; Chen, Rou-An; Lin, Yingcheng; Chai, Laura Min Xuan; Hsu, Cheng-Chih; Wu, Wei-Kai; Lu, Kuan-Hung; Huang, Yun-Ju; Sheen, Lee‐Yan

doi:10.1016/j.jep.2022.115872

Cited by 12 publications

(6 citation statements)

References 127 publications

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“…A previous study found that, after dietary intervention in mice with cognitive impairment induced by a high-fat diet, the abundance of Defluviitaleaceae UCG-011 increased 89 . After herbal interventions in mice with depression and cognitive decline induced by chronic mild stress, the abundance of Defluviitaleaceae UCG-011 also increased 90 . This implies that Defluviitaleaceae UCG-011 may participate in the protection of cognitive function as a component of the gut-brain axis.…”

Section: Discussionmentioning

confidence: 98%

Gut microbiome and frailty: insight from genetic correlation and mendelian randomization

Cui,

Li,

et al. 2023

Gut Microbes

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Observational studies have shown that the gut microbiome is associated with frailty. However, whether these associations underlie causal effects remains unknown. Thus, this study aimed to assess the genetic correlation and causal relationships between the genetically predicted gut microbiome and frailty using linkage disequilibrium score regression (LDSC) and Mendelian Randomization (MR). Summary statistics for the gut microbiome were obtained from a genome-wide association study (GWAS) meta-analysis of the MiBioGen consortium ( N = 18,340). Summary statistics for frailty were obtained from a GWAS meta-analysis, including the UK Biobank and TwinGene ( N = 175,226). We used LDSC and MR analyses to estimate the genetic correlation and causality between the genetically predicted gut microbiome and frailty. Our findings indicate a suggestive genetic correlation between Christensenellaceae R-7 and frailty. Moreover, we found evidence for suggestive causal effects of twelve genus-level gut microbes on frailty using at least two MR methods. There was no evidence of horizontal pleiotropy or heterogeneity in the MR analysis. This study provides suggestive evidence for a potential genetic correlation and causal association between several genetically predicted gut microbes and frailty. More population-based observational studies and animal experiments are required to clarify this association and the underlying mechanisms.

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Section: Discussionmentioning

confidence: 98%

Gut microbiome and frailty: insight from genetic correlation and mendelian randomization

Cui,

Li,

et al. 2023

Gut Microbes

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“…These effects were documented in Shennong’s Classic of Materia Medica (Shennong Bencaojing), which dates back to approximately 2000 years ago. Modern pharmacology research has shown that the tuber of G. elata has neuroprotective ( Lu et al., 2022 ), anti-inflammatory, antidiabetic ( Yang et al., 2018 ), antioxidative, antiepileptic, anticonvulsive, antipsychotic, anxiolytic, antidepressant ( Gao et al., 2023 ; Huang et al., 2023 ), circulatory system modulating, memory-enhancing ( Chen et al., 2011a ; Chen et al., 2011c ), cardiovascular disease ameliorating ( Chen and Sheen, 2011 ), and other effects. Liu et al.…”

Section: Overview Of G Elata and Its Applicationsmentioning

confidence: 99%

The role of symbiotic fungi in the life cycle of Gastrodia elata Blume (Orchidaceae): a comprehensive review

Liu,

Yang,

et al. 2024

Front. Plant Sci.

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Gastrodia elata Blume, a fully mycoheterotrophic perennial plant of the family Orchidaceae, is a traditional Chinese herb with medicinal and edible value. Interestingly, G. elata requires symbiotic relationships with Mycena and Armillaria strains for seed germination and plant growth, respectively. However, there is no comprehensive summary of the symbiotic mechanism between fungi and G. elata. Here, the colonization and digestion of hyphae, the bidirectional exchange of nutrients, the adaptation of fungi and G. elata to symbiosis, and the role of microorganisms and secondary metabolites in the symbiotic relationship between fungi and G. elata are summarized. We comprehensively and deeply analyzed the mechanism of symbiosis between G. elata and fungi from three perspectives: morphology, nutrition, and molecules. The aim of this review was to enrich the understanding of the mutualistic symbiosis mechanisms between plants and fungi and lay a theoretical foundation for the ecological cultivation of G. elata.

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“…Gastrodin, a bioactive molecule derived from Gastrodia elata , has been used as an injectable for vertigo therapy and has been proved to be safe and effective in many clinical trials ( 188 ). In addition, in vivo studies have shown that Gastrodia elata extract exhibited anti-depressive effects, improved cognitive impairment, and regulated gut microbiome and metabolite regulation ( 111 ). Furthermore, Gastrodia elata extracts have been demonstrated to alleviate Parkinson Disease symptoms by protecting dopaminergic neurons, lowering α-synuclein buildup, and decreasing neuroinflammation, which might be useful in Parkinsonism management ( 189 ).…”

Section: Role Of Medicinal Foods In Managing Post-covid Complicationsmentioning

confidence: 99%

TCM “medicine and food homology” in the management of post-COVID disorders

Ng,

Bun,

Zhao

et al. 2023

Front. Immunol.

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BackgroundThe World Health Organization declared that COVID-19 is no longer a public health emergency of global concern on May 5, 2023. Post-COVID disorders are, however, becoming more common. Hence, there lies a growing need to develop safe and effective treatment measures to manage post-COVID disorders. Investigating the use of TCM medicinal foods in the long-term therapy of post-COVID illnesses may be beneficial given contemporary research’s emphasis on the development of medicinal foods.Scope and approachThe use of medicinal foods for the long-term treatment of post-COVID disorders is highlighted in this review. Following a discussion of the history of the TCM “Medicine and Food Homology” theory, the pathophysiological effects of post-COVID disorders will be briefly reviewed. An analysis of TCM medicinal foods and their functions in treating post-COVID disorders will then be provided before offering some insight into potential directions for future research and application.Key findings and discussionTCM medicinal foods can manage different aspects of post-COVID disorders. The use of medicinal foods in the long-term management of post-COVID illnesses may be a safe and efficient therapy choice because they are typically milder in nature than chronic drug use. These findings may also be applied in the long-term post-disease treatment of similar respiratory disorders.

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Anti-depressive-like and cognitive impairment alleviation effects of Gastrodia elata Blume water extract is related to gut microbiome remodeling in ApoE−/− mice exposed to unpredictable chronic mild stress

Cited by 12 publications

References 127 publications

Gut microbiome and frailty: insight from genetic correlation and mendelian randomization

Gut microbiome and frailty: insight from genetic correlation and mendelian randomization

The role of symbiotic fungi in the life cycle of Gastrodia elata Blume (Orchidaceae): a comprehensive review

TCM “medicine and food homology” in the management of post-COVID disorders

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