Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes

Bhutani, MK; Bishnoi, Mahendra; Kulkarni, Shrinivas K.

doi:10.1016/j.pbb.2008.10.007

Cited by 222 publications

(137 citation statements)

References 41 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…Cur seems to display its antidepressant role by protecting the function of monoaminergic systems and controlling the release of neurotransmitters including dopamine (DA), noradrenaline (NE), and 5-hydroxyindoleacetic acid (5-HIAA). [14][15][16] Nevertheless, the exact mechanism of its antidepressant activity still remains to be explored. Altogether, Cur as a potent approach may show great potential in the management of major depression.…”

Section: Introductionmentioning

confidence: 99%

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Zhu

Wang

et al. 2016

IJN

View full text Add to dashboard Cite

Major depression is a complex neuropsychiatric disorder with few treatment approaches. The use of nontargeted antidepressants induced many side effects with their low efficacy. A more precise targeting strategy is to develop nanotechnology-based drug delivery systems; hence, we employed solid lipid nanoparticles (SLNs) to encapsulate HU-211 and curcumin (Cur). The antidepressant effects of the dual-drug nanoparticles (Cur/SLNs-HU-211) for major depression treatment were investigated in corticosterone-induced cellular and animal models of major depression. Cur/SLNs-HU-211 can effectively protect PC12 cells from corticosterone-induced apoptosis and can release more dopamine, which may be associated with the higher uptake of Cur/SLNs-HU-211 shown by cellular uptake behavior analysis. Additionally, Cur/SLNs-HU-211 significantly reduced the immobility time in forced swim test, enhanced fall latency in rotarod test, and improved the level of dopamine in mice blood. Cur/SLNs-HU-211 can deliver more Cur to the brain and thus produce a significant increase in neurotransmitters level in brain tissue, especially in the hippocampus and striatum. The results of Western blot and immunofluorescence revealed that Cur/SLNs-HU-211 can significantly enhance the expression of CB1, p-MEK1, and p-ERK1/2. Our study suggests that Cur/SLNs-HU-211 may have great potential for major depression treatment.

show abstract

Section: Introductionmentioning

confidence: 99%

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Zhu

Wang

et al. 2016

IJN

View full text Add to dashboard Cite

show abstract

“…More specifically, curcumin is a potent antioxidant that can lower markers of oxidative stress (Naik et al, 2011, Rai et al, 2010, modulate immuno-inflammation by acting as a COX-2 inhibitor (Lee et al, 2011, Plummer et al, 1999 and lower pro-inflammatory cytokines (Basnet andSkalko-Basnet, 2011, Belcaro et al, 2010), provide significant neuroprotection , Xu et al, 2007, modulate HPA activity , Li et al, 2009) and influence monoamine transmission through its effect on serotonergic and dopaminergic activity (Bhutani et al, 2009, Kulkarni et al, 2008, Xia et al, 2007. In animal studies, antidepressant effects of curcumin have been attributed to its serotonergic, dopaminergic, neuroprotective and HPA-modulating effects , Kulkarni et al, 2008, Xu et al, 2006.…”

Section: Introductionmentioning

confidence: 99%

Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study

Lopresti

Maes

Maker

et al. 2014

Journal of Affective Disorders

171

100

View full text Add to dashboard Cite

show abstract

“…CUMS is a well-known effective model to imitate the pathogenesis of depression (Bhutani et al, 2009). In this study, rats in CUMS displayed representative anhedonia behavior, as indicated by their decreased sucrose preference.…”

Section: Discussionmentioning

confidence: 73%

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Gao

et al. 2017

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological relevance: There are many plants of genus Piper which have been reported to induce antidepressant-like effects, Piper sarmentosum (PS) is one of them. PS is a Chinese herbal medicine and a traditional edible vegetable. Materials and Methods:In the present study, the antidepressant-like effects of PS extracts and the ethyl acetate fraction of PS extracts (PSY) were assessed using the open field test (OFT), forced swimming test (FST), and tail suspension test (TST) in mice. Furthermore, we applied a 4 consecutive weeks of chronic unpredictable mild stress (CUMS) as a model of depression in rats, followed by a sucrose preference test. Then we examined the possible mechanisms of this action.The activity of the hypothalamic-pituitary-adrenal (HPA) axis was evaluated by detecting the serum corticosterone (CORT) concentrations, and the protein expression levels of brain-derived neurotrophic factor (BDNF), the phosphorylated form CREB and ERK1/2 were detected by qRT-PCR or Western blot. Results:The results showed that PS extracts (100, 200 mg/kg) and PSY (12.5, 25, 50 mg/kg) treatment produced antidepressant-like effects in mice similar to fluoxetine (20 mg/kg), indicated by the reduced immobility time in the FST and TST, while both had no influence on the locomotor activity in the OFT. PSY treatment significantly increased sucrose preference and reduced serum CORT levels in CUMS rats. Moreover, PSY up-regulated BDNF protein levels, and increased CREB and ERK phosphorylation levels in the hippocampus on CUMS rats. Conclusions:These findings suggest that the antidepressant-like effects of PS extracts and PSY are mediated, at least in part, by modulating HPA axis, BDNF, CREB and ERK phosphorylation and expression in the hippocampus.

show abstract

Anti-depressant like effect of curcumin and its combination with piperine in unpredictable chronic stress-induced behavioral, biochemical and neurochemical changes

Cited by 222 publications

References 41 publications

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Antidepressant effects of curcumin and HU-211 coencapsulated solid lipid nanoparticles against corticosterone-induced cellular and animal models of major depression

Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study

Piper sarmentosum Roxb. produces antidepressant-like effects in rodents, associated with activation of the CREB-BDNF-ERK signaling pathway and reversal of HPA axis hyperactivity

Contact Info

Product

Resources

About