Anti-cytomegalovirus preemptive therapy to prevent cytomegalovirus disease in HIV-infected patients: a systematic review

Sattwika, Prenali Dwisthi; Subronto, Yanri Wijayanti; Retnowulan, Heni; Sattwika, Karina Ambar; Nurdiati, Detty Siti

doi:10.1080/23744235.2023.2165708

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…In contrast to our findings, a recent systematic review 16 did not find a reduction in the incidence of CMV EOD (RR = 0.84, 95 % CI 0.59‒1.18), but did found a reduction in the Relative Risk (RR) of all-cause mortality rate (RR = 0.85, 95 % CI 0.74‒0.97). This discrepancies in the results may have been due to differences in the types of participants included in each review.…”

Section: Discussioncontrasting

confidence: 99%

Efficacy and safety of preemptive therapy for cytomegalovirus end-organ disease in people living with HIV: a systematic review and meta-analysis

Díaz-Brochero,

Nocua-Báez,

Valderrama-Rios

et al. 2023

The Brazilian Journal of Infectious Diseases

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Section: Discussioncontrasting

confidence: 99%

Efficacy and safety of preemptive therapy for cytomegalovirus end-organ disease in people living with HIV: a systematic review and meta-analysis

Díaz-Brochero,

Nocua-Báez,

Valderrama-Rios

et al. 2023

The Brazilian Journal of Infectious Diseases

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Clinical, epidemiological, and drug resistance insights into HIV-positive patients in Meizhou, China

Liu,

Patil,

Guo

et al. 2024

Front. Cell. Infect. Microbiol.

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The acquired immunodeficiency syndrome (AIDS) epidemic, resulting from human immunodeficiency virus (HIV) infection, exhibits distinct regional characteristics. This study undertakes a retrospective analysis of the epidemiological and clinical features of 195 HIV-positive cases in Meizhou, China, from May 1, 2018 to December 31, 2019. Western blotting (WB) confirmed and assessed these cases. Notably, the majority of cases emanated from socio-economic groups with comparatively lower levels of education, with 80% being male. Strikingly, 90% of the cases were found to be in the middle to late stages of infection based on CD4+ T cell counts. Among the 30 different serum antibody profiles examined, reactivity with seven bands (p24, p31, gp41, p51, p66, gp120, and gp160) emerged as the most commonly observed WB pattern. The absence of specific bands, specifically p55 (17.44%), p39 (32.31%), and p17 (25.64%) were most frequent, with the detection frequency of p17 bands significantly reduced among cases in the AIDS and middle stages. An analysis of drug resistance genotypes indicated that, despite viral mutations conferring resistance to certain reverse transcriptase inhibitors, the first-line treatment regimen remained effective for patients in Meizhou. Notably, mutations resistant to protease inhibitors were infrequent (2.7%), suggesting that incorporating protease inhibitors into the treatment regimen may enhance therapeutic outcomes for local patients. These findings provide essential insights into the specific epidemiological patterns, serum antibody profiles, and drug resistance genotypes of HIV-infected patients in Meizhou. Significantly, this research contributes to the formulation of future treatment strategies tailored to the local context.

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Anti-cytomegalovirus preemptive therapy to prevent cytomegalovirus disease in HIV-infected patients: a systematic review

Cited by 2 publications

References 26 publications

Efficacy and safety of preemptive therapy for cytomegalovirus end-organ disease in people living with HIV: a systematic review and meta-analysis

Efficacy and safety of preemptive therapy for cytomegalovirus end-organ disease in people living with HIV: a systematic review and meta-analysis

Clinical, epidemiological, and drug resistance insights into HIV-positive patients in Meizhou, China

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